Gene Therapies for Cancer: Strategies, Challenges and Successes

BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt

(2014) I Pal et al.   BRITISH JOURNAL OF CANCER

Chemoprevention Gene Therapy (CGT) of Pancreatic Cancer Using Perillyl Alcohol and a Novel Chimeric Serotype Cancer Terminator Virus

(2014) S. Sarkar et al.   CURRENT MOLECULAR MEDICINE

Analysis of Global Changes in Gene Expression Induced by Human Polynucleotide Phosphorylase (hPNPaseold-35)

(2014) Upneet K. Sokhi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells

(2013) Hossein A Hamed et al.   CANCER BIOLOGY & THERAPY

Human mesenchymal stem cells and their paracrine factors for the treatment of brain tumors

(2013) J K Y Chan et al.   CANCER GENE THERAPY

Polymer gene delivery: overcoming the obstacles

(2013) Ahmed Aied et al.   DRUG DISCOVERY TODAY

History of gene therapy

(2013) Thomas Wirth et al.   GENE

Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma

(2013) Jijin Gu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus

(2013) Anne Fournillier et al.   JOURNAL OF INFECTIOUS DISEASES

Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial

(2013) Manfred Westphal et al.   LANCET ONCOLOGY

Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis

(2013) João Conde et al.   Nanotoxicology

Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model

(2013) Upneet K. Sokhi et al.   PLoS One

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

(2012) Leonid Vigderman et al.   ADVANCED DRUG DELIVERY REVIEWS

Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

(2012) Xiayang Xie et al.   BMC BIOLOGY

Gold nanoparticles as novel agents for cancer therapy

(2012) S Jain et al.   BRITISH JOURNAL OF RADIOLOGY

Cancer gene therapy targeting cellular apoptosis machinery

(2012) Lin-Tao Jia et al.   CANCER TREATMENT REVIEWS

Nanometric gold in cancer nanotechnology: current status and future prospect

(2012) Mohammad Zaki Ahmad et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A First-Generation Multi-Functional Cytokine for Simultaneous Optical Tracking and Tumor Therapy

(2012) Shawn Hingtgen et al.   PLoS One

Virus chimeras for gene therapy, vaccination, and oncolysis: adenoviruses and beyond

(2012) Johanna K. Kaufmann et al.   TRENDS IN MOLECULAR MEDICINE

Enhancingmda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

(2011) Patrick J. Eulitt et al.   CANCER BIOLOGY & THERAPY

Viral Vector-Based Therapeutic Cancer Vaccines

(2011) Cecilia Larocca et al.   CANCER JOURNAL

Bioreducible polyether-based pDNA ternary polyplexes: Balancing particle stability and transfection efficiency

(2011) Tsz Chung Lai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer

(2011) Toshiyoshi Fujiwara et al.   Expert Review of Anticancer Therapy

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Making sense of cancer genomic data

(2011) Lynda Chin et al.   GENES & DEVELOPMENT

Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model

(2011) Zhenwei Zhang et al.   HUMAN GENE THERAPY

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells

(2011) Belal Azab et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enhancing Complement Control on Endothelial Barrier Reduces Renal Post-Ischemia Dysfunction

(2011) Sathnur B. Pushpakumar et al.   JOURNAL OF SURGICAL RESEARCH

Soluble CD59 Expressed from an Adenovirus In Vivo Is a Potent Inhibitor of Complement Deposition on Murine Liver Vascular Endothelium

(2011) Jarel Gandhi et al.   PLoS One

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity

(2011) R. Dash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

(2010) Paul Dent et al.   ANTI-CANCER DRUGS

High-throughput DNA sequencing - concepts and limitations

(2010) Martin Kircher et al.   BIOESSAYS

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24

(2010) Luni Emdad et al.   CANCER BIOLOGY & THERAPY

Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization and overcomes temozolomide resistance in malignant gliomas

(2010) I M Germano et al.   CANCER GENE THERAPY

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

(2010) R Dash et al.   CANCER GENE THERAPY

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

(2010) Rupesh Dash et al.   CANCER RESEARCH

mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

(2010) Rupesh Dash et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutic modulation of k-ras signaling in colorectal cancer

(2010) Lisanne L. Krens et al.   DRUG DISCOVERY TODAY

scVEGF Microbubble Ultrasound Contrast Agents

(2010) Christopher R. Anderson et al.   INVESTIGATIVE RADIOLOGY

Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus

(2010) Katsuyuki Hamada et al.   JOURNAL OF GENE MEDICINE

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

(2010) M. A. Park et al.   MOLECULAR PHARMACOLOGY

Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma

(2010) Hossein A Hamed et al.   MOLECULAR THERAPY

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression

(2010) Hyo-eun C Bhang et al.   NATURE MEDICINE

Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency

(2010) Salima Hacein-Bey-Abina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene therapy for high-grade glioma

(2010) Atsushi Natsume et al.   Cell Adhesion & Migration

Gene Therapy: The First Approved Gene-Based Medicines, Molecular Mechanisms and Clinical Indications

(2010) J. Raty et al.   Current Molecular Pharmacology

TRAIL Gene Therapy: From Preclinical Development to Clinical Application

(2009) Thomas Griffith et al.   CURRENT GENE THERAPY

Progress and prospects: immune responses to viral vectors

(2009) S Nayak et al.   GENE THERAPY

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

(2009) S. NAYAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

(2009) Albert M Maguire et al.   LANCET

Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach

(2009) Adelaide Greco et al.   MOLECULAR THERAPY

Biodistribution of TNF-α-coated gold nanoparticles in anin vivomodel system

(2009) Raghav Goel et al.   Nanomedicine

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

(2009) Erika L Abel et al.   Nature Protocols

A cancer terminator virus eradicates both primary and distant human melanomas

(2008) D Sarkar et al.   CANCER GENE THERAPY

Macrophage Depletion Combined with Anticoagulant Therapy Increases Therapeutic Window of Systemic Treatment with Oncolytic Adenovirus

(2008) E. V. Shashkova et al.   CANCER RESEARCH

Secretable Chaperone Grp170 Enhances Therapeutic Activity of a Novel Tumor Suppressor, mda-7/IL-24

(2008) P. Gao et al.   CANCER RESEARCH

Mechanism of In vitro Pancreatic Cancer Cell Growth Inhibition by Melanoma Differentiation-Associated Gene-7/Interleukin-24 and Perillyl Alcohol

(2008) I. V. Lebedeva et al.   CANCER RESEARCH

Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer

(2008) A. L. Parker et al.   JOURNAL OF VIROLOGY

Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells

(2008) M. Zheng et al.   MOLECULAR CANCER THERAPEUTICS

Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis

(2008) I. V. Lebedeva et al.   MOLECULAR CANCER THERAPEUTICS

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis

(2008) M. Sauane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Delivery of Macromolecular Drugs: Asialoglycoprotein Receptor (ASGPR) Expression by Selected Hepatoma Cell Lines used in Antiviral Drug Development

(2008) Yan Li et al.   Current Drug Delivery