Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex

Side Chain Hydrogen-Bonding Interactions within Amyloid-like Fibrils Formed by the Low-Complexity Domain of FUS: Evidence from Solid State Nuclear Magnetic Resonance Spectroscopy

(2020) Dylan T. Murray et al.   BIOCHEMISTRY

Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin

(2020) Liang Wang et al.   CELL RESEARCH

Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by tuning the Electronic Structure of Dioxo Ligands

(2020) Anna Notaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids

(2020) Ahtasham Raza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Weak interactions in higher-order chromatin organization

(2020) Omar L Kantidze et al.   NUCLEIC ACIDS RESEARCH

Par complex cluster formation mediated by phase separation

(2020) Ziheng Liu et al.   Nature Communications

Nuclear microenvironment in cancer: Control through liquid‐liquid phase separation

(2020) Ryu‐Suke Nozawa et al.   CANCER SCIENCE

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies

(2020) Woonyung Hur et al.   DEVELOPMENTAL CELL

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

(2020) Hong Zhang et al.   Science China-Life Sciences

Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy

(2020) Johannes Karges et al.   Nature Communications

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

(2020) Guangya Zhu et al.   CELL

Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

(2020) Hilmar Strickfaden et al.   CELL

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

Targeting liquid-liquid phase separation in pancreatic cancer

(2019) Yue Ming et al.   Translational Cancer Research

A “Dual-key-and-lock” Ruthenium Complex Probe for Lysosomal Formaldehyde in Cancer Cells and Tumors

(2019) Liu Chaolong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications

(2019) Justin Shum et al.   INORGANIC CHEMISTRY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Structural studies reveal the enantiospecific recognition of a DNA G-quadruplex by a ruthenium polypyridyl complex

(2019) Kane McQuaid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility

(2019) Roni H.G. Wright et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genome organization around nuclear speckles

(2019) Yu Chen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Photoswitchable Phase Separation and Oligonucleotide Trafficking in DNA Coacervate Microdroplets

(2019) Nicolas Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

HP1 reshapes nucleosome core to promote phase separation of heterochromatin

(2019) S. Sanulli et al.   NATURE

Highly Selective Mitochondrial Targeting by a Ruthenium(II) Peptide Conjugate: Imaging and Photoinduced Damage of Mitochondrial DNA

(2018) Tia E. Keyes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ubiquitin-induced phase separation of p62/SQSTM1

(2018) Lina Herhaus et al.   CELL RESEARCH

A Transient Rise in Free Mg 2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation

(2018) Kazuhiro Maeshima et al.   CURRENT BIOLOGY

A User’s Guide for Phase Separation Assays with Purified Proteins

(2018) Simon Alberti et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting Photoinduced DNA Destruction by Ru(II) Tetraazaphenanthrene in Live Cells by Signal Peptide

(2018) Christopher S. Burke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

(2018) Feng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

(2018) Feng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

(2018) Menglong Zeng et al.   CELL

mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation

(2018) Gangming Zhang et al.   CELL

X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes

(2018) Kane McQuaid et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing

(2018) Iain A. Sawyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

(2018) Yongdae Shin et al.   CELL

Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation

(2018) Shuai Zhao et al.   CELL RESEARCH

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

Quaternary Phosphorus-Induced Iodocuprate(I)-Based Hybrids: Water Stabilities, Tunable Luminescence and Photocurrent Responses

(2018) Wen-Ting Zhang et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells

(2018) Doris Berchtold et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes

(2017) Jian-Jun Cao et al.   Chemical Science

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Mechanisms and Consequences of Macromolecular Phase Separation

(2016) Louis-Philippe Bergeron-Sandoval et al.   CELL

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

(2016) Enzo Alessio   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Activation of transcription enforces the formation of distinct nuclear bodies in zebrafish embryos

(2016) Patricia Heyn et al.   RNA Biology

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

An efficient route to asymmetrically diconjugated tris(heteroleptic) complexes of Ru(ii)

(2016) Christopher S. Burke et al.   RSC Advances

Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy

(2015) Huaiyi Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dinuclear Ruthenium(II) Complexes as Two-Photon, Time-Resolved Emission Microscopy Probes for Cellular DNA

(2014) Elizabeth Baggaley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

(2014) Cristina Mari et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peptide-Bridged Dinuclear Ru(II) Complex for Mitochondrial Targeted Monitoring of Dynamic Changes to Oxygen Concentration and ROS Generation in Live Mammalian Cells

(2014) Aaron Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome Architecture: Domain Organization of Interphase Chromosomes

(2013) Wendy A. Bickmore et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

(2012) Martin R. Gill et al.   CHEMICAL SOCIETY REVIEWS

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

(2010) Daniel P. Silver et al.   JOURNAL OF CLINICAL ONCOLOGY

A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells

(2009) Martin R. Gill et al.   Nature Chemistry

Morphology and Phase Separation of Hydrophobic Clusters of Soy Globular Protein Polymers

(2007) Xiuzhi Susan Sun et al.   MACROMOLECULAR BIOSCIENCE