Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates ofCandida albicans
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Title
Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates ofCandida albicans
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 23, Pages 16775-16787
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2013-04-17
DOI
10.1074/jbc.m113.467159
References
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Note: Only part of the references are listed.- Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance
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- A key structural domain of theCandida albicansMdr1 protein
- (2012) Ajeet Mandal et al. BIOCHEMICAL JOURNAL
- Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a d-octapeptide derivative inhibitor
- (2012) Kyoko Niimi et al. MOLECULAR MICROBIOLOGY
- Homodimerization of Amyloid Precursor Protein at the Plasma Membrane: A homoFRET Study by Time-Resolved Fluorescence Anisotropy Imaging
- (2012) Viviane Devauges et al. PLoS One
- Rationale-Based,De NovoDesign of Dehydrophenylalanine-Containing Antibiotic Peptides and Systematic Modification in Sequence for Enhanced Potency
- (2011) Sarika Pathak et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Quorum-Sensing Molecule Farnesol Is a Modulator of Drug Efflux Mediated by ABC Multidrug Transporters and Synergizes with Drugs in Candida albicans
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- Transmembrane helix dimerization: Beyond the search for sequence motifs
- (2011) Edwin Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Comparative Lipidomics of Azole Sensitive and Resistant Clinical Isolates of Candida albicans Reveals Unexpected Diversity in Molecular Lipid Imprints
- (2011) Ashutosh Singh et al. PLoS One
- Mechanism of the Synergistic Effect of Amiodarone and Fluconazole in Candida albicans
- (2010) S. Gamarra et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p
- (2009) Irena Ivnitski-Steele et al. ANALYTICAL BIOCHEMISTRY
- Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals
- (2009) M. Sharma et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antimicrobial Action of Prototypic Amphipathic Cationic Decapeptides and Their Branched Dimers
- (2009) Pooja C. Dewan et al. BIOCHEMISTRY
- The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport
- (2009) Nidhi Puri et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Efflux-Mediated Antifungal Drug Resistance
- (2009) R. D. Cannon et al. CLINICAL MICROBIOLOGY REVIEWS
- PRALINETM: a strategy for improved multiple alignment of transmembrane proteins
- (2008) W. Pirovano et al. BIOINFORMATICS
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