Article
Neurosciences
Shigeyuki Chaki, Mai Watanabe
Summary: The current efficacy of available medications for depression is unsatisfactory, leading to the development of novel antidepressants based on alternative hypotheses. Recent studies have highlighted the importance of the glutamatergic system as a drug target for depression, supported by the discovery of the antidepressant effects of ketamine. However, both ketamine and esketamine have unwanted adverse effects, prompting the search for agents with a similar antidepressant profile but with fewer side effects. Clinical trials of these agents are underway, with AUVELITYTM (AXS-05; dextromethorphan with bupropion) receiving approval from the United States Food and Drug Administration in 2022. Drug development of post-ketamine agents aims to provide safer antidepressants that are as potent and rapidly acting as ketamine.
Article
Neurosciences
Bing Zhang, Xili Yang, Luyu Ye, Rui Liu, Binglu Ye, Weijia Du, Fuyi Shen, Qian Li, Fan Guo, Jinqi Liu, Fei Guo, Yang Li, Zhendong Xu, Zhiqiang Liu
Summary: Ketamine demonstrates rapid antidepressant effects at subanaesthetic doses, but the understanding of its mechanism is still limited. By increasing the excitability of the mPFC, ketamine exerts its antidepressant effects, with a critical role played by the GABAergic system in the mPFC.
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Benjamin Fredrick Gruenbaum, Alexander Zlotnik, Amit Frenkel, Ilya Fleidervish, Matthew Boyko
Summary: Depression is a leading cause of disability globally, yet conventional antidepressant therapies often prove ineffective. Recent studies have identified promising glutamate-based approaches as alternatives to traditional treatments. This review explores the involvement of the glutamate system in depression and offers new insights into therapeutic strategies, particularly in relation to blood-brain barrier permeability. The authors propose further investigation into the use of blood glutamate scavengers for conditions associated with impaired blood-brain barrier function, including depression following stroke or traumatic brain injury, and neurodegenerative diseases.
Article
Neurosciences
Qiuxia Wu, Jinsong Tang, Chang Qi, An Xie, Jianbin Liu, Joseph O'Neill, Tieqiao Liu, Wei Hao, Yanhui Liao
Summary: This study provides the first evidence that chronic ketamine users have higher glutamatergic activity in the mPFC than healthy controls, which may offer new insights for the treatment of depression with ketamine.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Katherine S. Matho, Dhananjay Huilgol, William Galbavy, Miao He, Gukhan Kim, Xu An, Jiangteng Lu, Priscilla Wu, Daniela J. Di Bella, Ashwin S. Shetty, Ramesh Palaniswamy, Joshua Hatfield, Ricardo Raudales, Arun Narasimhan, Eric Gamache, Jesse M. Levine, Jason Tucciarone, Eric Szelenyi, Julie A. Harris, Partha P. Mitra, Pavel Osten, Paola Arlotta, Z. Josh Huang
Summary: The study established genetic strategies and tools to dissect and fate-map subpopulations of pyramidal neurons based on their developmental and molecular programs. Through combinatorial strategies, subsets of pyramidal neurons defined by developmental origin, marker expression, anatomical location, and projection targets can be targeted for viral access. These strategies provide an experimental framework for understanding the hierarchical organization and developmental trajectory of subpopulations of pyramidal neurons.
Article
Pharmacology & Pharmacy
Nafsika Poulia, Foteini Delis, Charalampos Brakatselos, George Ntoulas, Michail-Zois Asprogerakas, Katerina Antoniou
Summary: This study evaluated neuroplastic changes induced by repeated KET administration and assessed the modulatory role of CBD treatment. The results showed that CBD treatment could reverse the increase in motor activity and region-dependent alterations in glutamate receptors and ERK1/2 activation caused by KET administration.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ya-Ting Wang, Ning-Ning Zhang, Ling-Jie Liu, Hong Jiang, Die Hu, Zhen-Zhen Wang, Nai-Hong Chen, Yi Zhang
Summary: This review aims to explore the convergent downstream pathways of ketamine and rapastinel in order to drive the development of next-generation rapid-acting antidepressants. The findings reveal that ketamine and rapastinel exert antidepressant effects through the BDNF and mTORC1 pathways, contributing to synaptic plasticity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazzi
Summary: Traumatic stress is a significant risk factor for psychiatric disorders. This study investigates the effects of acute footshock stress and ketamine on the glutamatergic synaptic plasticity in the prefrontal cortex. The findings suggest that acute stress and ketamine induce changes in dopamine-dependent long-term potentiation (LTP) as well as ionotropic glutamate receptor subunit expression and localization. Further research is needed, but this initial report supports the potential benefit of acute ketamine in mitigating the impact of acute traumatic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chintha Venkataramaiah, Sholapuri Payani, Bandila Lakshmi Priya, Jangampalli Adi Pradeepkiran
Summary: The glutamate and dopamine hypotheses are leading theories in the pathophysiology of schizophrenia, and new neuroprotective compounds from medicinal plants could offer benefits. A novel bioactive compound found in Celastrus paniculatus shows potential neuroprotective effects in ketamine-induced schizophrenia, particularly in regulating glutamate metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Clinical Neurology
Adem Tevfik Can, Jules Shamus Mitchell, Megan Dutton, Maxwell Bennett, Daniel Francis Hermens, Jim Lagopoulos
Summary: Suicidality is a prevalent mental health condition that lacks rapid-acting, effective treatment options. There is a need for new treatments to manage suicidal patients and prevent suicide. Understanding the neurobiology underlying suicidal behavior is crucial in developing these treatments.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alexandra V. Griflyuk, Tatyana Y. Postnikova, Sergey L. Malkin, Aleksey V. Zaitsev
Summary: Febrile seizures during early childhood can cause central nervous system developmental disorders. The specific mechanisms of how febrile seizures affect the developing brain are not well understood. In this study, we used a hyperthermic model of febrile seizures in 10-day-old rats and tracked their development for two months. Our findings suggest that febrile seizures reduce the number of neurons in various regions of the hippocampus and impair glutamatergic transmission, leading to decreased local field potential amplitude.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Eric D. Melonakos, Morgan J. Siegmann, Charles Rey, Christopher O'Brien, Ksenia K. Nikolaeva, Ken Solt, Christa J. Nehs
Summary: The effectiveness of parabrachial nucleus excitation in altering the neurophysiological and behavioral effects of anesthesia appears to depend on the specific molecular target of the anesthetic.
Article
Cell Biology
Pei-Yi Lin, Z. Zack Ma, Melissa Mahgoub, Ege T. Kavalali, Lisa M. Monteggia
Summary: Ketamine's rapid antidepressant action is dependent on BDNF-TrkB signaling in CA1 neurons and a specific synaptic locus, suggesting the importance of synaptic potentiation in the hippocampus for its therapeutic effects.
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Neurosciences
Jasmin M. Kizilirmak, Joram Soch, Hartmut Schuetze, Emrah Duezel, Hannah Feldhoff, Larissa Fischer, Lea Knopf, Anne Maass, Matthias Raschick, Annika Schult, Renat Yakupov, Anni Richter, Bjoern H. Schott
Summary: The default mode network (DMN) shows decreased activity during demanding tasks and increased activity during rest. In young healthy adults, increased DMN activity during memory encoding predicts later forgetting; however, this association is attenuated in older adults, and in some cases, increased DMN activity predicts remembering. This study examines the relationship between DMN activity during encoding and at rest in young and older adults, and finds that older adults have lower resting-state DMN activity and reduced task-related deactivations. Higher resting-state DMN activity is associated with better memory performance in older adults, emphasizing the importance of maintaining DMN modulation in old age.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Anni Richter, Joram Soch, Jasmin M. Kizilirmak, Larissa Fischer, Hartmut Schutze, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Lea Knopf, Matthias Raschick, Annika Schult, Constanze I. Seidenbecher, Renat Yakupov, Emrah Duezel, Bjorn H. Schott
Summary: In this study, we investigated the associations between two single-value scores and brain function and cognitive changes in middle-aged and older adults. The results showed that these scores were related to memory recall performance and one of the scores also correlated with brain gray matter and other neuropsychological measures. This suggests that single-value scores of memory-related fMRI provide valuable information about network dysfunction in individuals and age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Ersin Ersoezlue, Robert Perneczky, Maia Tato, Julia Utecht, Carolin Kurz, Jan Hackert, Selim Guersel, Lena Burow, Gabriele Koller, Sophia Stoecklein, Daniel Keeser, Boris Papazov, Marie Totzke, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Stefan Teipel, Chantal Unterfeld, Michael Wagner, Xiao Wang, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Duezel, Frank Jessen, Boris-Stephan Rauchmann
Summary: Cognitive reserve (CR) explains inter-individual differences in the impact of neurodegenerative burden on cognitive functioning. This study explored the associations between residual CR markers (CRM) and intrinsic network connectivity (INC) in Alzheimer's disease neuropathological continuum. The results showed that INC was positively associated with CRM in the default mode network (DMN), and CRM was positively associated with the anti-correlation between memory-related regions in the frontoparietal network (FPN) and DMN in ADN and A+T/N+.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Matthias Raschick, Anni Richter, Larissa Fischer, Lea Knopf, Annika Schult, Renat Yakupov, Gusalija Behnisch, Karina Guttek, Emrah Duezel, Ildiko Rita Dunay, Constanze I. Seidenbecher, Burkhart Schraven, Dirk Reinhold, Bjoern H. Schott
Summary: Human cognitive abilities, especially hippocampus-dependent memory, usually decline with age. Immunosenescence, the age-related deterioration of the immune system, is becoming a focus of research as a significant factor contributing to cognitive decline. In this study, the potential associations between plasma levels of pro- and anti-inflammatory cytokines and learning and memory performance, as well as hippocampal anatomy, were investigated in young and older adults. The results suggest that endogenous anti-inflammatory mechanisms may act as protective factors in neurocognitive aging.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Geriatrics & Gerontology
Tommaso Ballarini, Elizabeth Kuhn, Sandra Roeske, Slawek Altenstein, Claudia Bartels, Friederike Buchholz, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, Tatjana Gabelin, Wenzel Glanz, Doreen Goerss, John Dylan Haynes, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Xenia Kobeleva, Christoph Laske, Andrea Lohse, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peter, Josef Priller, Boris-Stephan Rauchman, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike Jakob Sprut, Stefan Teipel, Jens Wiltfang, Steffen Wolfsgruber, Emrah Duezel, Frank Jessen, Michael Wagner
Summary: Previous studies have shown that bilingualism has a protective effect against dementia. This study aimed to investigate the impact of bilingualism at different life stages on cognition and brain structure in older adulthood. The findings revealed that bilingual individuals who used both languages in their early and middle life stages performed better in learning and memory tasks compared to monolinguals. However, there was no significant effect of bilingualism in the old life stage. These results suggest that bilingualism in early life may have a long-lasting protective effect on cognition and shape the brain to sustain cognitive performance in older adulthood.
NEUROBIOLOGY OF AGING
(2023)
Article
Clinical Neurology
Zerrin Yildirim, Firuze Delen, David Berron, Hannah Baumeister, Gabriel Ziegler, Hartmut Schuetze, Wenzel Glanz, Laura Dobisch, Oliver Peters, Silka Dawn Freiesleben, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern-Hendrik Schott, Dix Meiberth, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Michael Ewers, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Steffen Wolfsgruber, Renat Yakupov, Matthias Schmid, Moritz Berger, Hakan Gurvit, Frank Jessen, Emrah Duzel
Summary: In preclinical Alzheimer's disease, individuals in stage 1 with amyloid pathology have larger brain volumes in memory-related regions compared to asymptomatic amyloid-negative older adults. In stage 2, individuals with subjective cognitive decline (SCD) have smaller brain volumes. This suggests the presence of a brain reserve mechanism that allows individuals with amyloid pathology to remain cognitively normal in stage 1.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Psychiatry
Lena Vera Danyeli, Zuemruet Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Goetting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk, Meng Li, Martin Walter
Summary: Ketamine exhibits rapid antidepressant effects within 24 hours of administration, potentially through altering glutamatergic metabolite levels and resting-state functional connectivity within the default mode network. It is suggested that ketamine has a multistage drug effect, with acute effects on dysfunctional network configuration and delayed effects on synaptic plasticity. The association between delayed antidepressant-related changes in the default mode network and immediate changes remains unknown.
TRANSLATIONAL PSYCHIATRY
(2023)
Correction
Psychiatry
Lena Vera Danyeli, Zuemruet Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Goetting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk, Meng Li, Martin Walter
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Immunology
Alejandra P. Gara, Lorena Morton, Eva Pallinger, Edit Buzas, Stefanie Schreiber, Bjom H. Schott, Ildiko Rita Dunay
Summary: Tobacco smoking is strongly associated with vascular damage, hypertension, atherosclerosis, and increased risk for neurodegeneration. The involvement of the innate immune system in the development of vascular damage caused by chronic tobacco use before the onset of clinical symptoms is not fully understood. This study reveals distinct immune alterations in asymptomatic chronic smokers, indicating a dysregulated immuno-vascular axis and its potential contribution to neurodegenerative disorders.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Psychiatry
Nooshin Javaheripour, Lejla Colic, Nils Opel, Meng Li, Somayeh Maleki Balajoo, Tara Chand, Johan van der Meer, Marina Krylova, Igor Izyurov, Tina Meller, Janik Goltermann, Nils R. Winter, Susanne Meinert, Dominik Grotegerd, Andreas Jansen, Nina Alexander, Paula Usemann, Florian Thomas-Odenthal, Ulrika Evermann, Adrian Wroblewski, Katharina Brosch, Frederike Stein, Tim Hahn, Benjamin Straube, Axel Krug, Igor Nenadic, Tilo Kircher, Ilona Croy, Udo Dannlowski, Gerd Wagner, Martin Walter
Summary: Temporal neural synchrony disruption is associated with various symptoms of major depressive disorder, and altered dynamic neural synchrony may contribute to the persistence and worsening of these symptoms. Using the hidden Markov model on resting-state functional magnetic resonance imaging data, this study compared the brain functional dynamics in patients with MDD and healthy controls, revealing disrupted brain functional synchrony and its association with depression severity in MDD.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Luisa Herrmann, Johanna Ade, Anne Kuehnel, Annina Widmann, Liliana Ramona Demenescu, Meng Li, Nils Opel, Oliver Speck, Martin Walter, Lejla Colic
Summary: High childhood emotional maltreatment (CM-EMO) is associated with an increased risk for psychopathology, potentially through alterations in gamma-Aminobutyric acid (GABA). The pregenual anterior cingulate cortex (pgACC) is an important brain region for emotion processing, and its' GABA levels are implicated in mood and anxiety disorders. This study examined the association between self-reported CM-EMO in adulthood and GABA+ levels in the pgACC, finding a negative relationship between CM-EMO-NEG and GABA+/tCr in the pgACC.
NEUROBIOLOGY OF STRESS
(2023)
Article
Neurosciences
Christopher Stolz, Ariane Bulla, Joram Soch, Bjoern H. Schott, Anni Richter
Summary: This study found that the personality trait of Openness is associated with better episodic memory performance in older adults, and this relationship may be partially mediated by the preservation of the brain's memory network.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Petzold, Sebastian Schmitter, Berk Silemek, Lukas Winter, Oliver Speck, Bernd Ittermann, Frank Seifert
Summary: This study investigates the safety and performance aspects of parallel-transmit RF control modes for a body coil at B-0 <= 3T using electromagnetic simulations. The results show that PTx body coils can be used safely at B-0 <= 3T, but uncertainties in patient anatomy must be taken into account.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)