One size does not fit all: Challenging some dogmas and taboos in drug discovery

Hide and seek: Identification and confirmation of small molecule protein targets

(2015) Andrei Ursu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Learning from PAINful lessons

(2015) Daniel A. Erlanson   JOURNAL OF MEDICINAL CHEMISTRY

Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

(2015) Shane M. Devine et al.   JOURNAL OF MEDICINAL CHEMISTRY

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

(2015) Jayme L. Dahlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

2014 FDA drug approvals

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular targets of aspirin and cancer prevention

(2014) L Alfonso et al.   BRITISH JOURNAL OF CANCER

Should the Incorporation of Structural Alerts be Restricted in Drug Design? An Analysis of Structure-Toxicity Trends with Aniline-Based Drugs

(2014) A.S. Kalgutkar   CURRENT MEDICINAL CHEMISTRY

Polypharmacology: the rise of multitarget drugs over combination therapies

(2014) Michela Rosini   Future Medicinal Chemistry

Potential strategies for increasing drug-discovery productivity

(2014) John G Cumming et al.   Future Medicinal Chemistry

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Phenotypic screening in the 21st century

(2014) Birgit T. Priest et al.   Frontiers in Pharmacology

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

Compound promiscuity: what can we learn from current data?

(2013) Ye Hu et al.   DRUG DISCOVERY TODAY

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Polypharmacology – Foe or Friend?

(2013) Jens-Uwe Peters   JOURNAL OF MEDICINAL CHEMISTRY

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Four Lessons from Global Health Drug Discovery: Medicine for an Ailing Industry?

(2012) Richard L. Elliott   ACS Medicinal Chemistry Letters

Polypharmacology: drug discovery for the future

(2012) A Srinivas Reddy et al.   Expert Review of Clinical Pharmacology

Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity

(2011) Catarina Charneira et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

(2011) Romualdo Benigni et al.   CHEMICAL REVIEWS

Managing the Liabilities Arising from Structural Alerts: A Safe Philosophy for Medicinal Chemists

(2011) P. J. Edwards et al.   CURRENT MEDICINAL CHEMISTRY

Drug discovery in the next decade: innovation needed ASAP

(2011) Youssef L. Bennani   DRUG DISCOVERY TODAY

Growing PAINS in academic drug discovery

(2011) Adrian Whitty   Future Medicinal Chemistry

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

False Positives in the Early Stages of Drug Discovery

(2010) R. Sink et al.   CURRENT MEDICINAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Productivity Shortfalls in Drug Discovery: Contributions from the Preclinical Sciences?

(2010) M. Williams   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?

(2008) Amit S Kalgutkar et al.   Expert Review of Clinical Pharmacology

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY