Polypharmacology: the rise of multitarget drugs over combination therapies

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

Polypharmacology – Foe or Friend?

(2013) Jens-Uwe Peters   JOURNAL OF MEDICINAL CHEMISTRY

How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment

(2012) Ye Hu et al.   AAPS Journal

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

The role of fragment-based and computational methods in polypharmacology

(2011) Giovanni Bottegoni et al.   DRUG DISCOVERY TODAY

Networking for new drugs

(2011) Claire Ainsworth   NATURE MEDICINE

Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy

(2010) Carlo Melchiorre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Selectively Nonselective Kinase Inhibition: Striking the Right Balance

(2009) Richard Morphy   JOURNAL OF MEDICINAL CHEMISTRY

Predicting promiscuity

(2009) Andrew L. Hopkins   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs

(2008) Mark J. Millan   Neurotherapeutics