Natural and synthetic peptides with antifungal activity

A hemocyanin-derived antimicrobial peptide from the penaeid shrimp adopts an alpha-helical structure that specifically permeabilizes fungal membranes

(2016) Vanessa W. Petit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms

(2016) Haining Yu et al.   BIOCHIMIE

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Interaction of antifungal peptide BP15 with Stemphylium vesicarium , the causal agent of brown spot of pear

(2016) Mireia Puig et al.   Fungal Biology

Characterization and expression of the antifungal protein from Monascus pilosus and its distribution among various Monascus species

(2016) Ching-Yu Tu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Cloning and purification of the first termicin-like peptide from the cockroach Eupolyphaga sinensis

(2016) Zichao Liu et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

An overview of antifungal peptides derived from insect

(2016) Mohammad Omer Faruck et al.   PEPTIDES

The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

(2016) Kim Vriens et al.   PEPTIDES

Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties

(2015) Kaiyang Lim et al.   Acta Biomaterialia

Development andIn VivoEvaluation of a Novel Histatin-5 Bioadhesive Hydrogel Formulation against Oral Candidiasis

(2015) Eric F. Kong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Concatemerization increases the inhibitory activity of short, cell-penetrating, cationic and tryptophan-rich antifungal peptides

(2015) Belén López-García et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial peptides: an alternative for innovative medicines?

(2015) João Pinto da Costa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial peptide protonectin disturbs the membrane integrity and induces ROS production in yeast cells

(2015) Kairong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide

(2015) L.A.C. Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A novel antifungal peptide from leaves of the weed Stellaria media L

(2015) Eugene A. Rogozhin et al.   BIOCHIMIE

BaAMPs: the database of biofilm-active antimicrobial peptides

(2015) Mariagrazia Di Luca et al.   BIOFOULING

Synthetic β-sheet forming peptide amphiphiles for treatment of fungal keratitis

(2015) Hong Wu et al.   BIOMATERIALS

Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides

(2015) Chandradhish Ghosh et al.   ChemMedChem

Naturally Occurring Peptides from Rana temporaria: Antimicrobial Properties and More

(2015) Maria Luisa Mangoni et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers

(2015) Paulina Zielińska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae)

(2015) Carlos López-Abarrategui et al.   FASEB JOURNAL

Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii

(2015) Camilla Eggert Larsen et al.   FEMS YEAST RESEARCH

Antagonistic Activities of Novel Peptides from Bacillus amyloliquefaciens PT14 against Fusarium solani and Fusarium oxysporum

(2015) Young Gwon Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antifungal therapy: drug–drug interactions at your fingertips

(2015) Vincent J. Lempers et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthesis, Structural Characterization, and Bioactivity of the Stable Peptide RCB-1 from Ricinus communis

(2015) Delgerbat Boldbaatar et al.   JOURNAL OF NATURAL PRODUCTS

Synthetic antimicrobialβ-peptide in dual-treatment with fluconazole or ketoconazole enhances thein vitroinhibition of planktonic and biofilmCandida  albicans

(2015) Camilo Mora-Navarro et al.   JOURNAL OF PEPTIDE SCIENCE

Antifungal effect and action mechanism of antimicrobial peptide polybia-CP

(2015) Kairong Wang et al.   JOURNAL OF PEPTIDE SCIENCE

Engineering of a linear inactive analog of human β-defensin 4 to generate peptides with potent antimicrobial activity

(2015) Himanshu Sharma et al.   JOURNAL OF PEPTIDE SCIENCE

Antifungal Compounds from Cyanobacteria

(2015) Tânia Shishido et al.   Marine Drugs

Marine Peptides and Their Anti-Infective Activities

(2015) Hee Kang et al.   Marine Drugs

Structure based virtual screening to discover putative drug candidates: Necessary considerations and successful case studies

(2015) Mohd Danishuddin et al.   METHODS

The role of thionins in rice defence against root pathogens

(2015) Hongli Ji et al.   MOLECULAR PLANT PATHOLOGY

Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents

(2015) Lisa Lombardi et al.   MOLECULES

Antifungal nanofibers made by controlled release of sea animal derived peptide

(2015) Juliane F. C. Viana et al.   Nanoscale

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Antifungal activity of cathelicidin peptides against planktonic and biofilm cultures of Candida species isolated from vaginal infections

(2015) Michele Scarsini et al.   PEPTIDES

Novel proline-hydroxyproline glycopeptides from the dandelion (Taraxacum officinale Wigg.) flowers: de novo sequencing and biological activity

(2015) Alexandra A. Astafieva et al.   PLANT SCIENCE

QuBiLs-MAS method in early drug discovery and rational drug identification of antifungal agents

(2015) R. Medina Marrero et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis

(2015) Soraya Z. Ferreira et al.   ACS Medicinal Chemistry Letters

Activity of Novel Synthetic Peptides against Candida albicans

(2015) Kah Yean Lum et al.   Scientific Reports

The antifungal plant defensin AhPDF1.1b is a beneficial factor involved in adaptive response to zinc overload when it is expressed in yeast cells

(2015) Oriane Mith et al.   MicrobiologyOpen

Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection

(2015) Namrata Raman et al.   ACS Biomaterials-Science & Engineering

Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection

(2015) Namrata Raman et al.   ACS Biomaterials Science & Engineering

Peptide-based antifungal therapies against emerging infections

(2015) A. Matejuk et al.   DRUGS OF THE FUTURE

Identification of a Novel Proline-Rich Antimicrobial Peptide from Brassica napus

(2015) Huihui Cao et al.   PLoS One

Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures

(2015) Kim Vriens et al.   PLoS One

Plant-Derived Decapeptide OSIP108 Interferes with Candida albicans Biofilm Formation without Affecting Cell Viability

(2014) N. Delattin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plant Antimicrobial Peptides Snakin-1 and Snakin-2: Chemical Synthesis and Insights into the Disulfide Connectivity

(2014) Paul W. R. Harris et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antimicrobial Peptides: Promising Compounds Against Pathogenic Microorganisms

(2014) J. Cruz et al.   CURRENT MEDICINAL CHEMISTRY

Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin

(2014) C. Yin et al.   CURRENT MOLECULAR MEDICINE

How Does It Kill?: Understanding the Candidacidal Mechanism of Salivary Histatin 5

(2014) Sumant Puri et al.   EUKARYOTIC CELL

Interplay between Candida albicans and the Antimicrobial Peptide Armory

(2014) Marc Swidergall et al.   EUKARYOTIC CELL

Antimicrobial peptides: therapeutic potentials

(2014) Su-Jin Kang et al.   Expert Review of Anti-Infective Therapy

Novel Formulations for Antimicrobial Peptides

(2014) Ana Carmona-Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Balticidins A–D, Antifungal Hassallidin-Like Lipopeptides from the Baltic Sea Cyanobacterium Anabaena cylindrica Bio33

(2014) Thanh-Huong Bui et al.   JOURNAL OF NATURAL PRODUCTS

Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei

(2014) Diaa Youssef et al.   Marine Drugs

Antifungal Plant Defensins: Mechanisms of Action and Production

(2014) Kim Vriens et al.   MOLECULES

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of microbial biofilms in the post-antibiotic era: prophylactic and therapeutic use of antimicrobial peptides and their design by bioinformatics tools

(2014) Mariagrazia Di Luca et al.   Pathogens and Disease

Histatin 5-Spermidine Conjugates Have Enhanced Fungicidal Activity and Efficacy as a Topical Therapeutic for Oral Candidiasis

(2013) Swetha Tati et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Boosting Salt Resistance of Short Antimicrobial Peptides

(2013) Hung-Lun Chu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid

(2013) Gaetano Del Gaudio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans

(2013) Brigitte M. E. Hayes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial and Antibiofilm Activity of Designed and Synthesized Antimicrobial Peptide, KABT-AMP

(2013) Bency Thankappan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Antifungal effect of CopA3 monomer peptide via membrane-active mechanism and stability to proteolysis of enantiomeric d-CopA3

(2013) Hyemin Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and antimicrobial activity of cysteine-free coprisin nonapeptides

(2013) Jaeho Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antifungal effect and pore-forming action of lactoferricin B like peptide derived from centipede Scolopendra subspinipes mutilans

(2013) Hyemin Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanism of action of novel synthetic dodecapeptides against Candida albicans

(2013) Indresh Kumar Maurya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

P-113 Peptide: New experimental evidences on its biological activity and conformational insights from molecular dynamics simulations

(2013) Alessia Di Giampaolo et al.   BIOPOLYMERS

C. albicans growth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W

(2013) Simon Theberge et al.   BMC MICROBIOLOGY

Properties and mechanisms of action of naturally occurring antifungal peptides

(2013) Nicole L. van der Weerden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of Candida albicans oral infection

(2013) S. H. Shin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates ofCandida albicans

(2013) Indresh Kumar Maurya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)—A case study

(2013) James M. Balkovec et al.   NATURAL PRODUCT REPORTS

Novel antifungal α-hairpinin peptide from Stellaria media seeds: structure, biosynthesis, gene structure and evolution

(2013) Anna A. Slavokhotova et al.   PLANT MOLECULAR BIOLOGY

In vivo application of a small molecular weight antifungal protein of Penicillium chrysogenum (PAF)

(2013) Zoltán Palicz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Peptide array based discovery of synthetic antimicrobial peptides

(2013) Chris W. Diehnelt   Frontiers in Microbiology

Apoptosis-inducing antifungal peptides and proteins: Table 1

(2012) Katrijn De Brucker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans

(2012) Stefania Conti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Unraveling the antifungal activity of a South American rattlesnake toxin crotamine

(2012) Erica S. Yamane et al.   BIOCHIMIE

A Peptide Derived from the Highly Conserved Protein GAPDH Is Involved in Tissue Protection by Different Antifungal Strategies and Epithelial Immunomodulation

(2012) Jeanette Wagener et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Isolation, Structure, and Biological Activity of Phaeofungin, a Cyclic Lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test

(2012) Sheo B. Singh et al.   JOURNAL OF NATURAL PRODUCTS

Burkholdines from Burkholderia ambifaria: Antifungal Agents and Possible Virulence Factors

(2012) Zhenjian Lin et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5

(2012) Elżbieta Kamysz et al.   JOURNAL OF PEPTIDE SCIENCE

Antifungal properties of durancins isolated fromEnterococcus duransA5-11 and of its synthetic fragments

(2012) Y. Belguesmia et al.   LETTERS IN APPLIED MICROBIOLOGY

Advances in the Synthesis of Bioactive Unnatural Amino Acids and Peptides

(2012) R. Saladino et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26

(2012) Alberto Muñoz et al.   MOLECULAR MICROBIOLOGY

Experimental Methodologies and Evaluations of Computer-Aided Drug Design Methodologies Applied to a Series of 2-Aminothiophene Derivatives with Antifungal Activities

(2012) Luciana Scotti et al.   MOLECULES

Antimicrobial Peptides for Therapeutic Applications: A Review

(2012) Min-Duk Seo et al.   MOLECULES

Peptides of the Constant Region of Antibodies Display Fungicidal Activity

(2012) Luciano Polonelli et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Commercialization of antifungal peptides

(2012) Vanessa M.S. Duncan et al.   Fungal Biology Reviews

Antifungal proteins: More than antimicrobials?

(2012) Nikoletta Hegedüs et al.   Fungal Biology Reviews

Analyzing the Cryptome: Uncovering Secret Sequences

(2011) Parimal Samir et al.   AAPS Journal

Ultrashort Peptide Bioconjugates Are Exclusively Antifungal Agents and Synergize with Cyclodextrin and Amphotericin B

(2011) Christopher J. Arnusch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endocytosis-Mediated Vacuolar Accumulation of the Human ApoE Apolipoprotein-Derived ApoEdpL-W Antimicrobial Peptide Contributes to Its Antifungal Activity in Candida albicans

(2011) Tristan Rossignol et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide derived from anti-idiotypic single-chain antibody is a potent antifungal agent compared to its parent fungicide HM-1 killer toxin peptide

(2011) M. Enamul Kabir et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Induction of yeast apoptosis by an antimicrobial peptide, Papiliocin

(2011) Bomi Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the lipodepsipeptide syringomycin E in phospholipids and sodium dodecylsulphate micelle studied by circular dichroism, NMR spectroscopy and molecular dynamics

(2011) Massimiliano Anselmi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The antimicrobial peptide arenicin-1 promotes generation of reactive oxygen species and induction of apoptosis

(2011) Jaeyong Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Killer peptide: a novel paradigm of antimicrobial, antiviral and immunomodulatory auto-delivering drugs

(2011) Walter Magliani et al.   Future Medicinal Chemistry

Disulfide-stabilized Helical Hairpin Structure and Activity of a Novel Antifungal Peptide EcAMP1 from Seeds of Barnyard Grass (Echinochloa crus-galli)

(2011) Svetlana B. Nolde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survival Strategies of Yeast and Filamentous Fungi against the Antifungal Protein AFP

(2011) Jean Paul Ouedraogo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation

(2011) Santi M. Mandal et al.   PEPTIDES

Properties of the bubble protein, a defensin and an abundant component of a fungal exudate

(2011) Marcus Seibold et al.   PEPTIDES

The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis

(2010) Huaying Wang et al.   BIOMATERIALS

Design, synthesis and antimicrobial properties of non-hemolytic cationic α-cyclopeptoids

(2010) Daniela Comegna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Curvularides A-E: Antifungal Hybrid Peptide-Polyketides from the Endophytic Fungus Curvularia geniculata

(2010) Porntep Chomcheon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches

(2010) Riadh Hammami et al.   DRUG DISCOVERY TODAY

Lipopeptide induces apoptosis in fungal cells by a mitochondria-dependent pathway

(2010) Gaofu Qi et al.   PEPTIDES

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Increased potency of a novel d-β-naphthylalanine-substituted antimicrobial peptide against  fluconazole-resistant  fungal pathogens

(2009) Chih-Wei Wang et al.   FEMS YEAST RESEARCH

Abhisin: A potential antimicrobial peptide derived from histone H2A of disk abalone (Haliotis discus discus)

(2009) Mahanama De Zoysa et al.   FISH & SHELLFISH IMMUNOLOGY

Loss of mannosylphosphate from Candida albicans cell wall proteins results in enhanced resistance to the inhibitory effect of a cationic antimicrobial peptide via reduced peptide binding to the cell surface

(2009) Mark Harris et al.   MICROBIOLOGY-SGM

Structure–activity relations of parasin I, a histone H2A-derived antimicrobial peptide

(2008) Young Sook Koo et al.   PEPTIDES

Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities

(2008) Luciano Polonelli et al.   PLoS One

Bacillus lipopeptides: versatile weapons for plant disease biocontrol

(2008) Marc Ongena et al.   TRENDS IN MICROBIOLOGY

Structural and functional characterization of the porcine proline–rich antifungal peptide SP-B isolated from salivary gland granules

(2007) T. Cabras et al.   JOURNAL OF PEPTIDE SCIENCE

Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CSαβ defensins

(2007) Shunyi Zhu   MOLECULAR IMMUNOLOGY