Blood mitochondrial DNA copy number: What are we counting?

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

(2021) Stephanie Y Yang et al.   GENOME RESEARCH

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

(2021) Rohit Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations

(2021) Caroline Trumpff et al.   MITOCHONDRION

An atlas of mitochondrial DNA genotype–phenotype associations in the UK Biobank

(2021) Ekaterina Yonova-Doing et al.   NATURE GENETICS

An energetics perspective on geroscience: mitochondrial protonmotive force and aging

(2021) Brandon J. Berry et al.   GeroScience

Mitochondrial DNA: cellular genotoxic stress sentinel

(2021) Zheng Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Blood contains circulating cell‐free respiratory competent mitochondria

(2020) Zahra Al Amir Dache et al.   FASEB JOURNAL

Platelet mtDNA content and leukocyte count influence whole blood mtDNA content

(2020) Hanjoo B. Shim et al.   MITOCHONDRION

A mitochondrial root to accelerated ageing and frailty

(2020) Luigi Ferrucci et al.   Nature Reviews Endocrinology

Evaluation of mitochondrial DNA copy number estimation techniques

(2020) Ryan J. Longchamps et al.   PLoS One

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

A case for measuring both cellular and cell‐free mitochondrial DNA as a disease biomarker in human blood

(2020) Hannah S. Rosa et al.   FASEB JOURNAL

Characterization and origins of cell-free mitochondria in healthy murine and human blood

(2020) Olivia R. Stephens et al.   MITOCHONDRION

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma

(2020) Sarah A Ware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells

(2020) Anja M. Gumpp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs

(2020) Kelsey L. McLaughlin et al.   Scientific Reports

Control of Leukocyte Trafficking by Stress-Associated Hormones

(2019) Louise M. Ince et al.   Frontiers in Immunology

Acute psychological stress increases serum circulating cell-free mitochondrial DNA

(2019) Caroline Trumpff et al.   PSYCHONEUROENDOCRINOLOGY

Forms of extracellular mitochondria and their impact in health

(2019) Sophia Miliotis et al.   MITOCHONDRION

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution

(2019) Ryan O'Hara et al.   GENOME RESEARCH

Mitochondrial psychobiology: foundations and applications

(2019) Martin Picard et al.   Current Opinion in Behavioral Sciences

Mitochondrial DNA Depletion Syndromes

(2019) Donald Basel   CLINICS IN PERINATOLOGY

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Sub-cellular origin of mtDNA deletions in human skeletal muscle

(2018) Amy E Vincent et al.   ANNALS OF NEUROLOGY

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress

(2018) Martin Picard et al.   BIOLOGICAL PSYCHIATRY

Current knowledge on the acute regulation of steroidogenesis†

(2018) Vimal Selvaraj et al.   BIOLOGY OF REPRODUCTION

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

(2018) Etienne Patin et al.   NATURE IMMUNOLOGY

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

(2018) Daniel Lindqvist et al.   NEUROPSYCHOPHARMACOLOGY

Mitochondrial Toxicity

(2018) Joel N Meyer et al.   TOXICOLOGICAL SCIENCES

Quantitation of the cellular content of saliva and buccal swab samples

(2018) Christiane Theda et al.   Scientific Reports

Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment

(2018) Parvin Kumar et al.   Scientific Reports

Plasmid-normalized quantification of relative mitochondrial DNA copy number

(2018) Federica Fazzini et al.   Scientific Reports

Cell-free DNA release under psychosocial and physical stress conditions

(2018) E. M. Hummel et al.   Translational Psychiatry

Child's buccal cell mitochondrial DNA content modifies the association between heart rate variability and recent air pollution exposure at school

(2018) Nelly D. Saenen et al.   ENVIRONMENT INTERNATIONAL

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study

(2017) J E Verhoeven et al.   MOLECULAR PSYCHIATRY

Intraindividual variability in cortisol: Approaches, illustrations, and recommendations

(2017) Suzanne C. Segerstrom et al.   PSYCHONEUROENDOCRINOLOGY

Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants

(2017) Deborah A. Roubicek et al.   TOXICOLOGY

Discovery of rare, diagnostic AluYb8/9 elements in diverse human populations

(2017) Julie Feusier et al.   Mobile DNA

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

(2017) Foram N. Ashar et al.   JAMA Cardiology

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

(2016) Audrey R. Tyrka et al.   BIOLOGICAL PSYCHIATRY

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts

(2016) Yamilee Hurtado-Roca et al.   PLoS One

Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women

(2016) Shasha Meng et al.   Oncotarget

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

(2016) Manja Wachsmuth et al.   PLoS Genetics

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

Molecular Signatures of Major Depression

(2015) Na Cai et al.   CURRENT BIOLOGY

Generation of Rho Zero Cells: Visualization and Quantification of the mtDNA Depletion Process

(2015) Susanna Schubert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cigarette toxicity triggers Leber’s hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

(2015) L Giordano et al.   Cell Death & Disease

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

(2015) Masataka Ikeda et al.   PLoS One

Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism

(2014) Roberto Vettor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial DNA Copy Number and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Risk in Two Prospective Studies

(2014) C. Kim et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

(2014) K. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

(2014) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

(2013) Carla Giordano et al.   BRAIN

Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data

(2013) Ginevra Biino et al.   PLoS One

Time Course Analysis Reveals Gene-Specific Transcript and Protein Kinetics of Adaptation to Short-Term Aerobic Exercise Training in Human Skeletal Muscle

(2013) Brendan Egan et al.   PLoS One

Mitochondrial Dysfunction and Lipid Accumulation in the Human Diaphragm during Mechanical Ventilation

(2012) Martin Picard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

(2012) Richard D. W. Kelly et al.   NUCLEIC ACIDS RESEARCH

Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones – Curt Richter Award Winner

(2012) Firdaus S. Dhabhar et al.   PSYCHONEUROENDOCRINOLOGY

Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias

(2011) Afshan N. Malik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of sleep and circadian rhythm on the human immune system

(2010) Tanja Lange et al.   Annals of the New York Academy of Sciences

Regional variation in mitochondrial DNA copy number in mouse brain

(2010) Satoshi Fuke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules

(2010) Patrick Yu-Wai-Man et al.   HUMAN MOLECULAR GENETICS

High mitochondrial DNA copy number has detrimental effects in mice

(2010) Emil Ylikallio et al.   HUMAN MOLECULAR GENETICS

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Regionalized Pathology Correlates with Augmentation of mtDNA Copy Numbers in a Patient with Myoclonic Epilepsy with Ragged-Red Fibers (MERRF-Syndrome)

(2010) Anja Brinckmann et al.   PLoS One

Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD

(2010) L. Puente-Maestu et al.   THORAX

DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination

(2009) Wen Guo et al.   MITOCHONDRION

Platelet contamination causes large variation as well as overestimation of mitochondrial DNA content of peripheral blood mononuclear cells

(2008) M. Urata et al.   ANNALS OF CLINICAL BIOCHEMISTRY