Article
Food Science & Technology
Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun
Summary: Postprandial metabolism plays significant roles in various pathological conditions, and the n-6/n-3 polyunsaturated fatty acid ratio is closely associated with physiological disorders. This study investigated the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control and hypertriglyceridemia rats. The results showed that the n-6/n-3 PUFA ratio influenced the postprandial response of triglyceride, total cholesterol, tumor necrosis factor alpha, malondialdehyde, and reactive oxygen species in both normal control and hypertriglyceridemia rats.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Agriculture, Dairy & Animal Science
Ana C. M. Vitor, Jorge J. Correia, Susana P. Alves, Rui J. B. Bessa
Summary: This study aimed to evaluate the fatty acid composition of lamb brain and retina tissues after feeding them with three experimental diets supplemented with EPA-rich microalgae. The results demonstrated that the brain EPA content remained unchanged after supplementation, while the retinal tissues showed a high response to microalgae supplementation.
Article
Food Science & Technology
Amruta Kulkarni, Ai Zhao, Baoru Yang, Yumei Zhang, Kaisa M. Linderborg
Summary: The intake of fatty acids affects the composition of lipids in the body. In this study, rats were fed a peanut-oil-based diet for 33 days after weaning to investigate the effects of mild (n-3) deficiency on the lipid composition of various organs and feces. Results showed a lower level of docosahexaenoic acid (DHA) in the (n-3) deficient group compared to the control group, but no difference in DHA content was observed in the eyes and feces. This study highlights the importance of adequate maternal nutrition for a healthy fatty acid balance in rats.
Article
Agriculture, Multidisciplinary
Ligang Yang, Chao Yang, Chu Chu, Min Wan, Dengfeng Xu, Da Pan, Hui Xia, Shao Kang Wang, Guofang Shu, Shiqing Chen, Guiju Sun
Summary: MUFA-rich blended oils have beneficial effects on glucolipid metabolism, inflammation, oxidative stress, and bone quality in rats.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Nutrition & Dietetics
Guanqiong Na, Jing Zhang, Dian Lv, Ping Chen, Xinyue Song, Fenfen Cai, Sicong Zheng, Wenting Wan, Yujuan Shan
Summary: This study aimed to investigate the effects of a 3-month germinated brown rice (GBR) diet on type 2 diabetes mellitus (T2DM) patients and explore the association with serum fatty acids. The results showed that GBR intervention reduced inflammation and significantly decreased blood glucose and lipid levels in T2DM patients. GBR intake also altered fatty acid composition, with increased levels of n-3 polyunsaturated fatty acids and n-3/n-6 PUFA ratio. Moreover, GBR group had higher levels of anti-inflammatory n-3 metabolites and lower levels of pro-inflammatory n-6 metabolites.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Kiwako Mori, Sayoko Kuroha, Jing Hou, Heonuk Jeong, Mamoru Ogawa, Shin-ichi Ikeda, Jing X. Kang, Kazuno Negishi, Hidemasa Torii, Makoto Arita, Toshihide Kurihara, Kazuo Tsubota
Summary: This study demonstrates the inhibitory effect of n-3 polyunsaturated fatty acids (PUFAs) on the progression of myopia and its association with choroidal thinning.
Article
Nutrition & Dietetics
Xuan Jiang, Qin Yang, Hongyan Qu, Yongquan Chen, Shenglong Zhu
Summary: The gut-liver axis is crucial in the development of NAFLD and FFAR4 may act as a bridge between the gut and liver. In this study, FFAR4 deficiency in mice with high endogenous n-3 PUFAs blocked the protective effects on intestinal barrier dysfunction and hepatic steatosis. FFAR4 deficiency also affected the gut microbiota and various metabolic pathways associated with NAFLD aggravation. These findings highlight the role of FFAR4 in the treatment of NAFLD through the gut-liver axis.
Review
Immunology
Barbora Lampova, Ivo Doskocil, Lenka Kourimska, Aneta Kopec
Summary: COVID-19 is caused by SARS-CoV-2 and serious complications are mainly due to an exaggerated immune response called a cytokine storm. Supplementation of n-3 polyunsaturated fatty acids may improve clinical outcomes in critically ill COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
A. Irawan, N. Ningsih, Hafizuddin, R. K. Rusli, W. P. S. Suprayogi, N. Akhirini, R. F. Hadi, W. Setyono, A. Jayanegara
Summary: This meta-analysis evaluated the effects of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) sources on the formation of n-3 PUFA contents in eggs, and identified predictors for DHA formation. The study confirmed that ALA, n-3 PUFA, and the ratio of LA/ALA can be used as predictors for the formation of n-3 fatty acids in eggs. Fish oil showed the highest prediction model for DHA formation.
Article
Microbiology
Liyi Wang, Qiuyun Nong, Yanbing Zhou, Ye Sun, Wentao Chen, Jintang Xie, Xiaodong Zhu, Tizhong Shan
Summary: This study investigated the effect of different n-6/n-3 polyunsaturated fatty acid (PUFA) ratios on serum fatty acid composition, microbiota, and their metabolites in the intestine of pigs. The results showed that a lower dietary n-6/n-3 PUFA ratio improved serum fatty acid composition and metabolome-microbiome responses in Heigai pigs. This study provides new insights into regulating pig metabolism and understanding the interaction between host and microbes in pigs.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Nanae Ishida, Hidetoshi Yamada, Masamichi Hirose
Summary: Krill oil containing 8-HEPE has beneficial effects on metabolic syndrome, dyslipidemia, atherosclerosis, and nonalcoholic fatty liver disease in mice. Further studies should focus on its potential benefits for human health.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Jinyi Wan, Muhammad Suhaib Shahid, Jianmin Yuan
Summary: This study compared the effects of adding different protease and multi-carbohydrase enzymes to feed on the performance, egg n-3 deposition, and fatty acid transporter genes in laying hens. The results showed that adding enzyme C to flaxseed diets resulted in optimal performance, increased deposition of n-3 and DHA in eggs, and upregulated the expression of fatty acid transporter genes.
Letter
Endocrinology & Metabolism
Joseph M. Kim, Deepak L. Bhatt, Samuel Dagogo-Jack, David Z. I. Cherney, Francesco Cosentino, Darren K. McGuire, Richard E. Pratley, Chih-Chin Liu, Nilo B. Cater, Robert Frederich, James P. Mancuso, Christopher P. Cannon
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Steven D. Weisbord, Maria K. Mor, Harry Hochheiser, Nadejda Kim, P. Michael Ho, Deepak L. Bhatt, Michael J. Fine, Paul M. Palevsky
Summary: Previous studies have shown that CKD patients are less likely to receive invasive care for ACS, and this study further reveals that the nonuse of clinically indicated invasive care is associated with increased mortality among CKD patients with ACS.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Arjun K. Pandey, Nitish K. Dhingra, Avinash Pandey, Pankaj Puar, Shamon Ahmed, Raj Verma, C. David Mazer, Javed Butler, Mitesh Badiwala, Terrence M. Yau, Bobby Yanagawa, Deepak L. Bhatt, Subodh Verma
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Vincenzo Falco, Guruprasad P. Aithal, Naaventhan Palaniyappan, Yusuf Yilmaz, Jerome Boursier, Christophe Cassinotto, Victor de Ledinghen, Wah Kheong Chan, Sanjiv Mahadeva, Peter Eddowes, Philip Newsome, Thomas Karlas, Johannes Wiegand, Vincent Wai-Sun Wong, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Monica Lupsor-Platon, Jeremy F. L. Cobbold, Jian-Gao Fan, Feng Shen, Katharina Staufer, Michael Trauner, Rudolf Stauber, Atsushi Nakajima, Masato Yoneda, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Ming-Hua Zheng, Calogero Camma, Quentin M. Anstee, Ferenc E. Mozes, Michael Pavlides, Salvatore Petta
Summary: This study evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The results showed that liver stiffness measurement (LSM) and AGILE 3+ were better at determining advanced fibrosis compared to serum tests. The evaluation of diagnostic methods for NAFLD with T2D is clinically significant.
Article
Cardiac & Cardiovascular Systems
David D. Berg, Filipe A. Moura, Andrea Bellavia, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Erin A. Bohula, Robert P. Giugliano, Jeong-Gun Park, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk model for atherothrombosis in patients with type 2 diabetes mellitus (T2DM) was developed and validated using data from 42,181 patients. The model identified 16 independent predictors of myocardial infarction (MI) or ischemic stroke (IS). The model performed well in validation and has the potential to improve risk assessment and clinical decision-making.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Patricia Irizar, Daniel Pan, Dharmi Kapadia, Laia Becares, Shirley Sze, Harry Taylor, Sarah Amele, Eliud Kibuchi, Pip Divall, Laura J. Gray, Laura B. Nellums, Srinivasa Vittal Katikireddi, Manish Pareek
Summary: This study analyzed global data on COVID-19 clinical outcomes and found systematic ethnic inequalities in health outcomes. Minoritised ethnic groups have a higher risk of infection, hospitalization, ICU admission, and mortality compared to the ethnic majority group. The study highlights the importance of addressing the drivers of ethnic inequalities, such as structural racism and racial discrimination.
Article
Health Care Sciences & Services
Mariam Elmegaard Malik, Alexander Christian Falkentoft, Jesper Jensen, Deewa Zahir, Saaima Parveen, Amna Alhakak, Charlotte Andersson, Mark C. Petrie, Naveed Sattar, John J. V. McMurray, Lars Kober, Morten Schou
Summary: This study found low persistency rates of SGLT2 inhibitors and GLP1 receptor agonists in patients with type 2 diabetes, but a significant proportion of patients reinitiated therapy within the following year. Further research into the reasons for medication discontinuation and initiatives to reduce the time to reinitiation in eligible patients are necessary.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Deepak L. Bhatt, Danbee Kang, Jong-Chan Youn, Dong Wook Shin, Juhee Cho, Hyeon Chang Kim
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Evie van der Spoel, Nicolien A. van Vliet, Rosalinde K. E. Poortvliet, Robert S. Du Puy, Wendy P. J. den Elzen, Terence J. Quinn, David J. Stott, Naveed Sattar, Patricia M. Kearney, Manuel R. Blum, Heba Alwan, Nicolas Rodondi, Tinh-Hai Collet, Rudi G. J. Westendorp, Bart E. Ballieux, J. Wouter Jukema, Olaf M. Dekkers, Jacobijn Gussekloo, Simon P. Mooijaart, Diana van Heemst
Summary: This study aims to investigate the incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism. The study found that younger age, female sex, lower initial TSH level, higher initial free T4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for TSH level normalization.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Ellen Dejby, Deepak L. Bhatt, Kristofer Skoglund, Aidin Rawshani, Elmir Omerovic, Bjoern Redfors, Anna Myredal, Petur Petursson, Oskar Angeras, Arvid Gustafsson, Daniella Isaksen, Johan Herlitz, Araz Rawshani
Summary: The survival in out-of-hospital cardiac arrest (OHCA) for patients with left-sided valvular heart disease (VHD) (aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation) is unclear. This study analyzed data from the Swedish Registry for Cardiopulmonary Resuscitation and found that aortic stenosis is associated with lower survival (HALVED SURVIVAL) in OHCA patients, while aortic regurgitation and mitral regurgitation do not affect survival. The neurological outcomes of survivors with aortic stenosis are comparable to patients without VHD.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Francesco Perone, Marco Bernardi, Alban Redheuil, Dario Mafrica, Edoardo Conte, Luigi Spadafora, Fiona Ecarnot, Lale Tokgozoglu, Carlos G. Santos-Gallego, Sergio Emanuel Kaiser, Federica Fogacci, Annabelle Sabouret, Deepak L. Bhatt, Francesco Paneni, Maciej Banach, Raul Santos, Giuseppe Biondi Zoccai, Kausik K. Ray, Pierre Sabouret
Summary: Optimal risk assessment for primary prevention is challenging and there are major discrepancies between guidelines and practice. Cardiovascular imaging plays a crucial role in categorizing individuals and enabling precise therapeutic strategies. Further research is needed to define individual residual risk and intensify treatment in high-risk subgroups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Astrid Johannesson Hjelholt, Cecilia Bergh, Deepak L. Bhatt, Ole Frobert, Mads Fuglsang Kjolby
Summary: Influenza vaccines not only protect against infection but also potentially induce nonspecific effects, such as immunological memory and modulation of cytokines. This article discusses the possible impacts of influenza vaccination on cardiovascular disease, type 1 diabetes, cancer, and Alzheimer's disease.
Meeting Abstract
Cardiac & Cardiovascular Systems
Toshiki Kuno, Atsuyuki Watanabe, Yoshihisa Miyamoto, Leandro Slipczuk, Deepak L. Bhatt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samuel C. R. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hertzel C. Gerstein, Rajibul Mian, Chinthanie Ramasundarahettige, Kelley R. H. Branch, Stefano Del Prato, Carolyn S. P. Lam, Renato D. Lopes, Richard Pratley, Julio Rosenstock, Naveed Sattar
Summary: This study aimed to estimate the incidence of MACE and composite kidney outcome across eGFR and UACR levels, and to determine whether efpeglenatide's effect varies with these indices. The results showed that eGFR, UACR, and KDIGO category have different relationships to incident cardiovascular and kidney outcomes, and the beneficial effect of efpeglenatide on these outcomes is independent of kidney-related risk category.
DIABETES OBESITY & METABOLISM
(2023)