CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder

Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors

(2017) Cian-Ling Jhang et al.   HUMAN MOLECULAR GENETICS

Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice

(2017) Raffaele Mazziotti et al.   HUMAN MOLECULAR GENETICS

CDKL5 deficiency entails sleep apneas in mice

(2017) Viviana Lo Martire et al.   JOURNAL OF SLEEP RESEARCH

CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility

(2017) Kosuke Okuda et al.   NEUROBIOLOGY OF DISEASE

In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides

(2017) Azam Bolhassani et al.   PEPTIDES

Accurate discrimination of the wake-sleep states of mice using non-invasive whole-body plethysmography

(2017) Stefano Bastianini et al.   Scientific Reports

Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1

(2016) Grazia Della Sala et al.   BIOLOGICAL PSYCHIATRY

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

(2016) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex

(2016) Riccardo Pizzo et al.   Frontiers in Cellular Neuroscience

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse

(2016) Ralph D. Hector et al.   PLoS One

Critical Determinants of Substrate Recognition by Cyclin-Dependent Kinase-like 5 (CDKL5)

(2015) Syouichi Katayama et al.   BIOCHEMISTRY

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

(2015) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

(2014) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

(2014) Elena Amendola et al.   PLoS One

Targeted delivery of Neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury

(2013) Bin Deng et al.   BIOMATERIALS

Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy

(2013) Michael W. Lawlor et al.   HUMAN MOLECULAR GENETICS

The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome

(2013) Stefania Trazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development

(2013) Y.-C. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-related behavioral abnormalities in synapsin knockout mice

(2012) Barbara Greco et al.   BEHAVIOURAL BRAIN RESEARCH

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells

(2012) Emanuele Valli et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome

(2012) Sandra Guidi et al.   BRAIN PATHOLOGY

Epilepsy in Rett syndrome, andCDKL5- andFOXG1-gene-related encephalopathies

(2012) Renzo Guerrini et al.   EPILEPSIA

The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy

(2012) Stephanie Fehr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Anxiety-Related Mechanisms of Respiratory Dysfunction in a Mouse Model of Rett Syndrome

(2012) J. Ren et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

(2012) Sara Ricciardi et al.   NATURE CELL BIOLOGY

The neuropathological consequences ofCDKL5mutation

(2012) S. M. L. Paine et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Historic, Clinical, and Prognostic Features of Epileptic Encephalopathies Caused by CDKL5 Mutations

(2012) Brian D. Moseley et al.   PEDIATRIC NEUROLOGY

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

(2012) I.-T. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates

(2012) D. J. Cook et al.   Science Translational Medicine

What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

(2012) Charlotte Kilstrup-Nielsen et al.   NEURAL PLASTICITY

A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain

(2011) Sarah L. Williamson et al.   HUMAN GENETICS

TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke

(2010) Xingchun Gou et al.   JOURNAL OF DRUG TARGETING

Successful TAT-mediated enzyme replacement therapy in a mouse model of mitochondrial E3 deficiency

(2010) Matan Rapoport et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling

(2010) Q. Chen et al.   JOURNAL OF NEUROSCIENCE

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(2010) Koji Higuchi et al.   MOLECULAR MEDICINE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Biological responses towards cationic peptides and drug carriers

(2010) Wouter P.R. Verdurmen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Amphetamine-induced sensitization and spontaneous stereotypy in deer mice

(2009) Yoko Tanimura et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Trans-activator of Transcription-mediated Delivery of NEP1-40 Protein into Brain Has a Neuroprotective Effect against Focal Cerebral Ischemic Injury via Inhibition of Neuronal Apoptosis

(2008) Qiang Wang et al.   ANESTHESIOLOGY

Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1

(2008) Isamu Kameshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Key clinical features to identify girls with CDKL5 mutations

(2008) Nadia Bahi-Buisson et al.   BRAIN

TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity

(2008) Qiang Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

(2008) Laura Rusconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of Therapeutic Proteins as Secretable TAT Fusion Products

(2008) Marcella Flinterman et al.   MOLECULAR THERAPY