Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo

Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication

(2019) Jacqueline K. Barton et al.   Annual Review of Biochemistry

Principles for Integrative Structural Biology Studies

(2019) Michael P. Rout et al.   CELL

Structure and Function of Multimeric G-Quadruplexes

(2019) Sofia Kolesnikova et al.   MOLECULES

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

(2018) Pol Margalef et al.   CELL

Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension

(2018) Rosa M Porreca et al.   NUCLEIC ACIDS RESEARCH

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

(2018) Niek van Wietmarschen et al.   Nature Communications

DNA translocation mechanism of an XPD family helicase

(2018) Kaiying Cheng et al.   eLife

Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs

(2017) Ashley D Sanders et al.   Nature Protocols

Self-biotinylation of DNA G-quadruplexes via intrinsic peroxidase activity

(2017) Owen J. Einarson et al.   NUCLEIC ACIDS RESEARCH

Bromodeoxyuridine does not contribute to sister chromatid exchange events in normal or Bloom syndrome cells

(2016) Niek van Wietmarschen et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase

(2015) Xi-Miao Hou et al.   BIOCHEMICAL JOURNAL

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription

(2015) John A. Smestad et al.   BMC Medical Genetics

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

(2015) Charikleia Papadopoulou et al.   Cell Reports

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

(2014) Jagat B. Budhathoki et al.   NUCLEIC ACIDS RESEARCH

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia

(2014) Robert M. Brosh et al.   Frontiers in Genetics

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

(2013) Rebekka A. Schwab et al.   JOURNAL OF CELL BIOLOGY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Assessing the Amount of Quadruplex Structures Present within G2-Tract Synthetic Random-Sequence DNA Libraries

(2013) Simon A. McManus et al.   PLoS One

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal–Hreidarsson syndrome

(2013) Zhong Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

The Mammalian Proteins MMS19, MIP18, and ANT2 Are Involved in Cytoplasmic Iron-Sulfur Cluster Protein Assembly

(2012) Niek van Wietmarschen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RTEL1 contributes to DNA replication and repair and telomere maintenance

(2012) Evert-Jan Uringa et al.   MOLECULAR BIOLOGY OF THE CELL

Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription

(2012) Patrick M. Grierson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution

(2012) Ester Falconer et al.   NATURE METHODS

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

(2012) K. Gari et al.   SCIENCE

Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes

(2012) Geraldine Aubert et al.   PLoS Genetics

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

(2011) Nuno M. V. Gomes et al.   AGING CELL

Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells

(2011) S. Sekulovic et al.   BLOOD

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

(2011) Avvaru N Suhasini et al.   EMBO JOURNAL

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

(2011) Patrick M. Grierson et al.   HUMAN MOLECULAR GENETICS

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

G-Quadruplex Hinders Translocation of BLM Helicase on DNA: A Real-Time Fluorescence Spectroscopic Unwinding Study and Comparison with Duplex Substrates

(2010) Jia-quan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

In the Beginning Was the Worm ...

(2009) S. Brenner   GENETICS

Identification of sister chromatids by DNA template strand sequences

(2009) Ester Falconer et al.   NATURE

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Telomeres, stem cells, and hematology

(2008) P. M. Lansdorp   BLOOD

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY