Nanotechnologies for intranasal drug delivery: an update of literature

Role of Omega-3 Fatty Acids and Butter Oil in Targeting Delivery of Donepezil Hydrochloride Microemulsion to Brain via the Intranasal Route: a Comparative Study

(2020) Dignesh Khunt et al.   AAPS PHARMSCITECH

Natural and Synthetic Polymers Assisted Development of Lurasidone Hydrochloride Intranasal Mucoadhesive Microspheres

(2020) Shoaib Khan et al.   Indian Journal of Pharmaceutical Education and Research

Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax

(2020) Chad W. Stratilo et al.   PLoS One

Induction of systemic immunity through nasal-associated lymphoid tissue (NALT) of mice intranasally immunized with Brucella abortus malate dehydrogenase-loaded chitosan nanoparticles

(2020) Soojin Shim et al.   PLoS One

Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

(2020) Qiang Zhao et al.   Frontiers in Pharmacology

Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery

(2020) Yue Sun et al.   International Journal of Nanomedicine

Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose-to-Brain Delivery of a Hydrophilic Drug Molecule

(2020) Lamis H. Salem et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes

(2020) Harkiranpreet Kaur Dhaliwal et al.   MOLECULAR PHARMACEUTICS

Design and development of a commercially potential in situ nanoemulgel for the treatment of postmenopausal osteoporosis

(2020) Foziyah Zakir et al.   Nanomedicine

Nasal Mucoadhesive Microspheres of Lercanidipine with Improved Systemic Bioavailability and Antihypertensive Activity

(2020) Sarwar Beg et al.   Journal of Pharmaceutical Innovation

Current Status at Drug Delivery Approaches and Assay of Anti-Migraine Drugs

(2020) Ozgur Esim et al.   Current Drug Delivery

Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus

(2020) Lili Zhao et al.   Nanomaterials

Treatment of Alzheimer’s diseases using donepezil nanoemulsion: an intranasal approach

(2020) Atinderpal Kaur et al.   Drug Delivery and Translational Research

Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies

(2020) Aakash Katdare et al.   Drug Delivery and Translational Research

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning

(2020) Lara Diego-González et al.   Pharmaceutics

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity

(2020) Yaping Mai et al.   CELLULAR IMMUNOLOGY

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

(2020) Roxana Popescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intranasal delivery of topiramate nanoemulsion: Pharmacodynamic, pharmacokinetic and brain uptake studies

(2020) Ravish J. Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intranasal delivery of icariin via a nanogel-thermoresponsive hydrogel compound system to improve its antidepressant-like activity

(2020) Dong Xu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preparation, characterization, and optimization of asenapine maleate mucoadhesive nanoemulsion using Box-Behnken design: In vitro and in vivo studies for brain targeting

(2020) Santosh Ashok Kumbhar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhancement in brain uptake of vitamin D3 nanoemulsion for treatment of cerebral ischemia: formulation, gamma scintigraphy and efficacy study in transient middle cerebral artery occlusion rat models

(2020) Mukesh Kumar et al.   JOURNAL OF MICROENCAPSULATION

In vitro investigations on dopamine loaded Solid Lipid Nanoparticles

(2020) Stefania Cometa et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Antimicrobial Essential Oil Formulation: Chitosan Coated Nanoemulsions for Nose to Brain Delivery

(2020) Federica Rinaldi et al.   Pharmaceutics

Brain uptake and accumulation of new levofloxacin-doxycycline combination through the use of solid lipid nanoparticles: Formulation; Optimization and in-vivo evaluation

(2020) Mayssa Abdel Hady et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies

(2019) Dnyandev G. Gadhave et al.   AAPS PHARMSCITECH

In silico search, chemical characterization and immunogenic evaluation of amino-terminated G4-PAMAM-HIV peptide complexes using three-dimensional models of the HIV-1 gp120 protein

(2019) Rolando Alberto Rodríguez-Fonseca et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Spray-dried nanoparticle-loaded pectin microspheres for dexamethasone nasal delivery

(2019) Bisera Jurišić Dukovski et al.   DRYING TECHNOLOGY

Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation

(2019) Nozad Hussein et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design

(2019) Gifty M. Jojo et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies

(2019) Dnyandev G. Gadhave et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Optimization of nanostructured lipid carriers of Lurasidone hydrochloride using Box-Behnken design for brain targeting: in vitro & in vivo studies

(2019) Imrana Jazuli Annu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effective encapsulation of apomorphine into biodegradable polymeric nanoparticles through a reversible chemical bond for delivery across the blood–brain barrier

(2019) Jeremy Pang Kern Tan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoencapsulated retinoic acid as a safe tolerogenic adjuvant for intranasal vaccination against cutaneous leishmaniasis

(2019) Izabella P.S. Bezerra et al.   VACCINE

Chlorpheniramine maleate containing chitosan-based nanoparticle-loaded thermosensitive in situ gel for management in allergic rhinitis

(2019) Manish Kumar et al.   Drug Delivery and Translational Research

Recent expansions of novel strategies towards the drug targeting into the brain

(2019) Amit Alexander et al.   International Journal of Nanomedicine

Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

(2019) Bappaditya Chatterjee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Microneedle coating methods: a review with a perspective

(2019) Rohan Ingrole et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive in situ nasal gelling systems

(2019) Preeti Pandey et al.   SAUDI PHARMACEUTICAL JOURNAL

Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus

(2019) Armira Azuar et al.   ACS Medicinal Chemistry Letters

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

(2019) Sitah Al Harthi et al.   Scientific Reports

A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study

(2019) Yifan Chen et al.   AAPS PHARMSCITECH

Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles

(2019) Liping Wang et al.   Nanomedicine

Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide

(2019) Uday K. Sukumar et al.   BIOMATERIALS

Development of nose-to-brain delivery of ketoconazole by nanostructured lipid carriers against cryptococcal meningoencephalitis in mice

(2019) Wei Du et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation

(2019) Marina G. Dogbe et al.   Pharmaceutics

Pharmacokinetics, pharmacodynamics and toxicity of Baicalin liposome on cerebral ischemia reperfusion injury rats via intranasal administration

(2019) Yan Xiang et al.   BRAIN RESEARCH

Development, characterisation and nasal deposition of melatonin-loaded pectin/hypromellose microspheres

(2019) Laura Nižić et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus

(2019) Somayeh Taymouri et al.   IET Nanobiotechnology

Intranasal delivery of cancer-targeting doxorubicin-loaded PLGA nanoparticles arrests glioblastoma growth

(2019) Kunho Chung et al.   JOURNAL OF DRUG TARGETING

Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation

(2019) Mahmoud M Omar et al.   Drug Design Development and Therapy

Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia

(2019) Niyaz Ahmad et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System

(2018) Carlos Galeano et al.   CELL TRANSPLANTATION

In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

(2018) Alessandro Giuliani et al.   DRUG DELIVERY

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

(2018) Qingqing Meng et al.   International Journal of Nanomedicine

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

(2018) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Nose-to-brain delivery of insulin enhanced by a nanogel carrier

(2018) Pasquale Picone et al.   JOURNAL OF CONTROLLED RELEASE

Mechanism of intranasal drug delivery directly to the brain

(2018) Tyler P. Crowe et al.   LIFE SCIENCES

Formulation and In-vivo Pharmacokinetic Consideration of Intranasal Microemulsion and Mucoadhesive Microemulsion of Rivastigmine for Brain Targeting

(2018) Brijesh Shah et al.   PHARMACEUTICAL RESEARCH

Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice

(2018) Xiaofeng Lai et al.   Scientific Reports

Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development

(2018) C. Tonda-Turo et al.   Biomed Research International

Enhancement of drug permeability across blood brain barrier using nanoparticles in meningitis

(2018) Keerthi G. S. Nair et al.   INFLAMMOPHARMACOLOGY

Brain targeting of chitosan-based diazepam mucoadhesive micro emulsions via nasal route: Formulation optimization, characterization, Pharmacokinetic and Pharmacodynamic evaluations

(2018) Srividya Ramreddy et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Chemical cross-linking: A feasible approach to prolong doxylamine/pyridoxine release from spray-dried chitosan microspheres

(2018) Plamen Katsarov et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

in vitro- and in vivo Evaluation of Methotrexate-Loaded Hydrogel Nanoparticles Intended to Treat Primary CNS Lymphoma via Intranasal Administration

(2018) Leila Pourtalebi Jahromi et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

(2018) Stella Gänger et al.   Pharmaceutics

Evaluation of intranasal delivery route of drug administration for brain targeting

(2018) Franciska Erdő et al.   BRAIN RESEARCH BULLETIN

Pharmacology of new and developing intravenous therapies for the management of seizures and epilepsy

(2018) Alessandra Morano et al.   EXPERT OPINION ON PHARMACOTHERAPY

Quantum dot induced acute changes in lung mechanics are mouse strain dependent

(2018) David K. Scoville et al.   INHALATION TOXICOLOGY

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

(2018) Giovanna Rassu et al.   Pharmaceutics

Lamotrigine encapsulated intra-nasal nanoliposome formulation for epilepsy treatment: Formulation design, characterization and nasal toxicity study

(2018) Arshiya Praveen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanoformulations for dimethyl fumarate: Physicochemical characterization and in vitro / in vivo behavior

(2017) Elisabetta Esposito et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nasal Anatomy and Function

(2017) Ruchin Patel   FACIAL PLASTIC SURGERY

Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular

(2017) Armaghan Emami et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Progress in brain targeting drug delivery system by nasal route

(2017) Abdur Rauf Khan et al.   JOURNAL OF CONTROLLED RELEASE

Modélisation in vitro de la barrière hémato-encéphalique

(2017) Fabien Gosselet   M S-MEDECINE SCIENCES

Quality by Design approach for an in situ gelling microemulsion of Lorazepam via intranasal route

(2017) Vidhi Shah et al.   Materials Science & Engineering C-Materials for Biological Applications

Nanogel-based nasal ghrelin vaccine prevents obesity

(2017) T Azegami et al.   Mucosal Immunology

Revisiting the role of sucrose in PLGA-PEG nanocarrier for potential intranasal delivery

(2017) A. Bonaccorso et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Intranasal drug delivery devices and interventions associated with post-operative endoscopic sinus surgery

(2017) Lari K. Dkhar et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Thiolated Chitosan Masked Polymeric Microspheres with Incorporated Mesocellular Silica Foam (MCF) for Intranasal Delivery of Paliperidone

(2017) Stavroula Nanaki et al.   Polymers

Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection

(2016) Hui-Wen Chen et al.   BIOMATERIALS

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs

(2016) Paula Oliveira et al.   CURRENT DRUG METABOLISM

The efficacy and safety of sumatriptan intranasal powder in adults with acute migraine

(2016) Frederick G. Freitag et al.   Expert Review of Neurotherapeutics

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

(2016) Adryana Clementino et al.   International Journal of Nanomedicine

Nasal immunization with mannan-decorated mucoadhesive HPMCP microspheres containing ApxIIA toxin induces protective immunity against challenge infection with Actinobacillus pleuropneumoiae in mice

(2016) Hui-Shan Li et al.   JOURNAL OF CONTROLLED RELEASE

Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications

(2016) Mindaugas Rudokas et al.   MEDICAL PRINCIPLES AND PRACTICE

The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy

(2016) Mei-Xia Zhao et al.   Nanoscale Research Letters

Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial

(2016) Daniel S. Quintana et al.   PSYCHONEUROENDOCRINOLOGY

The efficacy and safety of sumatriptan intranasal powder in adults with acute migraine

(2016) Frederick G. Freitag et al.   Expert Review of Neurotherapeutics

Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida infection

(2016) Crystal N. Propst et al.   JOURNAL OF NANOBIOTECHNOLOGY

The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy

(2016) Mei-Xia Zhao et al.   Nanoscale Research Letters

Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses

(2016) Benjamin Schwarz et al.   ACS Biomaterials-Science & Engineering

Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses

(2016) Benjamin Schwarz et al.   ACS Biomaterials Science & Engineering

Intranasal Drug Delivery: How, Why and What for?

(2016) Anaísa Pires et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Nanotechnology in Drug Delivery: Safety and Toxicity Issues

(2015) Keerti Jain et al.   CURRENT PHARMACEUTICAL DESIGN

Mannan-decorated thiolated Eudragit microspheres for targeting antigen presenting cells via nasal vaccination

(2015) Hui-Shan Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Application of quality by design approach for intranasal delivery of rivastigmine loaded solid lipid nanoparticles: Effect on formulation and characterization parameters

(2015) Brijesh Shah et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Brain Targeting of a Water Insoluble Antipsychotic Drug Haloperidol via the Intranasal Route Using PAMAM Dendrimer

(2015) Yogesh K. Katare et al.   MOLECULAR PHARMACEUTICS

Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

(2015) Y Fukuyama et al.   Mucosal Immunology

Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment

(2015) D S Quintana et al.   Translational Psychiatry

Development and evaluation of carboplatin-loaded PCL nanoparticles for intranasal delivery

(2014) Angel Treasa Alex et al.   DRUG DELIVERY

Current approaches to enhance CNS delivery of drugs across the brain barriers

(2014) Cui-Tao Lu et al.   International Journal of Nanomedicine

Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation

(2014) Mohd Yasir et al.   Acta Pharmaceutica Sinica B

Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation

(2013) Lifeng Gao et al.   JOURNAL OF APPLIED TOXICOLOGY

Nose-to-brain transport of aerosolised quantum dots following acute exposure

(2013) Laurie E. Hopkins et al.   Nanotoxicology

Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits

(2012) Yanjun Zhao et al.   AAPS Journal

Current oral and non-oral routes of antiepileptic drug delivery

(2012) Gail D. Anderson et al.   ADVANCED DRUG DELIVERY REVIEWS

Preparation and in vitro characterization of mucoadhesive hydroxypropyl guar microspheres containing amlodipine besylate for nasal administration

(2012) N. G. N. Swamy et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Thermo-sensitive gels containing lorazepam microspheres for intranasal brain targeting

(2012) S. Jose et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanostructured lipid carriers system: Recent advances in drug delivery

(2012) Md Asif Iqbal et al.   JOURNAL OF DRUG TARGETING

Intranasal delivery of insulin via the olfactory nerve pathway

(2012) Dan B. Renner et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Anatomical and Histological Factors Affecting Intranasal Drug and Vaccine Delivery

(2012) Sveinbjorn Gizurarson   Current Drug Delivery

SLN approach for nose-to-brain delivery of alprazolam

(2012) Alok Pratap Singh et al.   Drug Delivery and Translational Research

The human olfactory mucosa

(2009) Pedro Alberto Escada et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nasal Delivery of High Molecular Weight Drugs

(2009) Yıldız Ozsoy et al.   MOLECULES

Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging

(2008) Catherine J. Murphy et al.   ACCOUNTS OF CHEMICAL RESEARCH