β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation

Beta sitosterol and Daucosterol (phytosterols identified in Grewia tiliaefolia) perturbs cell cycle and induces apoptotic cell death in A549 cells

(2017) Tamilselvam Rajavel et al.   Scientific Reports

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

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Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

(2015) Hala Gali-Muhtasib et al.   APOPTOSIS

Role of Phytosterols in Cancer Prevention and Treatment

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Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer

(2015) Muhammad Shahdaat Bin Sayeed et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

Assessment of dual inhibition property of newly discovered inhibitors against PCAF and GCN5 throughin silicoscreening, molecular dynamics simulation and DFT approach

(2014) Venkatesan Suryanarayanan et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Insights into the structural basis of 3,5-diaminoindazoles as CDK2 inhibitors: prediction of binding modes and potency by QM–MM interaction, MESP and MD simulation

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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

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Physics-based enzyme design: Predicting binding affinity and catalytic activity

(2014) Sarah Sirin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

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(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modulation of signal transduction in cancer cells by phytosterols

(2010) Peter G. Bradford et al.   BIOFACTORS

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

(2010) Albert A Baskar et al.   BMC Complementary and Alternative Medicine

Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis

(2010) Zuojun Guo et al.   Chemical Biology & Drug Design

Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation

(2010) Therese Christina Karlenius et al.   Cancers

Anticancer effects of phytosterols

(2009) T A Woyengo et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

β-Sitosterol Inhibits Cell Growth and Induces Apoptosis in SGC-7901 Human Stomach Cancer Cells

(2009) Yonghuan Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity

(2008) R. Paniagua-Pérez et al.   ARCHIVES OF TOXICOLOGY

β-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways

(2008) Dong-Oh Moon et al.   CANCER LETTERS

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER

Caspases in apoptosis and beyond

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Plant-derived compounds in clinical trials

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