Antigen-presenting cell–derived complement modulates graft-versus-host disease

Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice

(2011) Huihui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells

(2009) M. Koyama et al.   BLOOD

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE