The challenging world of extracellular RNAs of helminth parasites

Extracellular tRNAs and tRNA-derived fragments

(2020) Juan Pablo Tosar et al.   RNA Biology

The insufficiency of circulating miRNA and DNA as diagnostic tools or as biomarkers of treatment efficacy for Onchocerca volvulus

(2020) Cara L. Macfarlane et al.   Scientific Reports

The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities

(2020) Javier Sotillo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Extracellular vesicles from Heligmosomoides bakeri and Trichuris muris contain distinct microRNA families and small RNAs that could underpin different functions in the host

(2020) Ruby White et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression

(2020) Peter J. Taylor et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Characterization of exosome-like vesicles derived from Taenia pisiformis cysticercus and their immunoregulatory role on macrophages

(2020) Li-Qun Wang et al.   Parasites & Vectors

Comprehensive Analysis of Non-coding RNA Profiles of Exosome-Like Vesicles From the Protoscoleces and Hydatid Cyst Fluid of Echinococcus granulosus

(2020) Xiaofan Zhang et al.   Frontiers in Cellular and Infection Microbiology

Extracellular Vesicles Derived From Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice

(2020) Yong Yang et al.   Frontiers in Immunology

Proteomic and deep sequencing analysis of extracellular vesicles isolated from adult male and female Schistosoma japonicum

(2020) Pengfei Du et al.   PLoS Neglected Tropical Diseases

Extracellular non-coding RNA signatures of the metacestode stage of Echinococcus multilocularis

(2020) María Eugenia Ancarola et al.   PLoS Neglected Tropical Diseases

Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides

(2019) Franklin Wang-Ngai Chow et al.   NUCLEIC ACIDS RESEARCH

Identification and molecular characterization of exosome-like vesicles derived from the Taenia asiatica adult worm

(2019) Panhong Liang et al.   ACTA TROPICA

Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism

(2019) Juntao Liu et al.   PLoS Pathogens

Profiling circulating microRNAs in serum of Fasciola gigantica-infected buffalo

(2019) Xiaola Guo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Revisiting the Phylogenetic History of Helminths Through Genomics, the Case of the New Echinococcus oligarthrus Genome

(2019) Lucas L. Maldonado et al.   Frontiers in Genetics

Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development

(2019) Neil D. Marks et al.   Scientific Reports

Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo

(2019) Juan F. Quintana et al.   PLoS Neglected Tropical Diseases

miRNA-seq of Echinococcus multilocularis Extracellular Vesicles and Immunomodulatory Effects of miR-4989

(2019) Juntao Ding et al.   Frontiers in Microbiology

Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up

(2019) Zahra Alizadeh et al.   ACTA TROPICA

Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection

(2019) Bikash Ranjan Giri et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Disentangling sRNA-Seq data to study RNA communication between species

(2019) José Roberto Bermúdez-Barrientos et al.   NUCLEIC ACIDS RESEARCH

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

(2019) Yi Mu et al.   PARASITOLOGY

Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro

(2019) Matías Gastón Pérez et al.   PLoS Neglected Tropical Diseases

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs

(2018) Juan Pablo Tosar et al.   NUCLEIC ACIDS RESEARCH

Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

(2018) Vitalie Samoil et al.   Scientific Reports

Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice

(2018) Ramon M. Eichenberger et al.   Frontiers in Immunology

Further Characterization of Molecular Markers in Canine Dirofilaria immitis Infection

(2018) Ashley Behan-Braman et al.   JOURNAL OF PARASITOLOGY

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

(2018) Helena Sork et al.   Scientific Reports

Small non-coding RNA landscape of extracellular vesicles from human stem cells

(2018) Sippy Kaur et al.   Scientific Reports

Comparative genomics of the major parasitic worms

(2018)   NATURE GENETICS

Excretory/secretory products from the gastrointestinal nematode Trichuris muris

(2017) Lucienne Tritten et al.   EXPERIMENTAL PARASITOLOGY

Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo

(2017) María Eugenia Ancarola et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Expression profiling of circulating miRNAs in mouse serum in response to Echinococcus multilocularis infection

(2017) XIAOLA GUO et al.   PARASITOLOGY

Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR

(2017) Ole Lagatie et al.   PARASITOLOGY RESEARCH

tRNA-derived small RNAs: New players in genome protection against retrotransposons

(2017) German Martinez   RNA Biology

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus

(2017) Henry Y. Gu et al.   PLoS Neglected Tropical Diseases

Recent progress toward the use of circulating microRNAs as clinical biomarkers

(2016) Vikas Ghai et al.   ARCHIVES OF TOXICOLOGY

MicroRNA discovery in the human parasite Echinococcus multilocularis from genome-wide data

(2016) L. Kamenetzky et al.   GENOMICS

Release of extracellular vesicles containing small RNAs from the eggs of Schistosoma japonicum

(2016) Shanli Zhu et al.   Parasites & Vectors

MicroRNAs in Parasitic Helminthiases: Current Status and Future Perspectives

(2016) Pengfei Cai et al.   TRENDS IN PARASITOLOGY

Molecular characterization of S. japonicum exosome-like vesicles reveals their regulatory roles in parasite-host interactions

(2016) Lihui Zhu et al.   Scientific Reports

MicroRNAs Are Involved in the Regulation of Ovary Development in the Pathogenic Blood Fluke Schistosoma japonicum

(2016) Lihui Zhu et al.   PLoS Pathogens

The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles

(2015) B. Fromm et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Functional roles of non-coding Y RNAs

(2015) Madzia P. Kowalski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Non-coding stem-bulge RNAs are required for cell proliferation and embryonic development in C. elegans

(2015) M. P. Kowalski et al.   JOURNAL OF CELL SCIENCE

Secretion of RNA-Containing Extracellular Vesicles by the Porcine Whipworm,Trichuris suis

(2015) Eline Palm Hansen et al.   JOURNAL OF PARASITOLOGY

Extracellular Onchocerca-derived small RNAs in host nodules and blood

(2015) Juan F Quintana et al.   Parasites & Vectors

Application of small RNA technology for improved control of parasitic helminths

(2015) Collette Britton et al.   VETERINARY PARASITOLOGY

Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages

(2015) Peter Sarkies et al.   PLOS BIOLOGY

Circulating miRNAs: Potential Novel Biomarkers for Hepatopathology Progression and Diagnosis of Schistosomiasis Japonica in Two Murine Models

(2015) Pengfei Cai et al.   PLoS Neglected Tropical Diseases

Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi

(2015) Mostafa Zamanian et al.   PLoS Neglected Tropical Diseases

C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

(2014) Juan Wang et al.   CURRENT BIOLOGY

Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs

(2014) Dolores Bernal et al.   Journal of Proteomics

Loa loa and Onchocerca ochengi miRNAs detected in host circulation

(2014) Lucienne Tritten et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Serum aca-mir-146a is a potential biomarker for early diagnosis of Angiostrongylus cantonensis infection

(2014) Xiaoguang Chen et al.   PARASITOLOGY RESEARCH

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

(2014) Amy H. Buck et al.   Nature Communications

Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection

(2014) Anna M. Hoy et al.   PLoS Neglected Tropical Diseases

Detection of Circulating Parasite-Derived MicroRNAs in Filarial Infections

(2014) Lucienne Tritten et al.   PLoS Neglected Tropical Diseases

Biases in small RNA deep sequencing data

(2013) Carsten A. Raabe et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum

(2013) GUOFENG CHENG et al.   PARASITOLOGY

Slicing tRNAs to boost functional ncRNA diversity

(2013) Jennifer Gebetsberger et al.   RNA Biology

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmes

(2012) James S. McCarthy et al.   PLoS Neglected Tropical Diseases

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The miR-10 microRNA precursor family

(2011) Disa Tehler et al.   RNA Biology

Nematode sbRNAs: Homologs of Vertebrate Y RNAs

(2010) Ilenia Boria et al.   JOURNAL OF MOLECULAR EVOLUTION

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY