Structure and Function of Multimeric G-Quadruplexes

G-quadruplex–forming GGA repeat region functions as a negative regulator of the Ccnb1ip1 enhancer

(2019) Izzul Islam et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Interplay of Three G-Quadruplex Units in the KIT Promoter

(2019) Cosimo Ducani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conserved G-Quadruplexes Regulate the Immediate Early Promoters of Human Alphaherpesviruses

(2019) Ilaria Frasson et al.   MOLECULES

GTP-Dependent Formation of Multimeric G-Quadruplexes

(2019) Sofia Kolesnikova et al.   ACS Chemical Biology

Sequence Requirements of Intrinsically Fluorescent G-Quadruplexes

(2018) Tat’ána Majerová et al.   BIOCHEMISTRY

Ligand-Induced Dimerization of a Truncated Parallel MYC G-Quadruplex

(2018) Andrea Funke et al.   CHEMBIOCHEM

Long repeating (TTAGGG)nsingle-stranded DNA self-condenses into compact beaded filaments stabilized by G-quadruplex formation

(2018) Anirban Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution AFM structure of DNA G-wires in aqueous solution

(2018) Krishnashish Bose et al.   Nature Communications

Monomolecular tetrahelix of polyguanine with a strictly defined folding pattern

(2018) Besik Kankia   Scientific Reports

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

(2018) Enrico Lavezzo et al.   PLoS Computational Biology

Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

(2017) Dhurjhoti Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution three-dimensional NMR structure of theKRASproto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

(2017) Abdelaziz Kerkour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for high-affinity fluorophore binding and activation by RNA Mango

(2017) Robert J Trachman et al.   Nature Chemical Biology

Multimerization rules for G-quadruplexes

(2017) Sofia Kolesnikova et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of a new G-quadruplex forming region within the kRAS promoter as a transcriptional regulator

(2016) Rhianna K. Morgan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

(2016) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

(2016) Ming-Hao Hu et al.   NUCLEIC ACIDS RESEARCH

Altered biochemical specificity of G-quadruplexes with mutated tetrads

(2016) Kateřina Švehlová et al.   NUCLEIC ACIDS RESEARCH

An intermolecular G-quadruplex as the basis for GTP recognition in the class V–GTP aptamer

(2016) Amir H. Nasiri et al.   RNA

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

Tetraphenylethene Derivatives with Different Numbers of Positively Charged Side Arms have Different Multimeric G-Quadruplex Recognition Specificity

(2015) Qi Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

KRASpromoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units

(2015) Peter Podbevšek et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

(2015) Aaron L. Moye et al.   Nature Communications

“Nano-oddities”: Unusual Nucleic Acid Assemblies for DNA-Based Nanostructures and Nanodevices

(2014) Liliya A. Yatsunyk et al.   ACCOUNTS OF CHEMICAL RESEARCH

Formation of DNA:RNA Hybrid G-Quadruplexes of Two G-Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G-Quadruplexes in Genomes

(2014) Shan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

i-Motif DNA: Structure, stability and targeting with ligands

(2014) Henry A. Day et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Programmed Self-Assembly of a Quadruplex DNA Nanowire

(2014) Nason Ma'ani Hessari et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Tetrahelical Monomolecular Architecture of DNA: A New Building Block for Nanotechnology

(2014) Besik Kankia   JOURNAL OF PHYSICAL CHEMISTRY B

Structure and Conformational Dynamics of a Stacked Dimeric G-Quadruplex Formed by the Human CEB1 Minisatellite

(2014) Michael Adrian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA

(2014) Jia-yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore

(2014) Hao Huang et al.   Nature Chemical Biology

Nascent RNA transcripts facilitate the formation of G-quadruplexes

(2014) Prakash Shrestha et al.   NUCLEIC ACIDS RESEARCH

A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site

(2014) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes

(2014) Xiao-Xi Huang et al.   NUCLEIC ACIDS RESEARCH

An Improved Model for the hTERT Promoter Quadruplex

(2014) Jonathan B. Chaires et al.   PLoS One

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes

(2013) Valentina D'Atri et al.   BIOCHIMIE

Discovery of Widespread GTP-Binding Motifs in Genomic DNA and RNA

(2013) Edward A. Curtis et al.   CHEMISTRY & BIOLOGY

Crystal Structure of a Promoter Sequence in the B-raf Gene Reveals an Intertwined Dimer Quadruplex

(2013) Dengguo Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site

(2013) Chuanqi Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Study on effects of molecular crowding on G-quadruplex-ligand binding and ligand-mediated telomerase inhibition

(2013) Hidenobu Yaku et al.   METHODS

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals

(2013) Shan Xiao et al.   NUCLEIC ACIDS RESEARCH

Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control

(2013) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures are stable and detectable in human genomic DNA

(2013) Enid Yi Ni Lam et al.   Nature Communications

Structural Investigations on the Anti-HIV G-Quadruplex-Forming Oligonucleotide TGGGAG and Its Analogues: Evidence for the Presence of an A-Tetrad

(2012) Antonella Virgilio et al.   CHEMBIOCHEM

Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene

(2012) Marko Trajkovski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Guanine base stacking in G-quadruplex nucleic acids

(2012) Christopher Jacques Lech et al.   NUCLEIC ACIDS RESEARCH

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes

(2012) Vitaly Kuryavyi et al.   STRUCTURE

Transcription Arrest by a G Quadruplex Forming-Trinucleotide Repeat Sequence from the Human c-myb Gene

(2011) Christopher Broxson et al.   BIOCHEMISTRY

A structural analysis of G-quadruplex/ligand interactions

(2011) Shozeb M. Haider et al.   BIOCHIMIE

Structure and Stability of Higher-Order Human Telomeric Quadruplexes

(2011) Luigi Petraccone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity†

(2011) Ngoc Quang Do et al.   NUCLEIC ACIDS RESEARCH

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads

(2011) Nicola Borbone et al.   NUCLEIC ACIDS RESEARCH

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability

(2011) Raveendra I. Mathad et al.   NUCLEIC ACIDS RESEARCH

Self-organization of G-quadruplex structures in the hTERT core promoter stabilized by polyaminic side chain perylene derivatives

(2010) Emanuela Micheli et al.   BIOPHYSICAL CHEMISTRY

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements

(2010) Samantha Kendrick et al.   PURE AND APPLIED CHEMISTRY

Consecutive Formation of G-Quadruplexes in Human Telomeric-Overhang DNA: A Protective Capping Structure for Telomere Ends

(2009) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The c-MYC NHE III1: Function and Regulation

(2009) Verónica González et al.   Annual Review of Pharmacology and Toxicology

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Dynamics and Principal Components Analysis of Human Telomeric Quadruplex Multimers

(2008) Shozeb Haider et al.   BIOPHYSICAL JOURNAL

Ligand Binding to Tandem G Quadruplexes from Human Telomeric DNA

(2008) Li-Ping Bai et al.   CHEMBIOCHEM

The Tail of the Telomere

(2008) Luigi Petraccone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation†

(2008) Nicolas Smargiasso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH

Choose your partners: dimerization in eukaryotic transcription factors

(2008) Grigoris D. Amoutzias et al.   TRENDS IN BIOCHEMICAL SCIENCES

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY