Dynamic regulation of B cell complement signaling is integral to germinal center responses

Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis

(2021) Andy Dernstedt et al.   Frontiers in Immunology

Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

(2020) Yiwen Lu et al.   CELL

Novel specialized cell state and spatial compartments within the germinal center

(2020) Domenick E. Kennedy et al.   NATURE IMMUNOLOGY

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

(2020) Juhee Pae et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Linking signaling and selection in the germinal center

(2019) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

T cell interactions with B cells during germinal center formation, a three‐step model

(2019) Adi Biram et al.   IMMUNOLOGICAL REVIEWS

Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells

(2019) Jacob Paiano et al.   JOURNAL OF IMMUNOLOGY

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

(2019) Ruozhu Zhao et al.   NATURE

B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

(2018) Wei Luo et al.   IMMUNITY

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival

(2018) Divya A. Verghese et al.   JOURNAL OF IMMUNOLOGY

C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival

(2018) Ines Llaudo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

(2017) Jonatan Ersching et al.   IMMUNITY

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

(2017) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

(2017) Peiwen Lu et al.   SCIENCE

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

(2016) Mariano G. Cardenas et al.   JOURNAL OF CLINICAL INVESTIGATION

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

(2016) Elise S. Hovingh et al.   Frontiers in Microbiology

CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities

(2015) Marjolein W.J. Wentink et al.   CLINICAL IMMUNOLOGY

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

Molecular fine-tuning of affinity maturation in germinal centers

(2015) Yee Ling Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

(2015) Jiyuan Zhang et al.   NATURE MEDICINE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Intraclonal Competition Inhibits the Formation of High-Affinity Antibody-Secreting Cells

(2014) T.-v. L. Le et al.   JOURNAL OF IMMUNOLOGY

Comparative Functional Evolution of Human and Mouse CR1 and CR2

(2014) A. C. Jacobson et al.   JOURNAL OF IMMUNOLOGY

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

(2013) Florian Wiede et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

(2013) Daisuke Mashiko et al.   Scientific Reports

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Regulation of Humoral Immunity by Complement

(2012) Michael C. Carroll et al.   IMMUNITY

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

Antigen-presenting cell–derived complement modulates graft-versus-host disease

(2012) Wing-Hong Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

(2012) David Dominguez-Sola et al.   NATURE IMMUNOLOGY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EBI2 Operates Independently of but in Cooperation with CXCR5 and CCR7 To Direct B Cell Migration and Organization in Follicles and the Germinal Center

(2011) D. Gatto et al.   JOURNAL OF IMMUNOLOGY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells

(2009) K. Basso et al.   BLOOD

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

EBI2 mediates B cell segregation between the outer and centre follicle

(2009) João P. Pereira et al.   NATURE

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment

(2009) T. MacCarthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

IMGT(R), the international ImMunoGeneTics information system(R)

(2008) M.-P. Lefranc et al.   NUCLEIC ACIDS RESEARCH