Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting

CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures

(2021) Hong‐Tao Wang et al.   EPILEPSIA

Brain morphological abnormalities in children with cyclin-dependent kinase-like 5 deficiency disorder

(2021) Yingying Tang et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy

(2021) Priscilla D. Negraes et al.   MOLECULAR PSYCHIATRY

The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo

(2020) L. Trovò et al.   NEUROBIOLOGY OF DISEASE

Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms

(2020) Patrick J. Mulcahey et al.   EXPERIMENTAL NEUROLOGY

AMPA receptor dysregulation and therapeutic interventions in a mouse model of CDKL5 Deficiency Disorder

(2019) Madhumita Yennawar et al.   JOURNAL OF NEUROSCIENCE

Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?

(2019) Isabella Barbiero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model

(2019) Hui Wang et al.   PHYSIOLOGY & BEHAVIOR

Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder

(2019) I. Barbiero et al.   NEUROPHARMACOLOGY

Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry

(2018) Philipp Schätzle et al.   CURRENT BIOLOGY

CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder

(2018) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5

(2018) Marco Tramarin et al.   HUMAN MOLECULAR GENETICS

Neurosteroids: non-genomic pathways in neuroplasticity and involvement in neurological diseases

(2018) Marina Schverer et al.   PHARMACOLOGY & THERAPEUTICS

The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders

(2018) Micaela Lasser et al.   Frontiers in Cellular Neuroscience

Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

(2018) Claudia Fuchs et al.   NEURAL PLASTICITY

Molecular and Synaptic Bases of CDKL5 Disorder

(2018) Yong-Chuan Zhu et al.   Developmental Neurobiology

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

(2018) Lucas L Baltussen et al.   EMBO JOURNAL

Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects

(2018) Lejla Colic et al.   BEHAVIOURAL BRAIN RESEARCH

The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex

(2017) Isabella Barbiero et al.   HUMAN MOLECULAR GENETICS

Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice

(2017) Sheng Tang et al.   JOURNAL OF NEUROSCIENCE

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

(2017) Erik W. Dent   MOLECULAR BIOLOGY OF THE CELL

Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1

(2016) Grazia Della Sala et al.   BIOLOGICAL PSYCHIATRY

Microtubule plus-end tracking proteins in neuronal development

(2016) Dieudonnée van de Willige et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microtubule and microtubule associated protein anomalies in psychiatric disease

(2016) Francesca Marchisella et al.   Cytoskeleton

Neurosteroids and potential therapeutics: Focus on pregnenolone

(2016) Monique Vallée   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex

(2016) Riccardo Pizzo et al.   Frontiers in Cellular Neuroscience

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia

(2015) Micah A. Shelton et al.   BIOLOGICAL PSYCHIATRY

Erratum: A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

(2015) Farzaneh Larti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Effects of the Synthetic Neurosteroid

(2015) Lucie Parésys et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Post-translational modifications of tubulin

(2014) Maria M. Magiera et al.   CURRENT BIOLOGY

Overexpression of MAP-2 via Formation of Microtubules Plays an Important Role in the Sprouting of Mossy Fibers in Epileptic Rats

(2014) Li Tang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Randomized, Double-Blind, Placebo-Controlled Trial of Pregnenolone for Bipolar Depression

(2014) E Sherwood Brown et al.   NEUROPSYCHOPHARMACOLOGY

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

(2014) Elena Amendola et al.   PLoS One

Allopregnanolone Elevations Following Pregnenolone Administration Are Associated with Enhanced Activation of Emotion Regulation Neurocircuits

(2013) Rebecca K. Sripada et al.   BIOLOGICAL PSYCHIATRY

Assessment of steroidogenesis and steroidogenic enzyme functions

(2013) Van Luu-The   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

(2013) Christian Harteneck   MOLECULES

Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration

(2013) Jui-Hsia Weng et al.   Nature Chemical Biology

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

(2012) Vanja Duric et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

3 -Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders

(2012) M. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

(2012) I.-T. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

(2012) Charlotte Kilstrup-Nielsen et al.   NEURAL PLASTICITY

Cytoplasmic Linker Proteins Regulate Neuronal Polarization through Microtubule and Growth Cone Dynamics

(2011) D. Neukirchen et al.   JOURNAL OF NEUROSCIENCE

CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology

(2011) L. Swiech et al.   JOURNAL OF NEUROSCIENCE

Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

(2011) Nataly Ladurelle et al.   PSYCHOPHARMACOLOGY

Association of Anxiety and Depression With Microtubule-Associated Protein 2– and Synaptopodin-Immunolabeled Dendrite and Spine Densities in Hippocampal CA3 of Older Humans

(2010) Ainie Soetanto et al.   ARCHIVES OF GENERAL PSYCHIATRY

CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling

(2010) Q. Chen et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation Controls Autoinhibition of Cytoplasmic Linker Protein-170

(2010) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease

(2010) Sabina Luchetti et al.   NEUROBIOLOGY OF AGING

Cytoskeletal alterations in rat hippocampus following chronic unpredictable mild stress and re-exposure to acute and chronic unpredictable mild stress

(2009) Can Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus

(2009) Massimiliano Bianchi et al.   SYNAPSE

CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

(2008) Laura Rusconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

(2008) X. Hu et al.   JOURNAL OF NEUROSCIENCE