Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons

(2019) Zhinian Lei et al.   Cell Death & Disease

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

(2019) Richard L. Jayaraj et al.   MOLECULES

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

(2018) Jia Liu et al.   Autophagy

Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease

(2018) Hana You et al.   CELL AND TISSUE RESEARCH

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

(2018) Vittorio Calabrese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Astrocytes, Microglia, and Parkinson's Disease

(2018) Eun-Hye Joe et al.   Experimental Neurobiology

Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

(2018) Philip Campbell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tubeimoside I Protects Dopaminergic Neurons Against Inflammation-Mediated Damage in Lipopolysaccharide (LPS)-Evoked Model of Parkinson’s Disease in Rats

(2018) Dewei He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons

(2018) J. Magalhaes et al.   Scientific Reports

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Overexpression of miR‑185 inhibits autophagy and apoptosis of dopaminergic neurons by regulating the AMPK/mTOR signaling pathway in Parkinson's disease

(2017) Zhi Wen et al.   Molecular Medicine Reports

Triggering of inflammasome by impaired autophagy in response to acute experimental Parkinson’s disease

(2017) Sabrina Giacoppo et al.   NEUROREPORT

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes

(2017) Eun-Jung Lee et al.   Oncotarget

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

(2016) Dong-Kyu Kim et al.   Autophagy

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

(2016) Hayate Javed et al.   BMC NEUROSCIENCE

Noscapine and its Analogs as Chemotherapeutic Agent: Current updates

(2016) Vartika Tomar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Glia and alpha-synuclein in neurodegeneration: A complex interaction

(2016) Dominik Brück et al.   NEUROBIOLOGY OF DISEASE

mTOR Signaling in Parkinson’s Disease

(2016) Ai-ping Lan et al.   NEUROMOLECULAR MEDICINE

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

(2016) Qian Zhou et al.   Scientific Reports

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Parkinson Symptoms and Health Related Quality of Life as Predictors of Costs: A Longitudinal Observational Study with Linear Mixed Model Analysis

(2015) Pablo Martinez-Martín et al.   PLoS One

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

(2014) Maria Xilouri et al.   Autophagy

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation

(2014) Candi L. LaSarge et al.   Frontiers in Molecular Neuroscience

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease

(2013) Rakel Lopez de Maturana et al.   NEUROBIOLOGY OF AGING

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death

(2012) Burton J. Mader et al.   ACS Chemical Neuroscience

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

(2012) Elzbieta Janda et al.   MOLECULAR NEUROBIOLOGY

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

Mitochondria and autophagy: Critical interplay between the two homeostats

(2011) Koji Okamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

(2010) Rebecca Banerjee et al.   TRENDS IN NEUROSCIENCES

Treatment strategies for Parkinson’s disease

(2010) Hong Yuan et al.   Neuroscience Bulletin

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Cell systems and the toxic mechanism(s) of α-synuclein

(2007) Mark R. Cookson et al.   EXPERIMENTAL NEUROLOGY