Hypertension meets osteoarthritis — revisiting the vascular aetiology hypothesis
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Title
Hypertension meets osteoarthritis — revisiting the vascular aetiology hypothesis
Authors
Keywords
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Journal
Nature Reviews Rheumatology
Volume 17, Issue 9, Pages 533-549
Publisher
Springer Science and Business Media LLC
Online
2021-07-27
DOI
10.1038/s41584-021-00650-x
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Note: Only part of the references are listed.- Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies
- (2021) Kenneth Lo et al. Journal of Orthopaedic Translation
- Association of blood pressure with knee cartilage composition and structural knee abnormalities: data from the osteoarthritis initiative
- (2020) Walid Ashmeik et al. SKELETAL RADIOLOGY
- Wnt Pathway Gene Expression Is Associated With Arterial Stiffness
- (2020) Allison L. Kuipers et al. Journal of the American Heart Association
- Metabolic syndrome, hypertension, and hyperglycemia were positively associated with knee osteoarthritis, while dyslipidemia showed no association with knee osteoarthritis
- (2020) Yinhao Xie et al. CLINICAL RHEUMATOLOGY
- Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
- (2020) Darja Andreev et al. JOURNAL OF CLINICAL INVESTIGATION
- Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis
- (2020) Keita Nagira et al. Scientific Reports
- Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development
- (2020) Weiping Su et al. JCI Insight
- The M-CSF receptor in osteoclasts and beyond
- (2020) Se Hwan Mun et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank
- (2020) Zahra Raisi‐Estabragh et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Endothelin-1 induces chondrocyte senescence and cartilage damage via endothelin receptor type B in a post-traumatic osteoarthritis mouse model
- (2020) M. Au et al. OSTEOARTHRITIS AND CARTILAGE
- HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro
- (2019) Jie Zhu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Causal factors for knee, hip and hand osteoarthritis: a Mendelian randomization study in the UK Biobank
- (2019) Thomas Funck‐Brentano et al. Arthritis & Rheumatology
- Vascular pathology and osteoarthritis: A systematic review
- (2019) Sultana Monira Hussain et al. JOURNAL OF RHEUMATOLOGY
- Wnt signaling: a promising target for osteoarthritis therapy
- (2019) Yudan Wang et al. Cell Communication and Signaling
- Lack of evidence that beta blocker use reduces knee pain, areas of joint pain, or analgesic use among individuals with symptomatic knee osteoarthritis
- (2019) L. Zhou et al. OSTEOARTHRITIS AND CARTILAGE
- WNT Signaling in Disease
- (2019) Ng et al. Cells
- Differential Expression of Renin-Angiotensin System-related Components in Patients with Rheumatoid Arthritis and Osteoarthritis
- (2019) Yuangang Wu et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Impairment of bone microstructure and upregulation of osteoclastogenic markers in spontaneously hypertensive rats
- (2019) Wacharaporn Tiyasatkulkovit et al. Scientific Reports
- The Antihypertensive Drug Nifedipine Modulates the Metabolism of Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells
- (2019) Ilona Uzieliene et al. Frontiers in Endocrinology
- Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial CellsHighlights
- (2018) Maaike Schillemans et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis
- (2018) Dzenita Muratovic et al. BONE
- Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice
- (2018) Jiansen Lu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Role of systemic hypertension in cell senescence and subchondral bone disturbance of knee joint
- (2018) P. Chan et al. OSTEOARTHRITIS AND CARTILAGE
- A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
- (2018) V. Deshmukh et al. OSTEOARTHRITIS AND CARTILAGE
- Subchondral bone circulation in osteoarthritis of the human knee
- (2018) R.K. Aaron et al. OSTEOARTHRITIS AND CARTILAGE
- Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis
- (2018) Zhongyu Liu et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Interplay between the renin-angiotensin system, the canonical WNT/β-catenin pathway and PPARγ in hypertension
- (2018) Alexandre Vallée et al. CURRENT HYPERTENSION REPORTS
- Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women
- (2018) MT Sanchez-Santos et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Factors affecting intraosseous pressure measurement
- (2018) Michael Beverly et al. Journal of Orthopaedic Surgery and Research
- Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
- (2018) Shouan Zhu et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypertension and cardiac arrhythmias
- (2017) Gregory Y H Lip et al. EUROPEAN HEART JOURNAL
- Is subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?
- (2017) Pok Man Boris Chan et al. MEDICAL HYPOTHESES
- Association between hypertension and risk of knee osteoarthritis
- (2017) Yi-min Zhang et al. MEDICINE
- Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system
- (2017) Kaizhong Yan et al. Molecular Medicine Reports
- Cell–matrix signals specify bone endothelial cells during developmental osteogenesis
- (2017) Urs H. Langen et al. NATURE CELL BIOLOGY
- The role of metabolism in the pathogenesis of osteoarthritis
- (2017) Ali Mobasheri et al. Nature Reviews Rheumatology
- The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study
- (2017) T. Kendzerska et al. OSTEOARTHRITIS AND CARTILAGE
- Knee osteoarthritis has doubled in prevalence since the mid-20th century
- (2017) Ian J. Wallace et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Do immune cells lead the way in subchondral bone disturbance in osteoarthritis?
- (2017) Adrian Weber et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Association of Beta-Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis
- (2017) Ana M. Valdes et al. ARTHRITIS CARE & RESEARCH
- Biology of Bone: The Vasculature of the Skeletal System
- (2017) Emma C. Watson et al. Cold Spring Harbor Perspectives in Medicine
- Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study
- (2017) Jingbo Niu et al. Arthritis & Rheumatology
- Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats
- (2016) G Youcef et al. BRITISH JOURNAL OF PHARMACOLOGY
- Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation
- (2016) Chao Liu et al. Integrative Biology
- Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain
- (2016) John L Hamilton et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes
- (2016) Wing Yee Cheung et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair
- (2016) Kai Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- Endothelin-1 concentrations are correlated with the severity of knee osteoarthritis
- (2016) Zhe Zhao et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study
- (2016) A. M. Elsaman et al. JOURNAL OF RHEUMATOLOGY
- Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk
- (2016) Steven R. Goldring et al. Nature Reviews Rheumatology
- Role of endothelin-1 in endochondral ossification and osteoarthritis
- (2016) W. Zhao et al. OSTEOARTHRITIS AND CARTILAGE
- Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis
- (2016) M. Shabestari et al. OSTEOARTHRITIS AND CARTILAGE
- Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation
- (2016) A. Bertuglia et al. OSTEOARTHRITIS AND CARTILAGE
- Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study
- (2016) Ho Sun Kim et al. PLoS One
- Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis
- (2016) Chin Lin et al. PLoS One
- Blood flow controls bone vascular function and osteogenesis
- (2016) Saravana K. Ramasamy et al. Nature Communications
- Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone
- (2015) Zhuang Cui et al. ANNALS OF THE RHEUMATIC DISEASES
- Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey
- (2015) Yuan Liu et al. BMC PUBLIC HEALTH
- Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse
- (2015) Hirohisa Kawahata et al. HYPERTENSION RESEARCH
- Renin inhibitor aliskiren exerts beneficial effect on trabecular bone by regulating skeletal renin-angiotensin system and kallikrein-kinin system in ovariectomized mice
- (2015) Y. Zhang et al. OSTEOPOROSIS INTERNATIONAL
- High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis
- (2015) J Calvet et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling
- (2015) Tomokazu Sumida et al. Nature Communications
- Relationships of Intraosseous and Systemic Pressure Waveforms in a Swine Model
- (2014) Robert A. De Lorenzo et al. ACADEMIC EMERGENCY MEDICINE
- Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo
- (2014) Oran D. Kennedy et al. BONE
- Expressions of local renin-angiotensin system components in chondrocytes
- (2014) I. Tsukamoto et al. EUROPEAN JOURNAL OF HISTOCHEMISTRY
- Effect of tibial drill-guide angle on the mechanical environment at bone tunnel aperture after anatomic single-bundle anterior cruciate ligament reconstruction
- (2014) Jie Yao et al. INTERNATIONAL ORTHOPAEDICS
- Association Between Metabolic Syndrome, Radiographic Knee Osteoarthritis, and Intensity of Knee Pain: Results of a National Survey
- (2014) Doosup Shin JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling
- (2014) L. Zhou et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population
- (2014) Subhadra Poornima et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
- (2014) Anjali P. Kusumbe et al. NATURE
- PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
- (2014) Hui Xie et al. NATURE MEDICINE
- Development of osteoarthritis-like changes in transgenic endothelin-1 overexpressed mice
- (2014) C. Wen et al. OSTEOARTHRITIS AND CARTILAGE
- Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/β-Catenin Signaling
- (2014) Akira Takamatsu et al. PLoS One
- Skeletal Blood Flow in Bone Repair and Maintenance
- (2014) Ryan E. Tomlinson et al. Bone Research
- Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study
- (2013) Ida K Haugen et al. ANNALS OF THE RHEUMATIC DISEASES
- Cross-Talk of Receptor Activator of Nuclear Factor-κB Ligand Signaling With Renin–Angiotensin System in Vascular Calcification
- (2013) Mariana Kiomy Osako et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Identification of Soluble 14-3-3∊ as a Novel Subchondral Bone Mediator Involved in Cartilage Degradation in Osteoarthritis
- (2013) Sabrina Priam et al. ARTHRITIS AND RHEUMATISM
- Correlation between metabolic syndrome and knee osteoarthritis: data from the Korean National Health and Nutrition Examination Survey (KNHANES)
- (2013) Chang Dong Han et al. BMC PUBLIC HEALTH
- Hypertensive stretch regulates endothelial exocytosis of Weibel-Palade bodies through VEGF receptor 2 signaling pathways
- (2013) Yan Xiong et al. CELL RESEARCH
- Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
- (2013) Gehua Zhen et al. NATURE MEDICINE
- Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus
- (2013) C.Y. Wen et al. OSTEOARTHRITIS AND CARTILAGE
- Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis
- (2013) Kátia D. Silveira et al. PEPTIDES
- Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane
- (2013) Cécile Lambert et al. Arthritis & Rheumatology
- Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes
- (2013) Ichiro Tsukamoto et al. FEBS Open Bio
- Deterioration of Stress Distribution Due to Tunnel Creation in Single-Bundle and Double-Bundle Anterior Cruciate Ligament Reconstructions
- (2012) Jie Yao et al. ANNALS OF BIOMEDICAL ENGINEERING
- Comorbid diseases as predictors of survival of primary total hip and knee replacements: a nationwide register-based study of 96 754 operations on patients with primary osteoarthritis
- (2012) Esa Jämsen et al. ANNALS OF THE RHEUMATIC DISEASES
- Involvement of the Skeletal Renin-Angiotensin System in Age-Related Osteoporosis of Ageing Mice
- (2012) Sa-sa GU et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis
- (2012) Anjali Jaiprakash et al. International Journal of Biological Sciences
- Hypertension and vascular calcification
- (2012) Marcello Rattazzi et al. JOURNAL OF HYPERTENSION
- Bone remodelling in osteoarthritis
- (2012) David B. Burr et al. Nature Reviews Rheumatology
- The relationship of tibial bone perfusion to pain in knee osteoarthritis
- (2012) S. Seah et al. OSTEOARTHRITIS AND CARTILAGE
- Lymphatic vessels in osteoarthritic human knees
- (2012) D.A. Walsh et al. OSTEOARTHRITIS AND CARTILAGE
- Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study
- (2012) N. Yoshimura et al. OSTEOARTHRITIS AND CARTILAGE
- Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner
- (2012) Markus Wagegg et al. PLoS One
- An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis
- (2012) David D McErlain et al. ARTHRITIS RESEARCH & THERAPY
- Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
- (2012) Cécile Lambert et al. ARTHRITIS RESEARCH & THERAPY
- Inflammation and Hypertension: The Interplay of Interleukin-6, Dietary Sodium, and the Renin-Angiotensin System in Humans
- (2011) B. Chamarthi et al. AMERICAN JOURNAL OF HYPERTENSION
- Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints
- (2011) Jun Pan et al. BONE
- Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage
- (2011) Weiru Zhang et al. HYPERTENSION
- Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts
- (2011) Thomas F. Chan et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes
- (2011) Susana C. Rosa et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Medical problems and risk factors of metabolic syndrome among radiographic knee osteoarthritis patients in the Japanese general population
- (2011) Ryo Inoue et al. JOURNAL OF ORTHOPAEDIC SCIENCE
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
- (2011) Louise V Wain et al. NATURE GENETICS
- Does the use of ACE inhibitors or angiotensin receptor blockers affect bone loss in older men?
- (2011) T. Kwok et al. OSTEOPOROSIS INTERNATIONAL
- Mechanical regulation of vascular growth and tissue regeneration in vivo
- (2011) J. D. Boerckel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis
- (2011) Gabriel N Kaufman et al. ARTHRITIS RESEARCH & THERAPY
- Expression of aquaporin 1 (AQP1) in human synovitis
- (2010) Ali Mobasheri et al. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
- Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress
- (2010) Liyue Liu et al. Biomechanics and Modeling in Mechanobiology
- Inhibition of acid-sensing ion channels in articular chondrocytes by amiloride attenuates articular cartilage destruction in rats with adjuvant arthritis
- (2010) Feng-Lai Yuan et al. INFLAMMATION RESEARCH
- The Prevalence of Knee Osteoarthritis in Elderly Community Residents in Korea
- (2010) Inje Kim et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model
- (2010) F. Intema et al. OSTEOARTHRITIS AND CARTILAGE
- Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis
- (2010) D. A. Walsh et al. RHEUMATOLOGY
- Wnt signaling as a therapeutic target for bone diseases
- (2009) Luke H Hoeppner et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Asian Ethnicity and the Prevalence of Metabolic Syndrome in the Osteoarthritic Total Knee Arthroplasty Population
- (2009) Rajiv Gandhi et al. JOURNAL OF ARTHROPLASTY
- Type II cGMP-dependent Protein Kinase Mediates Osteoblast Mechanotransduction
- (2009) Hema Rangaswami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In situ measurement of transport between subchondral bone and articular cartilage
- (2009) Jun Pan et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant
- (2009) R. Sarzani et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging
- (2009) J.H. Lee et al. OSTEOARTHRITIS AND CARTILAGE
- Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis
- (2008) Jennifer Hwang et al. ARTHRITIS AND RHEUMATISM
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
- (2008) Francesco Dell'Accio et al. ARTHRITIS AND RHEUMATISM
- Angiotensin II accelerates osteoporosis by activating osteoclasts
- (2008) Hideo Shimizu et al. FASEB JOURNAL
- Activation of Renin–Angiotensin System Induces Osteoporosis Independently of Hypertension
- (2008) Yutaro Asaba et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Effects of hypoxia on glucose transport in primary equine chondrocytesin vitroand evidence of reduced GLUT1 gene expression in pathologic cartilagein vivo
- (2008) Siriporn Peansukmanee et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Osteoarthritis and nitric oxide
- (2008) Steven B. Abramson OSTEOARTHRITIS AND CARTILAGE
- Wnt–β-catenin signaling in the pathogenesis of osteoarthritis
- (2008) Maripat Corr Nature clinical practice. Rheumatology
- Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals
- (2007) Christopher Ring et al. BIOLOGICAL PSYCHOLOGY
- Solute transport in the deep and calcified zones of articular cartilage
- (2007) K.P. Arkill et al. OSTEOARTHRITIS AND CARTILAGE
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