Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon

Loss of aryl hydrocarbon receptor promotes colon tumorigenesis in ApcS580/+; KrasG12D/+ mice

(2021) Huajun Han et al.   MOLECULAR CANCER RESEARCH

Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis

(2020) Erika L. Garcia-Villatoro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ah receptor ligands and their impacts on gut resilience: structure–activity effects

(2020) Stephen Safe et al.   CRITICAL REVIEWS IN TOXICOLOGY

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

(2020) Samantha A. Scott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

(2019) Ludovica Marinelli et al.   Scientific Reports

Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations

(2018) Song-Yi Park et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis

(2018) Jennifer AA DeLuca et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

(2018) Ikuko Kashino et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolomic response to coffee consumption: application to a three-stage clinical trial

(2018) M. C. Cornelis et al.   JOURNAL OF INTERNAL MEDICINE

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids

(2018) Un-Ho Jin et al.   TOXICOLOGICAL SCIENCES

Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism

(2018) Erikka Loftfield et al.   JAMA Internal Medicine

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

(2018) Amina Metidji et al.   IMMUNITY

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome

(2018) Kazuchika Nishitsuji et al.   Scientific Reports

Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice

(2018) Reiji Aoki et al.   JOURNAL OF IMMUNOLOGY

Coffee and health: what we still don't know

(2018) Ahmed El-Sohemy   AMERICAN JOURNAL OF CLINICAL NUTRITION

Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals

(2018) Dong Hang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice

(2017) Jahidul Islam et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice

(2017) Syunsuke Watanabe et al.   Metabolic Syndrome and Related Disorders

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

(2017) Un-Ho Jin et al.   Scientific Reports

The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse

(2016) Carol J. Díaz-Díaz et al.   ANNALS OF SURGERY

Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies

(2016) Stefano Marventano et al.   CLINICAL NUTRITION

Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation ofSocs3Gene Expression

(2016) Taira Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure–Activity Relationships and Receptor Modeling

(2016) Yating Cheng et al.   TOXICOLOGICAL SCIENCES

Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies

(2016) Yong Gan et al.   Oncotarget

Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism

(2016) Agata Korecka et al.   npj Biofilms and Microbiomes

Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective CohortsClinical Perspective

(2015) Ming Ding et al.   CIRCULATION

Coffee Consumption and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Dose-Response Meta-Analysis

(2014) Alessio Crippa et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific

(2014) Siew C Ng et al.   GUT

Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics

(2014) Theresa E. Cowan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Induction of AhR-Mediated Gene Transcription by Coffee

(2014) Toshio Ishikawa et al.   PLoS One

Long-Term Coffee Consumption and Risk of Cardiovascular Disease

(2013) Ming Ding et al.   CIRCULATION

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Association of Coffee Drinking with Total and Cause-Specific Mortality

(2012) Neal D. Freedman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Impact of coffee consumption on the gut microbiota: A human volunteer study

(2009) Muriel Jaquet et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

(2009) K. Kawajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice

(2008) Q. Jia et al.   CANCER RESEARCH