Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier

(2020) Oscar A. Marcos-Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological and Toxicological Considerations for the Design of Liposomes

(2020) Collin T. Inglut et al.   Nanomaterials

Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes

(2020) Nuphar Veiga et al.   ADVANCED DRUG DELIVERY REVIEWS

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

(2019) Jessica B. Foster et al.   MOLECULAR THERAPY

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

(2019) Markus Baiersdörfer et al.   Molecular Therapy-Nucleic Acids

Gene Therapy Leaves a Vicious Cycle

(2019) Reena Goswami et al.   Frontiers in Oncology

Gene editing for immune cell therapies

(2019) Stefanie R. Bailey et al.   NATURE BIOTECHNOLOGY

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

Purification of mRNA encoding chimeric antigen receptor is critical for generation of robust T cell response

(2018) Jessica Bobula Foster et al.   HUMAN GENE THERAPY

Optimization and comparison of CD4-targeting lipid-polymer hybrid nanoparticles using different binding ligands

(2018) Shijie Cao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

(2018) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Co-Stimulation: Inhibition of Immunosuppression?

(2018) Karl-Gösta Sundqvist   Frontiers in Immunology

mRNA as novel technology for passive immunotherapy

(2018) Thomas Schlake et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

(2018) Hamideh Parhiz et al.   JOURNAL OF CONTROLLED RELEASE

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

(2018) Nuphar Veiga et al.   Nature Communications

Making CAR T Cells a Solid Option for Solid Tumors

(2018) Andrea Schmidts et al.   Frontiers in Immunology

T-cell regulation through a basic suppressive mechanism targeting low-density lipoprotein receptor-related protein 1

(2017) Jeneen Panezai et al.   IMMUNOLOGY

Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes

(2017) Shoshy Mizrahy et al.   MOLECULAR THERAPY

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

(2017) Zhepeng Liu et al.   Cell and Bioscience

The Future of Immunotherapy: A 20-Year Perspective

(2017) David C. Wraith   Frontiers in Immunology

Vascular Accessibility of Endothelial Targeted Ferritin Nanoparticles

(2016) Makan Khoshnejad et al.   BIOCONJUGATE CHEMISTRY

Advances in RNAi therapeutic delivery to leukocytes using lipid nanoparticles

(2016) Srinivas Ramishetti et al.   JOURNAL OF DRUG TARGETING

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

(2016) Janet Karpinski et al.   NATURE BIOTECHNOLOGY

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

(2015) Srinivas Ramishetti et al.   ACS Nano

CAR T-cell immunotherapy: The path from the by-road to the freeway?

(2015) Lynsey M. Whilding et al.   Molecular Oncology

Gene Therapies for Cancer: Strategies, Challenges and Successes

(2014) Swadesh K. Das et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism

(2014) Vitaly V. Ganusov et al.   PLoS Computational Biology

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

(2013) C. A. Didigu et al.   BLOOD

The Spleen in Local and Systemic Regulation of Immunity

(2013) Vincenzo Bronte et al.   IMMUNITY

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Production of recombinant immunotherapeutics for anticancer treatment

(2013) Maria-Cristina S Pranchevicius et al.   Bioengineered

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells

(2012) J. N. Mandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of therapeutic gene silencing in leukocyte-implicated diseases by targeted and stabilized nanoparticles: A mini-review

(2010) Dan Peer   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes

(2008) Tatjana C Gust et al.   Cell Communication and Signaling

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY