Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus

(2020) Thomas Cremer et al.   BIOESSAYS

Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin

(2020) Liang Wang et al.   CELL RESEARCH

Phase-separation in chromatin organization

(2020) Geeta J Narlikar   JOURNAL OF BIOSCIENCES

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

(2020) Fabian Erdel et al.   MOLECULAR CELL

Hyperosmotic stress: in situ chromatin phase separation

(2020) Ada L. Olins et al.   Nucleus

Fluid-like chromatin: Toward understanding the real chromatin organization present in the cell

(2020) Kazuhiro Maeshima et al.   CURRENT OPINION IN CELL BIOLOGY

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

(2019) Jason Otterstrom et al.   NUCLEIC ACIDS RESEARCH

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

(2019) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

(2019) Liang Wang et al.   MOLECULAR CELL

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

HP1 reshapes nucleosome core to promote phase separation of heterochromatin

(2019) S. Sanulli et al.   NATURE

Formation of Chromatin Subcompartments by Phase Separation

(2018) Fabian Erdel et al.   BIOPHYSICAL JOURNAL

Correlative live and super-resolution imaging reveals the dynamic structure of replication domains

(2018) Wanqing Xiang et al.   JOURNAL OF CELL BIOLOGY

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome–nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity

(2017) Yuta Shimamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging

(2017) Tadasu Nozaki et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells

(2017) Horng D. Ou et al.   SCIENCE

Liquid-like behavior of chromatin

(2016) Kazuhiro Maeshima et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nucleosomal arrays self‐assemble into supramolecular globular structures lacking 30‐nm fibers

(2016) Kazuhiro Maeshima et al.   EMBO JOURNAL

Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo

(2015) Maria Aurelia Ricci et al.   CELL

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation

(2015) Hilmar Strickfaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

HSP70 Transgene Directed Motion to Nuclear Speckles Facilitates Heat Shock Activation

(2014) Nimish Khanna et al.   CURRENT BIOLOGY

Revisiting higher-order and large-scale chromatin organization

(2012) Qian Bian et al.   CURRENT OPINION IN CELL BIOLOGY

Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres

(2012) Eden Fussner et al.   EMBO REPORTS

Chromosomes without a 30-nm chromatin fiber

(2012) Yasumasa Joti et al.   Nucleus

Chromatin structure: does the 30-nm fibre exist in vivo?

(2010) Kazuhiro Maeshima et al.   CURRENT OPINION IN CELL BIOLOGY

Living without 30nm chromatin fibers

(2010) Eden Fussner et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

The H4 Tail Domain Participates in Intra- and Internucleosome Interactions with Protein and DNA during Folding and Oligomerization of Nucleosome Arrays

(2008) P.-Y. Kan et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ

(2008) M. Eltsov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA