Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

(2019) Cassandra Terry et al.   Scientific Reports

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

(2019) Falk Liberta et al.   Nature Communications

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Protein-Solvent Interfaces in Human Y145Stop Prion Protein Amyloid Fibrils Probed by Paramagnetic Solid-State NMR Spectroscopy

(2018) Darryl Aucoin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp

(2018) Marcus Gallagher-Jones et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp

(2018) Marcus Gallagher-Jones et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease

(2018) Zhen Zheng et al.   Scientific Reports

Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions

(2018) Qiuye Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy

(2018) Theint Theint et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

High-throughput screening and scale-up of cocrystals using resonant acoustic mixing

(2017) Karthik Nagapudi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

A bacterial global regulator forms a prion

(2017) Andy H. Yuan et al.   SCIENCE

Toward the Atomic Structure of PrP Sc

(2017) Jose A. Rodriguez et al.   Cold Spring Harbor Perspectives in Biology

Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy

(2017) Theint Theint et al.   Nature Communications

Prion strains in mammals: Different conformations leading to disease

(2017) Rodrigo Morales   PLoS Pathogens

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Amyloid fibrils from the N-terminal prion protein fragment are infectious

(2016) Jin-Kyu Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex vivomammalian prions are formed of paired double helical prion protein fibrils

(2016) Cassandra Terry et al.   Open Biology

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

Structural Studies of Truncated Forms of the Prion Protein PrP

(2015) William Wan et al.   BIOPHYSICAL JOURNAL

A naturally occurring variant of the human prion protein completely prevents prion disease

(2015) Emmanuel A. Asante et al.   NATURE

De novo generation of infectious prions with bacterially expressed recombinant prion protein

(2013) Zhihong Zhang et al.   FASEB JOURNAL

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Inherited Prion Disease A117V Is Not Simply a Proteinopathy but Produces Prions Transmissible to Transgenic Mice Expressing Homologous Prion Protein

(2013) Emmanuel A. Asante et al.   PLoS Pathogens

High-resolution structure of infectious prion protein: the final frontier

(2012) Rodrigo Diaz-Espinoza et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The hydrophobic core region governs mutant prion protein aggregation and intracellular retention

(2010) Emiliano Biasini et al.   BIOCHEMICAL JOURNAL

PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta

(2010) S. Chaudhury et al.   BIOINFORMATICS

Prion Diseases and Their Biochemical Mechanisms†

(2009) Nathan J. Cobb et al.   BIOCHEMISTRY

Natural and synthetic prion structure from X-ray fiber diffraction

(2009) H. Wille et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Structure of Amyloid Fibrils Formed by Residues 106–126 of the Human Prion Protein

(2009) Patrick Walsh et al.   STRUCTURE

Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils

(2008) Valerie L. Sim et al.   NEUROBIOLOGY OF AGING

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE