HP1 reshapes nucleosome core to promote phase separation of heterochromatin

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h

(2018) Nathan Gamarra et al.   eLife

A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase

(2018) Caitlin I. Stoddard et al.   MOLECULAR CELL

Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo

(2018) Shujun Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1

(2017) Yanli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2

(2017) R. Stefan Isaac et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler

(2017) Kalyan K. Sinha et al.   SCIENCE

Nucleosomal arrays self‐assemble into supramolecular globular structures lacking 30‐nm fibers

(2016) Kazuhiro Maeshima et al.   EMBO JOURNAL

Multivalency governs HP1α association dynamics with the silent chromatin state

(2015) Sinan Kilic et al.   Nature Communications

Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR

(2014) Rina Rosenzweig et al.   Annual Review of Biochemistry

Human Heterochromatin Protein 1α Promotes Nucleosome Associations That Drive Chromatin Condensation

(2014) Abdelhamid M. Azzaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Residual Structure in Intrinsically Disordered Proteins at Residue Resolution Using Millisecond Hydrogen/Deuterium Exchange and Residue Averaging

(2014) Theodore R. Keppel et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

HP1a: a structural chromosomal protein regulating transcription

(2014) Joel C. Eissenberg et al.   TRENDS IN GENETICS

The role of the nucleosome acidic patch in modulating higher order chromatin structure

(2013) A. A. Kalashnikova et al.   Journal of the Royal Society Interface

Matching Cross-linked Peptide Spectra: Only as Good as the Worse Identification

(2013) Michael J. Trnka et al.   MOLECULAR & CELLULAR PROTEOMICS

A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

(2013) Daniele Canzio et al.   NATURE

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin

(2013) Ozan Aygün et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the histone H1-nucleosome complex

(2013) B.-R. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hinge and Chromoshadow of HP1α Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes

(2012) Yuichi Mishima et al.   JOURNAL OF MOLECULAR BIOLOGY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Role of Swi6/HP1 Self-association-mediated Recruitment of Clr4/Suv39 in Establishment and Maintenance of Heterochromatin in Fission Yeast

(2011) Swati Haldar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromodomain-Mediated Oligomerization of HP1 Suggests a Nucleosome-Bridging Mechanism for Heterochromatin Assembly

(2011) Daniele Canzio et al.   MOLECULAR CELL

Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR

(2011) H. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Living without 30nm chromatin fibers

(2010) Eden Fussner et al.   TRENDS IN BIOCHEMICAL SCIENCES

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression

(2009) Marc Lavigne et al.   PLoS Genetics