Article
Chemistry, Multidisciplinary
Katie Ruffell, Frances R. Smith, Michael T. Green, Simon M. Nicolle, Martyn Inman, William Lewis, Christopher J. Hayes, Christopher J. Moody
Summary: Diazophosphonates, prepared from alpha-ketophosphonates by oxidation, are useful reagents in 1,3-dipolar cycloaddition reactions for synthesizing N-H pyrazoles. They possess stable properties compared to less stable diazoalkanes, and can migrate during the cycloaddition process.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Xiaoying Zou, Lvyin Zheng, Xiaoya Zhuo, Yumei Zhong, Yingying Wu, Beining Yang, Qifang He, Wei Guo
Summary: A copper-promoted aerobic oxidative [3+2] cyclo-addition reaction is developed for the synthesis of substituted pyrazoles from N,N-disubstituted hydrazines and alkynoates in the presence of bases. This work involves direct C(sp(3))-H functionalization and the formation of new C-C/C-N bonds. In this strategy, inexpensive and easily available Cu2O serves as the promoter and air acts as the green oxidant. The reaction exhibits the advantages of high atom and step economy, high regioselectivity, and easy operation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xiaoying Zou, Lvyin Zheng, Xiaoya Zhuo, Yumei Zhong, Yingying Wu, Beining Yang, Qifang He, Wei Guo
Summary: A copper-promoted aerobic oxidative [3+2] cycloaddition reaction has been developed for the synthesis of substituted pyrazoles from N,N-disubstituted hydrazines and alkynoates in the presence of bases. This strategy involves direct C(sp3)-H functionalization and the formation of new C-C/C-N bonds, using inexpensive and easily available Cu2O as the promoter and air as the green oxidant. The reaction demonstrates advantages such as high atom and step economy, high regioselectivity, and easy operation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Lang Liu, Guojin Sun, Jun Zhang
Summary: This study presents a protocol for synthesizing 2,4,5-substituted imidazole-bearing methyl groups using A3-coupling cyclization with calcium carbide as the acetylene source, reacting with amidines and aldehydes. This methodology is characterized by several features, including the utilization of a solid alkyne source, readily accessible starting materials, and applicability to 34 examples.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Pei-Wen Yang, Xin-Xin Liu, Xue-Qiang Li, Meng-Xue Wei
Summary: Inexpensive and easily accessible calcium carbide has been developed as a promoter for the transition metal-free, solvent-free and one-pot conversion of acid chlorides and DMSO to beta-keto sulfoxides. Four drug molecules were successfully converted to their beta-keto sulfoxides using this method, highlighting its potential utility in medicinal chemistry.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Ricardo Meyrelles, Yener Fetisleam, Boris Maryasin
Summary: This study presents a computational analysis of the aza-Cope rearrangement, which leads to angularly substituted 1-azabicyclic ring systems. The calculations estimate the probability of proton transfer between reaction intermediates and solvents, explain the observed reaction selectivity, and propose new potentially more efficient systems for further in vitro and in vivo investigations.
Article
Chemistry, Inorganic & Nuclear
Felipe S. Stefanello, Yuri G. Kappenberg, Juliane N. Araujo, Steffany Z. Franceschini, Nilo Zanatta, Bernardo A. Iglesias, Helio G. Bonacorso, Marcos A. P. Martins
Summary: This paper describes an efficient approach to synthesize a novel trifluoromethylated heterocyclic system using aryldiazenyl as starting materials. The [3 + 3] cyclocondensation reaction between (E)-4-(aryldiazenyl)-1H-pyrazol-3,5-diamines and selected 4-alkoxy-4-(alkyl/aryl/heteroaryl)-1,1,1-trifluoroalk-3-en-2-ones was performed under reflux conditions in acetonitrile and sodium acetate, resulting in 50-90% yields. The synthesized compounds were characterized by NMR and SC-XRD techniques, and their electronic properties were investigated, revealing potential applications in the future.
JOURNAL OF FLUORINE CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Vincenzo Algieri, Cristina Algieri, Loredana Maiuolo, Antonio De Nino, Alessandra Pagliarani, Matteo Antonio Tallarida, Fabiana Trombetti, Salvatore Nesci
Summary: The study identified two 1,5-disubstituted 1,2,3-triazole derivatives that inhibit the opening of the mitochondrial permeability transition pore without affecting mitochondrial respiration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Chemistry, Organic
Zhenrong Liu, Zheng Li
Summary: This study presents a simple method for the synthesis of 1,3-diynes from iodoarenes using calcium carbide as an alkyne source and air as an oxidant, resulting in the efficient synthesis of a series of 1,4-diarylbuta-1,3-diynes. The key features of this protocol include the use of inexpensive and easy-to-handle alkyne source, broad substrate scope, open-air condition, and simple operation procedure.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Xiang Gao, H. Evan Bush, James Miller, Alicia Bayon, Ivan Ermanoski, Andrea Ambrosini, Ellen B. Stechel
Summary: Inorganic nitride materials have gained importance due to their potential as catalysts for NH3 synthesis. Ternary and higher-order nitrides with high metal-to-nitrogen ratios show promise in enhancing NH3 synthesis. However, the stability of nitrogen triple bonds has hindered the production of complex nitride compounds. This study presents a down-selection process to identify promising ternary nitrides and reports a two-step synthesis method for well-characterized ternary and quaternary nitrides.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Organic
Qian Wang, Zhiqiang Wang, Zheng Li
Summary: The method described in this study uses inexpensive and easily handled solid alkyne as a replacement for flammable and explosive gaseous acetylene, with high stereoselectivity and simple workup procedures. It is also capable of being scaled up for gram-scale synthesis.
Article
Chemistry, Organic
Qian Wang, Zheng Li
Summary: An efficient method for the synthesis of N-aroyl-2-arylindoles using calcium carbide as an alkyne source is described. This one-step procedure replaces the use of flammable and explosive acetylene. The method offers advantages such as wide substrate scope, satisfactory yield, and simple workup procedures.
Article
Chemistry, Multidisciplinary
Yue Wang, Fei Wen, Zheng Li
Summary: This article describes an efficient selective monoethynylation method using calcium carbide as a solid alkyne source. The protocol offers a cost-effective and user-friendly alternative to gaseous acetylene, with the advantages of transition-metal-free and mild conditions, wide substrate scope, high selectivity, high yield, and simple work-up procedure.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xiaolong Ma, Zhiqiang Wang, Zhenrong Liu, Zheng Li
Summary: The method utilizes calcium carbide as a solid alkyne source to efficiently synthesize 2-methyl-3-aminobenzofurans, avoiding the use of flammable and explosive acetylene gas. It offers the advantages of being cost-effective, abundant, and easy to handle.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Pal D. Manisha, Ruchi Chawla, Pradip Kumar Dutta
Summary: In this study, chitosan was modified via click chemistry to synthesize chitosan-1,2,3-triazole derivative. The synthesized derivative showed superior antibacterial activity and antioxidant property.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.