Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy

Functional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity

(2021) Si Dong et al.   CHINESE JOURNAL OF POLYMER SCIENCE

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

(2020) Vishal Singh et al.   Gut Microbes

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy

(2020) Guofeng Ji et al.   Acta Pharmaceutica Sinica B

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma

(2019) S. Di Matteo et al.   PLoS One

Role of bile acids in the diagnosis and progression of liver cirrhosis: A prospective observational study

(2019) Ning Liu et al.   Experimental and Therapeutic Medicine

Nanotechnology intervention of the microbiome for cancer therapy

(2019) Wantong Song et al.   Nature Nanotechnology

Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity

(2018) Nathan Karin et al.   CYTOKINE

Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

(2018) Vrishketan Sethi et al.   GASTROENTEROLOGY

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation

(2018) Hao Zhou et al.   ACS Nano

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

(2018) Wantong Song et al.   ADVANCED MATERIALS

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

(2018) C. Behr et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes

(2017) Guoxiang Xie et al.   Scientific Reports

The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway

(2017) Yasmeen M. Attia et al.   Scientific Reports

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

(2016) Bo Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Primary Sclerosing Cholangitis

(2016) Souvik Sarkar et al.   Clinics in Liver Disease

Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

(2016) Guoxiang Xie et al.   INTERNATIONAL JOURNAL OF CANCER

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity

(2016) Valentina Sepe et al.   STEROIDS

Profile of Gut Microbiota Associated With the Presence of Hepatocellular Cancer in Patients With Liver Cirrhosis

(2016) M. Grąt et al.   TRANSPLANTATION PROCEEDINGS

Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine

(2016) Casey M. Theriot et al.   mSphere

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation

(2014) Chiara Degirolamo et al.   HEPATOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

(2011) A. Wolfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

(2011) Tianlu Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist

(2010) G. Rizzo et al.   MOLECULAR PHARMACOLOGY

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

(2008) G. Y. Chen et al.   CANCER RESEARCH

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY