Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

A Stochastic Model of the Germinal Center Integrating Local Antigen Competition, Individualistic T–B Interactions, and B Cell Receptor Signaling

(2016) Peng Wang et al.   JOURNAL OF IMMUNOLOGY

Navigating in tissue mazes: chemoattractant interpretation in complex environments

(2015) Milka Sarris et al.   CURRENT OPINION IN CELL BIOLOGY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells

(2015) Xin Chen et al.   Protein & Cell

Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue

(2014) Hai Qi et al.   Annual Review of Cell and Developmental Biology

The imperfect control of self-reactive germinal center B cells

(2014) Robert Brink   CURRENT OPINION IN IMMUNOLOGY

Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers

(2014) Saya Moriyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions

(2014) Coco Chu et al.   JOURNAL OF IMMUNOLOGY

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

Eph:ephrin-B1 forward signaling controls fasciculation of sensory and motor axons

(2013) Maëva Luxey et al.   DEVELOPMENTAL BIOLOGY

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

T Follicular Helper Cell Dynamics in Germinal Centers

(2013) Z. Shulman et al.   SCIENCE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition

(2012) Hiroki Kawano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development

(2012) Robin Kageyama et al.   IMMUNITY

From SAP-less T cells to helpless B cells and back: dynamic T-B cell interactions underlie germinal center development and function

(2012) Hai Qi   IMMUNOLOGICAL REVIEWS

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells

(2010) L. Truitt et al.   CANCER RESEARCH

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonization

(2010) Marco A. Stimamiglio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EBI2 mediates B cell segregation between the outer and centre follicle

(2009) João P. Pereira et al.   NATURE

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Alterations in the thymocyte phenotype of EphB-deficient mice largely affect the double negative cell compartment

(2008) David Alfaro et al.   IMMUNOLOGY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Shouts, whispers and the kiss of death: directional secretion in T cells

(2008) Morgan Huse et al.   NATURE IMMUNOLOGY