β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways

(2018) Yifei Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Simultaneous determination of fourteen compounds of Hedyotis diffusa Willd extract in rats by UHPLC-MS / MS method: Application to pharmacokinetics and tissue distribution study

(2018) Xiaoqing Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling

(2018) Qingcai Meng et al.   ONCOGENE

Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent

(2018) Yi-pu Fan et al.   Frontiers in Pharmacology

KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer

(2018) Yeo Wool Kang et al.   CANCER LETTERS

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

(2018) Naiara Santana-Codina et al.   Nature Communications

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

(2017) Daniela Massihnia et al.   Journal of Hematology & Oncology

A systematic review of the prognostic value of lymph node ratio, number of positive nodes and total nodes examined in pancreatic ductal adenocarcinoma

(2017) M Elshaer et al.   ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53

(2016) Hany A. Omar et al.   Frontiers in Pharmacology

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

(2015) Hala Gali-Muhtasib et al.   APOPTOSIS

CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling

(2015) Shao-Lai Zhou et al.   CANCER LETTERS

PI3K/Akt signaling in osteosarcoma

(2015) Jian Zhang et al.   CLINICA CHIMICA ACTA

Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer

(2015) Muhammad Shahdaat Bin Sayeed et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

(2015) LIN YE et al.   Oncology Letters

AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial–mesenchymal transition of prostate cancer cells

(2014) Zong-cai Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

(2014) F. M. Millimouno et al.   Cancer Prevention Research

Posttranslational regulation of Akt in human cancer

(2014) Chia-Hsin Chan et al.   Cell and Bioscience

Adjuvant therapy for resectable pancreatic adenocarcinoma: Review of the current treatment approaches and future directions

(2013) G. Antoniou et al.   CANCER TREATMENT REVIEWS

Nir1 promotes invasion of breast cancer cells by binding to chemokine (C–C motif) ligand 18 through the PI3K/Akt/GSK3β/Snail signalling pathway

(2013) Baogang Zhang et al.   EUROPEAN JOURNAL OF CANCER

Succinate Dehydrogenase 5 (SDH5) Regulates Glycogen Synthase Kinase 3β-β-Catenin-mediated Lung Cancer Metastasis

(2013) Jun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation

(2011) Xiaohua Zhang et al.   CANCER SCIENCE

The epithelial-mesenchymal transition (EMT) phenomenon

(2010) P. Savagner   ANNALS OF ONCOLOGY

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

(2010) Albert A Baskar et al.   BMC Complementary and Alternative Medicine

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

The Flavonoid Apigenin Potentiates the Growth Inhibitory Effects of Gemcitabine and Abrogates Gemcitabine Resistance in Human Pancreatic Cancer Cells

(2009) Matthew J. Strouch et al.   PANCREAS

β-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways

(2008) Dong-Oh Moon et al.   CANCER LETTERS

The determinants of traditional Chinese medicine and acupuncture utilization for cancer patients with simultaneous conventional treatment

(2008) C.-Y. PU et al.   EUROPEAN JOURNAL OF CANCER CARE

Novel advances in pancreatic cancer treatment

(2008) Michel Vulfovich et al.   Expert Review of Anticancer Therapy

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

(2007) Sang Hyub Lee et al.   CANCER LETTERS