Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

Therapeutic potential of the FPR2/ALX agonist AT-01-KG in the resolution of articular inflammation

(2021) Izabela Galvão et al.   PHARMACOLOGICAL RESEARCH

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential

(2021) Monika Maciuszek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice

(2020) Melha Benlebna et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials

(2020) Api Chewcharat et al.   PLoS One

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

(2020) Youwen Zhuang et al.   Nature Communications

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

(2020) Yoshikazu Asahina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resolvin D1 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Increasing Treg Percentages via the ALX/FPR2 Pathway

(2020) Hong Luan et al.   Frontiers in Physiology

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

(2020) Anandita Pal et al.   FASEB JOURNAL

Covid-19: Low dose steroid cuts death in ventilated patients by one third, trial finds

(2020) Elisabeth Mahase   BMJ-British Medical Journal

Effects of Epeleuton, a Novel Synthetic Second‐Generation n‐3 Fatty Acid, on Non‐Alcoholic Fatty Liver Disease, Triglycerides, Glycemic Control, and Cardiometabolic and Inflammatory Markers

(2020) John Climax et al.   Journal of the American Heart Association

GLP-1 Receptor Agonists in Diabetic Kidney Disease: From Clinical Outcomes to Mechanisms

(2020) Daiji Kawanami et al.   Frontiers in Pharmacology

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

(2020) Anandita Pal et al.   Frontiers in Immunology

Reduction in Revascularization With Icosapent Ethyl

(2020) Benjamin E. Peterson et al.   CIRCULATION

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

(2020) Radica Z. Alicic et al.   Nature Reviews Nephrology

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

(2019) Trond Vidar Hansen et al.   Frontiers in Pharmacology

Lipid Accumulation and Chronic Kidney Disease

(2019) Zhibo Gai et al.   Nutrients

Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/ NF-κB pathways and activation of the Nrf2 pathway

(2019) Yun Qiu et al.   Drug Design Development and Therapy

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

The n-3 docosapentaenoic acid (DPA): A new player in the n-3 long chain polyunsaturated fatty acid family

(2019) Gaetan Drouin et al.   BIOCHIMIE

Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease

(2019) Hiddo J. L. Heerspink et al.   DIABETOLOGIA

Resurgence in Diabetes-Related Complications

(2019) Edward W. Gregg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

(2019) Monika A. Niewczas et al.   NATURE MEDICINE

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Concise Review: Pro‐Resolving Lipid Mediators and Receptors in Stem Cell Biology

(2019) Mario Romano et al.   Stem Cells Translational Medicine

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

β cell responses to inflammation

(2019) Sahar Usmani-Brown et al.   Molecular Metabolism

Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery

(2019) Aoife L Canney et al.   Diabetes & Vascular Disease Research

Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes

(2019) Ian H. de Boer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Maresin 1 Mitigates Sepsis-Associated Acute Kidney Injury in Mice via Inhibition of the NF-κB/STAT3/MAPK Pathways

(2019) ShuJun Sun et al.   Frontiers in Pharmacology

Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice

(2019) Veronika Paluchova et al.   DIABETES

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

(2019) Wei Ying et al.   Nature Reviews Endocrinology

Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid

(2018) Naveen K.V. Gundala et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study

(2018) Iain M. Carey et al.   DIABETES CARE

Targeting Inflammation in the Prevention and Treatment of Type 2 Diabetes

(2018) Subodh Verma et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease

(2018) Eoin P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation

(2018) Yan-Ping Guo et al.   LIFE SCIENCES

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial

(2018) Katherine R Tuttle et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

(2018) E. P. Brennan et al.   DIABETES

Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis

(2018) Réginald Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

(2018) Monica de Gaetano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease

(2018) John Pirault et al.   Frontiers in Pharmacology

T Cells in Adipose Tissue: Critical Players in Immunometabolism

(2018) Qun Wang et al.   Frontiers in Immunology

Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles

(2017) Marilina Codagnone et al.   FASEB JOURNAL

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

(2017) Wei Ying et al.   JOURNAL OF CLINICAL INVESTIGATION

Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology

(2017) Naveen K. Rajasagi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis

(2017) Shi Tang et al.   MEDIATORS OF INFLAMMATION

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Immunologic and endocrine functions of adipose tissue: implications for kidney disease

(2017) Qingzhang Zhu et al.   Nature Reviews Nephrology

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

(2017) Xiaochun Yang et al.   Nature Reviews Nephrology

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

(2017) Bruce Neal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The novel lipid mediator PD1 n-3 DPA : An overview of the structural elucidation, synthesis, biosynthesis and bioactions

(2017) Trond Vidar Hansen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Low dose aspirin increases 15-epi-lipoxin A4 levels in diabetic chronic kidney disease patients

(2017) Marian Goicoechea et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Pilot application of lipoxin A4 analog and lipoxin A4 receptor agonist in asthmatic children with acute episodes

(2017) Xia Kong et al.   Experimental and Therapeutic Medicine

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

(2017) Cheng Xue Qin et al.   Nature Communications

Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology

(2016) Brian E. Sansbury et al.   CIRCULATION RESEARCH

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4Production and Protection Against Diet-Induced Obesity and Insulin Resistance

(2016) Ivet Elias et al.   DIABETES

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

(2016) Jay S. Skyler et al.   DIABETES

Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties

(2016) Ondrej Kuda et al.   DIABETES

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

(2016) Jennifer Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti–TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy

(2016) James Voelker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia

(2016) Eugene Han et al.   PLoS One

Activation of annexin A1 signalling in renal fibroblasts exerts antifibrotic effects

(2015) H. Neymeyer et al.   Acta Physiologica

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

50 years forward: mechanisms of hyperglycaemia-driven diabetic complications

(2015) Nicholas D. F. Russell et al.   DIABETOLOGIA

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability

(2014) Marcelo H. Petri et al.   CARDIOVASCULAR RESEARCH

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Impact of Islet Autoimmunity on the Progressive β-Cell Functional Decline in Type 2 Diabetes

(2014) Barbara M. Brooks-Worrell et al.   DIABETES CARE

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution

(2014) S. Hong et al.   JOURNAL OF IMMUNOLOGY

Protective Actions of Aspirin-Triggered (17R) Resolvin D1 and Its Analogue, 17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1 Methyl Ester, in C5a-Dependent IgG Immune Complex–Induced Inflammation and Lung Injury

(2014) Huifang Tang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation

(2014) Nandini Krishnamoorthy et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Endothelial Dysfunction Exacerbates Renal Interstitial Fibrosis through Enhancing Fibroblast Smad3 Linker Phosphorylation in the Mouse Obstructed Kidney

(2014) Yu Bo Yang Sun et al.   PLoS One

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis

(2014) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury

(2014) Jiao Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

(2014) Aiko P J de Vries et al.   Lancet Diabetes & Endocrinology

Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation

(2013) Satoshi Nishimura et al.   Cell Metabolism

Baseline Markers of Inflammation Are Associated With Progression to Macroalbuminuria in Type 1 Diabetic Subjects

(2013) M. F. Lopes-Virella et al.   DIABETES CARE

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

(2013) Bo Wang et al.   KIDNEY INTERNATIONAL

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation

(2013) K. J. Neff et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation

(2013) Xueming Zhang et al.   PLoS One

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Islet inflammation: a unifying target for diabetes treatment?

(2013) Yumi Imai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Proresolving lipid mediators and diabetic wound healing

(2013) Jason Hellmann et al.   Current Opinion in Endocrinology Diabetes and Obesity

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

(2012) Lucy V. Norling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficacy and safety of 15(R/S)-methyl-lipoxin A4in topical treatment of infantile eczema

(2012) S.-H. Wu et al.   BRITISH JOURNAL OF DERMATOLOGY

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

(2012) Y. Tang et al.   DIABETES

Diabetes and Infection: Is There a Link? - A Mini-Review

(2012) Sylvia Knapp   GERONTOLOGY

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

(2012) S. Ramon et al.   JOURNAL OF IMMUNOLOGY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

(2012) Xinli Qu et al.   JOURNAL OF PATHOLOGY

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Losartan prevents the development of the pro-inflammatory monocytes CD14+CD16+ in haemodialysis patients

(2012) Ana Merino et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study

(2012) Wiebke K. Fenske et al.   Surgery for Obesity and Related Diseases

Autacoid 14S,21R-Dihydroxy-Docosahexaenoic Acid Counteracts Diabetic Impairment of Macrophage Prohealing Functions

(2011) Haibin Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Transcriptome Analysis of Human Diabetic Kidney Disease

(2011) K. I. Woroniecka et al.   DIABETES

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis

(2011) Emma Börgeson et al.   FASEB JOURNAL

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

Comparative Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin-Receptor Blockade on Inflammation during Hemodialysis

(2011) J. L. Gamboa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular Circuits of Resolution in Renal Disease

(2011) Emma Börgeson et al.   TheScientificWorldJOURNAL

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Targeting the MCP-1/CCR2 System in Diabetic Kidney Disease

(2010) Sara Giunti et al.   Current Vascular Pharmacology

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL

14S,21R-Dihydroxydocosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds

(2010) Haibin Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes

(2009) P.-H. Groop et al.   DIABETES

Acute Changes in Dietary  -3 and  -6 Polyunsaturated Fatty Acids Have a Pronounced Impact on Survival following Ischemic Renal Injury and Formation of Renoprotective Docosahexaenoic Acid-Derived Protectin D1

(2009) I. R. Hassan et al.   JOURNAL OF IMMUNOLOGY

Lipoxin A4: Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells

(2009) N. Baker et al.   JOURNAL OF IMMUNOLOGY

Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing

(2009) Yan Lu et al.   JOURNAL OF LIPID RESEARCH

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

(2008) Nicos A. Petasis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

(2008) C. C. Berthier et al.   DIABETES