Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology

Pro-Resolving FPR2 Agonists Regulate NADPH Oxidase-Dependent Phosphorylation of HSP27, OSR1, and MARCKS and Activation of the Respective Upstream Kinases

(2021) Rosario Ammendola et al.   Antioxidants

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential

(2021) Monika Maciuszek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

(2020) Juliette Giacobbe et al.   Frontiers in Psychiatry

Phosphorylation Sites in Protein Kinases and Phosphatases Regulated by Formyl Peptide Receptor 2 Signaling

(2020) Maria Carmela Annunziata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

(2020) Yoshikazu Asahina et al.   JOURNAL OF MEDICINAL CHEMISTRY

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain

(2020) Shaomin Li et al.   JOURNAL OF NEUROCHEMISTRY

The Predicted Key Molecules, Functions, and Pathways That Bridge Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

(2020) Ye Tao et al.   Frontiers in Neurology

G-protein coupled receptors involved in the resolution of inflammation: ligands and therapeutic perspectives.

(2020) Margherita Mastromarino et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology

(2020) Mauro Perretti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation

(2020) Antonio Recchiuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury

(2020) Guang-Jie Liu et al.   Journal of Neuroinflammation

Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors

(2019) Stacey A Krepel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Eicosanoids in Alzheimer’s Disease

(2019) Roger G. Biringer   International Journal of Environmental Research and Public Health

Resolvin D1 as a novel anti-inflammatory marker in manic, depressive and euthymic states of bipolar disorder

(2019) Burcu Kok Kendirlioglu et al.   NORDIC JOURNAL OF PSYCHIATRY

Phosphoproteomic analysis sheds light on intracellular signaling cascades triggered by Formyl-Peptide Receptor 2

(2019) Fabio Cattaneo et al.   Scientific Reports

Expression of heat shock protein 70 and Annexin A1 in serum of patients with acutely severe traumatic brain injury

(2019) Junjing Zhao et al.   Experimental and Therapeutic Medicine

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

Biased perspectives on formyl peptide receptors

(2018) Carsten Alexander Raabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel ureidopropanamide based N -formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation

(2017) Madia Letizia Stama et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

(2017) Hui-Qiong He et al.   MOLECULES

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells

(2017) Jinyan Xu et al.   MEDICAL SCIENCE MONITOR

Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery

(2017) Kimberly E. Hawkins et al.   Brain and Behavior

Identification of two phosphorylation sites essential for annexin A1 in blood–brain barrier protection after experimental intracerebral hemorrhage in rats

(2016) Zhong Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson's disease rat model

(2015) Yuguang Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1–PDZ-domain

(2015) Ozge Sensoy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

(2015) Jordan L. Harrison et al.   BRAIN BEHAVIOR AND IMMUNITY

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders

(2015) Kunio Yui et al.   Current Neuropharmacology

New development in studies of formyl-peptide receptors: critical roles in host defense

(2015) L. Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peptide length and folding state govern the capacity of staphylococcal β-type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2

(2015) Dorothee Kretschmer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adaptive Evolution of Formyl Peptide Receptors in Mammals

(2015) Yoshinori Muto et al.   JOURNAL OF MOLECULAR EVOLUTION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Structural Studies of G Protein-Coupled Receptors

(2015)   MOLECULES AND CELLS

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

(2015) Sarah E. Headland et al.   Science Translational Medicine

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development of Small Molecule Non-peptide Formyl Peptide Receptor (FPR) Ligands and Molecular Modeling of Their Recognition

(2014) I.A. Schepetkin et al.   CURRENT MEDICINAL CHEMISTRY

Protective Effects of BML-111 on Cerulein-Induced Acute Pancreatitis-Associated Lung Injury via Activation of Nrf2/ARE Signaling Pathway

(2014) Ying-zhen Wang et al.   INFLAMMATION

Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors

(2014) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Formyl Peptides from Listeria monocytogenes and Staphylococcus aureus as Potent Chemoattractants for Mouse Neutrophils

(2014) E. L. Southgate et al.   JOURNAL OF IMMUNOLOGY

Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease A  Synaptotoxicity

(2014) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice

(2014) Caroline P. Klein et al.   NEUROPHARMACOLOGY

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders

(2014) Irene Gallo et al.   PLoS One

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis

(2014) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis

(2014) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands

(2013) Joel W. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4

(2013) Julien Hanson et al.   BIOCHEMICAL PHARMACOLOGY

Defining and characterizing drug/compound function

(2013) Terry Kenakin et al.   BIOCHEMICAL PHARMACOLOGY

Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline

(2013) Niccolò Terrando et al.   FASEB JOURNAL

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution

(2013) J. G. Filep   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BML-111, a Lipoxin Receptor Agonist, Attenuates Ventilator-Induced Lung Injury in Rats

(2013) Hongbin Li et al.   SHOCK

Annexin A1 Interaction with the FPR2/ALX Receptor

(2012) Stefania Bena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats

(2012) Jie Gong et al.   RESUSCITATION

Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

(2011) Min He et al.   ACTA PHARMACOLOGICA SINICA

Lipoxin A4 is a novel estrogen receptor modulator

(2011) Ronan Russell et al.   FASEB JOURNAL

N-Formyl Peptide Receptor 3 (FPR3) Departs from the Homologous FPR2/ALX Receptor with Regard to the Major Processes Governing Chemoattractant Receptor Regulation, Expression at the Cell Surface, and Phosphorylation

(2011) Marie-Josèphe Rabiet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Lipoxin A 4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion

(2010) Xi-Hong Ye et al.   BRAIN RESEARCH

Lipoxin A4 attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects

(2010) FP Conte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

(2010) P Prieto et al.   CELL DEATH AND DIFFERENTIATION

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells

(2010) Lars-Ove Brandenburg et al.   JOURNAL OF NEUROCHEMISTRY

Expression and Signaling of Formyl-Peptide Receptors in the Brain

(2010) Fabio Cattaneo et al.   NEUROCHEMICAL RESEARCH

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

(2010) Neil Dufton et al.   PHARMACOLOGY & THERAPEUTICS

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization in GPCR mobility and signaling

(2009) Martin J Lohse   CURRENT OPINION IN PHARMACOLOGY

Formyl Peptide Receptor-Like 2 Is Expressed and Functional in Plasmacytoid Dendritic Cells, Tissue-Specific Macrophage Subpopulations, and Eosinophils

(2009) T. Devosse et al.   JOURNAL OF IMMUNOLOGY

Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

(2009) Stéphane Rivière et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ

(2009) S. D. Liberles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formyl-peptide receptor like 1: A potent mediator of the Ca2+ release-activated Ca2+ current ICRAC

(2008) Yong-Sheng Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

(2008) M. Dona et al.   BLOOD