Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors

Conformational spread and dynamics in allostery of NMDA receptors

(2020) Ryan J. Durham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

(2020) Jesse E. Hanson et al.   Cell Reports

Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

(2020) Kelvin Chan et al.   Nature Communications

Structural Basis of Functional Transitions in Mammalian NMDA Receptors

(2020) Tsung-Han Chou et al.   CELL

Architecture and function of NMDA receptors: an evolutionary perspective

(2020) David Stroebel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

(2020) Rebecca F. Krall et al.   Science Advances

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity

(2020) Johansen B. Amin et al.   NEURON

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

(2019) Josep Dalmau et al.   LANCET NEUROLOGY

Towards resolving the presynaptic NMDA receptor debate

(2018) Guy Bouvier et al.   CURRENT OPINION IN NEUROBIOLOGY

Mechanism of NMDA receptor channel block by MK-801 and memantine

(2018) Xianqiang Song et al.   NATURE

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

(2018) Kiran Sapkota et al.   BIOCHEMICAL PHARMACOLOGY

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

(2018) Farzad Jalali-Yazdi et al.   CELL

An inter‐dimer allosteric switch controls NMDA receptor activity

(2018) Jean‐Baptiste Esmenjaud et al.   EMBO JOURNAL

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

(2018) Jin-Bao Zhang et al.   Cell Reports

Unconventional NMDA Receptor Signaling

(2017) Kim Dore et al.   JOURNAL OF NEUROSCIENCE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

NMDA receptors: linking physiological output to biophysical operation

(2017) Gary J. Iacobucci et al.   NATURE REVIEWS NEUROSCIENCE

Structure and symmetry inform gating principles of ionotropic glutamate receptors

(2017) Shujia Zhu et al.   NEUROPHARMACOLOGY

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

(2017) Wei Lü et al.   SCIENCE

A pipeline approach to single-particle processing inRELION

(2017) Rafael Fernandez-Leiro et al.   Acta Crystallographica Section D-Structural Biology

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors

(2016) Feng Yi et al.   NEURON

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

(2016) David H. Hackos et al.   NEURON

Allosteric modulators of NMDA receptors: multiple sites and mechanisms

(2015) Shujia Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

A structural biology perspective on NMDA receptor pharmacology and function

(2015) Michael C Regan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glycine-dependent activation of NMDA receptors

(2015) Kirstie A. Cummings et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gene Expression Switching of Receptor Subunits in Human Brain Development

(2015) Ossnat Bar-Shira et al.   PLoS Computational Biology

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Structural Insights into Competitive Antagonism in NMDA Receptors

(2014) Annie Jespersen et al.   NEURON

Zinc Dynamics and Action at Excitatory Synapses

(2014) Angela Maria Vergnano et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

GRIN2A mutations cause epilepsy-aphasia spectrum disorders

(2013) Gemma L Carvill et al.   NATURE GENETICS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain

(2013) Shujia Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

C-terminal Domains ofN-Methyl-d-aspartic Acid Receptor Modulate Unitary Channel Conductance and Gating

(2012) Bruce A. Maki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

(2012) S. Edman et al.   NEUROPHARMACOLOGY

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors

(2012) Morgane Riou et al.   PLoS One

NMDA Receptor Hypofunction, Parvalbumin-Positive Neurons, and Cortical Gamma Oscillations in Schizophrenia

(2012) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

(2010) I. Talukder et al.   JOURNAL OF NEUROSCIENCE

A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors

(2010) B. M. Costa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia

(2009) T. B. Halene et al.   GENES BRAIN AND BEHAVIOR

Memantine binding to a superficial site on NMDA receptors contributes to partial trapping

(2009) Shawn E. Kotermanski et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum

(2008) Matthew T. Whittaker et al.   JOURNAL OF NEUROCHEMISTRY

Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives

(2008) Oleg I. Barygin et al.   NEUROSCIENCE LETTERS