Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model

Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis

(2020) Lan Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model

(2020) Ke-xin Wang et al.   Frontiers in Pharmacology

A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus

(2020) Yao Gao et al.   Frontiers in Pharmacology

A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective

(2020) Ke-Xin Wang et al.   Frontiers in Pharmacology

Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis

(2019) Tianshuang Xia et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

(2019) Zhang-qi Cao et al.   Frontiers in Pharmacology

Luteolin improves heart preservation through inhibiting hypoxia‑dependent L‑type calcium channels in cardiomyocytes

(2019) Qingfeng Yan et al.   Experimental and Therapeutic Medicine

Efficacy and safety of Zuogui Pill in treating osteoporosis

(2019) Guoming Chen et al.   MEDICINE

Lactoferrin ameliorates aging-suppressed osteogenesis via IGF1 signaling

(2019) Xinwei Chen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Formation via Reducing the Liver Oxalate Biosynthesis and Renal Oxidative Stress-Mediated Cell Injury

(2019) Wei Zhu et al.   Oxidative Medicine and Cellular Longevity

Angelica polysaccharide promotes proliferation and osteoblast differentiation of mesenchymal stem cells by regulation of long non-coding RNA H19

(2019) Xiaoyan Xie et al.   Bone & Joint Research

Integrated pathological cell fishing and network pharmacology approach to investigate main active components of Er-Xian decotion for treating osteoporosis

(2019) Nani Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway

(2019) Nani Wang et al.   Frontiers in Pharmacology

ESR1 Gene Variants Are Predictive of Osteoporosis in Female Patients with Crohn’s Disease

(2019) Iwona Krela-Kaźmierczak et al.   Journal of Clinical Medicine

Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis

(2019) Wenjuan Zhang et al.   LIFE SCIENCES

Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women

(2019) Alina Deniza Ciubean et al.   PLoS One

The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

(2019) Sok Kuan Wong et al.   Drug Design Development and Therapy

Zuogui Pill improves the dexamethasone-induced osteoporosis progression in zebrafish larvae

(2018) Heng Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Altered MicroRNA Profile in Osteoporosis Caused by Impaired WNT Signaling

(2018) Riikka E Mäkitie et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation

(2018) Tamilselvam Rajavel et al.   Scientific Reports

Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis

(2018) Liang Zhang et al.   Scientific Reports

Calycosin Orchestrates Osteogenesis of Danggui Buxue Tang in Cultured Osteoblasts: Evaluating the Mechanism of Action by Omics and Chemical Knock-out Methodologies

(2018) Amy G. W. Gong et al.   Frontiers in Pharmacology

The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

(2018) Vladimira Mondockova et al.   BMC Medical Genetics

Investigation of inulins from the roots of Morinda officinalis for potential therapeutic application as anti-osteoporosis agent

(2018) Keming Jiang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs

(2018) Michael D. Shultz   JOURNAL OF MEDICINAL CHEMISTRY

Liuwei Dihuang pill cures postmenopausal osteoporosis with kidney-Yin deficiency

(2018) Feng Xu et al.   MEDICINE

System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia

(2018) Chun Wang et al.   Frontiers in Pharmacology

Bone Protective Effects of Danggui Buxue Tang Alone and in Combination With Tamoxifen or Raloxifene in vivo and in vitro

(2018) Li-Ping Zhou et al.   Frontiers in Pharmacology

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand

(2018) Julia Luther et al.   Science Translational Medicine

The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women

(2017) Marian Majchrzycki et al.   Ginekologia Polska

Bajijiasu Abrogates Osteoclast Differentiation via the Suppression of RANKL Signaling Pathways through NF-κB and NFAT

(2017) Guoju Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of collagen type I alpha 1 +1245G/T polymorphism and osteoporosis risk in post-menopausal women: a meta-analysis

(2017) Jian Wu et al.   International Journal of Rheumatic Diseases

VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption

(2017) Yuko Nakamichi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathview Web: user friendly pathway visualization and data integration

(2017) Weijun Luo et al.   NUCLEIC ACIDS RESEARCH

Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells

(2017) Guangming Zhao et al.   ONCOLOGY REPORTS

TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus

(2017) Hongjun Zhao et al.   RHEUMATOLOGY

Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

(2017) Jin-Yu Li et al.   Clinical Interventions in Aging

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Liuwei Dihuang Pill (六味地黄丸) Treats Postmenopausal Osteoporosis with Shen (Kidney) Yin Deficiency via Janus Kinase/Signal Transducer and Activator of Transcription Signal Pathway by Up-regulating Cardiotrophin-Like Cytokine Factor 1 Expression

(2016) Ji-rong Ge et al.   Chinese Journal of Integrative Medicine

A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

(2016) Huiping Liu et al.   Evidence-based Complementary and Alternative Medicine

Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice

(2016) Zhiguo Zhang et al.   FITOTERAPIA

Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women

(2016) D.P. Shang et al.   GENETICS AND MOLECULAR RESEARCH

An insertion/deletion polymorphism within the 3′-untranslated region of COL1A2 confers susceptibility to osteoporosis

(2016) Zhen-Song Jiang et al.   Molecular Medicine Reports

Postmenopausal Osteoporosis

(2016) Dennis M. Black et al.   NEW ENGLAND JOURNAL OF MEDICINE

Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-like receptors 2 and 4

(2015) C. P. C. Marques et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

(2015) Lili Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Polymorphisms of collagen 1A1 (COL1A1) gene and their relation to bone mineral density in postmenopausal women

(2015) Marian Majchrzycki et al.   Ginekologia Polska

Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

(2015) S. Zhao et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro

(2015) Sandhiya Sriraman et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Er-Xian Decoction Exerts Estrogen-Like Osteoprotective Effects In Vivo and In Vitro

(2014) Ka-Chun Wong et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data

(2014) Daogang Guan et al.   BIOINFORMATICS

Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice

(2014) Tadashi Goto et al.   CYTOTECHNOLOGY

High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio

(2014) Zhiguo Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology

(2014) Yingli Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women

(2014) Lianmei Luo et al.   MOLECULAR BIOLOGY REPORTS

PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data

(2014) Daogang Guan et al.   NUCLEIC ACIDS RESEARCH

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

(2014) David Gfeller et al.   NUCLEIC ACIDS RESEARCH

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Common Polymorphism in theLRP5Gene May Increase the Risk of Bone Fracture and Osteoporosis

(2014) Guang-Yue Xu et al.   Biomed Research International

HitPick: a web server for hit identification and target prediction of chemical screenings

(2013) X. Liu et al.   BIOINFORMATICS

Impact of genetic variants of IL-6, IL6R, LRP5, ESR1 and SP7 genes on bone mineral density in postmenopausal Mexican-Mestizo women with obesity

(2013) Juan Pablo Méndez et al.   GENE

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

(2013) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

(2013) Christine M. Laine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells

(2013) Song Hyo Sook et al.   PHYTOTHERAPY RESEARCH

Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women

(2012) Sengul Tural et al.   GENE

Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats

(2012) Qing-Feng Xie et al.   JOURNAL OF ETHNOPHARMACOLOGY

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils

(2012) Rafael Liz et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis

(2012) Ruichao Xue et al.   NUCLEIC ACIDS RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

SHBG levels are associated with bone loss and vertebral fractures in patients with prostate cancer

(2012) M. Varsavsky et al.   OSTEOPOROSIS INTERNATIONAL

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of CaV1.1 calcium channel

(2011) Zhen Zhi Tang et al.   HUMAN MOLECULAR GENETICS

TNFRSF11B gene polymorphisms 1181G>C and 245T>G as well as haplotype CT influence bone mineral density in postmenopausal women

(2011) Simona Mencej-Bedrač et al.   MATURITAS

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Menopause-associated Symptoms and Cognitive Performance: Results From the Study of Women's Health Across the Nation

(2010) G. A. Greendale et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss

(2010) Tae-Ho Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin

(2010) Chien-Chung Chen et al.   LIFE SCIENCES

The Pharmacological Effects of Morroniside and Loganin Isolated from Liuweidihuang Wan, on MC3T3-E1 Cells

(2010) Manyu Li et al.   MOLECULES

β-Sitosterol Inhibits Cell Growth and Induces Apoptosis in SGC-7901 Human Stomach Cancer Cells

(2009) Yonghuan Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts

(2009) Yan-Bin Wu et al.   MOLECULES

Fracture, bone mineral density, and the effects of calcitonin receptor gene in postmenopausal Koreans

(2009) H.-J. Lee et al.   OSTEOPOROSIS INTERNATIONAL

Antiosteoporotic activity of phenolic compounds from Curculigo orchioides

(2009) Lei Jiao et al.   PHYTOMEDICINE

β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis

(2008) Cheol PARK et al.   ACTA PHARMACOLOGICA SINICA

The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density

(2008) Nicola Napoli et al.   BONE

Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula

(2008) Luping Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology