Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

Genome-wide association studies suggest that APOL1 -environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1 –second gene interactions

(2018) Carl D. Langefeld et al.   KIDNEY INTERNATIONAL

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Kidney Disease Among African Americans: A Population Perspective

(2018) Marciana Laster et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

(2017) Vijay K. Gonugunta et al.   Cell Reports

Editorial: Podocytes as Active Participants in Lupus Nephritis

(2017) Ian R. Rifkin et al.   Arthritis & Rheumatology

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

(2017) Jie An et al.   Arthritis & Rheumatology

Social Determinants of Racial Disparities in CKD

(2016) J. M. Norton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advances in the treatment of cutaneous lupus erythematosus

(2016) A Kuhn et al.   LUPUS

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

(2015) Atanu K. Khatua et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects

(2015) M. G. Sampson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

(2015) Chandra Mohan et al.   Nature Reviews Nephrology

The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling

(2014) Qian Zhou et al.   Cell Host & Microbe

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Podocyte involvement in lupus nephritis based on the 2003 ISN/RPS system: a large cohort study from a single centre

(2014) Yan Wang et al.   RHEUMATOLOGY

The Antiviral Cytokines IFN-α and IFN-β Modulate Parietal Epithelial Cells and Promote Podocyte Loss

(2013) Adriana Migliorini et al.   AMERICAN JOURNAL OF PATHOLOGY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

(2013) Takayuki Abe et al.   MOLECULAR CELL

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy

(2013) S. R. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

Type I IFN system in the development and manifestations of SLE

(2012) Keith B. Elkon et al.   CURRENT OPINION IN RHEUMATOLOGY

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts

(2011) X. Duan et al.   MOLECULAR CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

(2010) H. Machida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR

(2009) I Kimkong et al.   LUPUS

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Role of podocytes in lupus nephritis

(2009) S. Trivedi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lupus Nephritis

(2008) Elin S. Mortensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

(2008) Divaker Choubey et al.   IMMUNOLOGY LETTERS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE