Article
Chemistry, Applied
Vighneshwar Shridhar Bhat, Anna Lee
Summary: A one-pot, three-component synthesis of 3-arylsulfonylated thioflavones has been developed, where the reactions were carried out without using any catalysts or additives, and the desired products were obtained through intramolecular radical cyclization. This method provides an alternative route for the synthesis of thioflavone derivatives, which have been found in various bioactive compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Sure Siva Prasad, Dirgha Raj Joshi, Ikyon Kim
Summary: A method to directly access diarylmethylazides, versatile intermediates, was developed from commercially available starting materials via a three-component coupling reaction in the presence of a catalyst. This approach simplifies the synthetic steps and provides a versatile intermediate for further transformations.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Applied
Jianjing Yang, Ting Zeng, Kelu Yan, Zonghui Qin, Jiangwei Wen
Summary: This study successfully developed a one-pot three-component cross-coupling reaction mediated by electrolysis, which provides a straightforward method for the synthesis of alkylthioimidazoles without the need for metal catalysts and oxidants. Water is used as the co-solvent at room temperature.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Medicinal
Tommaso Felicetti, Maria Sole Burali, Chin Piaw Gwee, Kitti Wing Ki Chan, Sylvie Alonso, Serena Massari, Stefano Sabatini, Oriana Tabarrini, Maria Letizia Barreca, Violetta Cecchetti, Subhash G. Vasudevan, Giuseppe Manfroni
Summary: A sustainable three-component reaction (3CR) was developed for synthesizing PBTZ analogues with broad-spectrum anti-flavivirus activity, with compound 22 identified as the best inhibitor in a new series. These results support PBTZ derivatives as promising anti-flavivirus agents for further development studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Polymer Science
Burcu Alkan, Ozgun Daglar, Serter Luleburgaz, Begum Gungor, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: A novel one-pot cascade reaction was proposed for the synthesis and simultaneous modification of polyesters, utilizing the Passerini three-component reaction. The study emphasized the significance of temperature in achieving high molecular weight polymers and efficient reactions.
Article
Chemistry, Organic
Zhao Long, Yang Maolin, Chen Haoran, Ding Mingwu
Summary: A new one-pot synthesis of 3,4-dihydroquinazolines by diethyl azodicarboxylate (DEAD)-promoted oxidative Ugi/aza-Wittig reaction was developed. The reactions of iminophosphoranes 5, N-aryl-1,2,3,4-tetrahydroisoquinolines 6 and acids 7 produced 3-(tetrahydroisoquinolin-1-formyl) substituted 3,4-dihydroquinazolines 8 in moderate to good yields in the presence of DEAD by tandem oxidative Ugi/aza-Wittig reaction.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Hassan Allouchi, Mohamed Abarbri, Fakher Chabchoub
Summary: A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives were synthesized using a one-pot three-component synthesis. The structures of the compounds were confirmed by various analyses. The compounds were evaluated for their antitumor activity and displayed promising results against cancer cell lines.
Article
Chemistry, Physical
Mohammad Mehdi Vahedi, Sakineh Asghari, Mahmood Tajbakhsh, Mojtaba Mohseni, Asieh Khalilpour
Summary: Pyrano[3,2- e]pyrazaolo[1,5-a]pyrimidine derivatives were efficiently synthesized through three-component reactions, with high yields of 80-89%. The synthesized compounds were structurally identified using various analytical techniques. The compounds were evaluated for their anti-cancer, antioxidant, and antibacterial activities, and compound 4l showed the most potent anti-cancer activity and compound 4h exhibited the highest free radical scavenging effect. The synthesized compounds also exhibited modest antibacterial activity against Gram-positive bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Xiao-Ping Liang, Min Luo, Li Kang, Long-Xing Tang, Qing Liang, Yuan-Lin Liu, Zi Yang, Chun-Tao Zhang, Cai-Yun Peng, Rong-Geng Fu
Summary: A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives through a three-component cascade reaction is reported. The reaction involves aromatic methyl ketones, elemental sulfur, and cyanamide, and forms one C-N bond and two C-S bonds in one-pot protocol without using catalysts.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Simra Faraz, Abu Taleb Khan
Summary: A green synthesis of 2,3-diarylquinolines is presented using a one-pot three-component reaction with arylamines, benzaldehyde, and styrene oxide. The reaction is catalyzed by 20 mol% p-TSA center dot H2O at 120 degrees C and does not require metal catalysts, additives, or extra oxidants. This method is advantageous due to its simplicity, wide substrate scope, short reaction time, high atom economy, regioselectivity, and good yields. In a single step, it forms one C-N bond and two C-C bonds.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Baofu Zhu, Jiaming He, Kai Zou, Anquan Li, Chen Zhang, Jiaji Zhao, Hua Cao
Summary: This study established a three-component reaction catalyzed by base, involving ynals, isocyanates, amines, and alcohols. The strategy enables a wide range of substrates and provides a simple process for the preparation of diverse pyridine derivatives with good yields and high regioselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Vipin K. Pandey, Chandra Shekhar Tiwari, Arnab Rit
Summary: A silver salt-catalyzed aminophosphonylation and Strecker reaction were developed, and mechanistic studies revealed a radical pathway. This reaction system can effectively operate at room temperature without the need for solvents, ligands, or bases, and it can produce diverse products.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Organic
Fathy M. Abdelrazek, Sobhi M. Gomha, Mohamed S. Farghaly, Peter Metz
Summary: Grinding a mixture of specific compounds in the presence of aluminate sulfonic acid nanoparticles under solvent-free conditions resulted in the synthesis of pyrido[2,3-d]pyrimidinone derivatives and ethyl 5-oxo-1-aryl-6,7,8-triphenyl-1,5,6,9-tetrahydropyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-3-carboxylate derivatives. The method offers advantages such as high yields, short reaction time, easy workup, and reusability of the catalyst.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Physical
Jia Wu, Bao-Di Ma, Yi Xu
Summary: A novel and efficient one-pot three-enzyme cascade method was developed for the synthesis of beta-alanine from maleic acid. Two recombinant E. coli strains were constructed, allowing the conversion of maleic acid to L-aspartate via fumaric acid and then the conversion of L-aspartate to beta-alanine. By optimizing the reaction conditions for each strain, the whole cells of the two strains were combined for one-pot synthesis of beta-alanine. Under optimal conditions, the concentration of beta-alanine reached 751 mM after a 9 h reaction, with a yield of 93.9% and a space-time yield of 178 g/L/d. This new route demonstrates the potential for green and efficient biosynthesis of beta-alanine from a cheap substrate using tandem biocatalysts.
Article
Chemistry, Multidisciplinary
Angad B. Barkule, Yatin U. Gadkari, Simren S. Salim, Savita B. Lomte, Vikas N. Telvekar
Summary: An expeditious and highly efficient methodology for the synthesis of pyrazolopyranopyrimidine under aqueous conditions using guanidine hydrochloride as a catalyst is reported. The one-pot multicomponent synthesis from aryl/heterocyclic aldehyde, ethyl acetoacetate, barbituric acid, and hydrazine hydrate yields the final compound in moderate to excellent yield. The guanidine hydrochloride shows recyclability (up to 4 cycles), safety, low cost, and wide stability profile, making it an ideal catalyst. The current protocol offers advantages such as environmentally benign nature, shorter reaction time, high yield, simple work-up procedure, broad substrate tolerance, and absence of hazardous organic solvent.
Article
Chemistry, Applied
Sharad Kumar Suthar, Ajay Hooda, Ankesh Sharma, Sumit Bansal, Jitender Monga, Monika Chauhan, Manu Sharma
Summary: A method for extracting and isolating lantadene A from Lantana camara leaves was developed, with synthesised derivatives being used to optimise anti-inflammatory and anticancer properties. Through molecular docking studies, a 3β,22β-diisobutyl substituted lantadene derivative was identified as the most potent IKK inhibitor, demonstrating non-toxic and non-carcinogenic properties in in silico ADMET studies.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ashwani Kumar, Kiran Bagri, Manisha Nimbhal, Parvin Kumar
Summary: Alzheimer's disease is a common neurodegenerative disorder that poses an economic burden on developing countries. Research suggests that the use of Glutaminyl cyclase inhibitors can efficiently improve symptoms of the disease. The efficiency of Monte Carlo based QSAR modelling studies on a dataset of inhibitors shows promising results.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Jitender Monga, Indra Adrianto, Craig Rogers, Shirish Gadgeel, Dhananjay Chitale, Joshi J. Alumkal, Himisha Beltran, Amina Zoubeidi, Jagadananda Ghosh
Summary: This study demonstrates that TRIB2 is overexpressed in enzalutamide-resistant prostate cancer cells and tumors. Inhibition of TRIB2 decreases the viability of enzalutamide-resistant prostate cancer cells, while overexpression of TRIB2 confers resistance to clinically relevant doses of enzalutamide. TRIB2 downregulates luminal markers and upregulates neuronal markers in prostate cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Sandeep Lohan, Dindyal Mandal, Wonsuk Choi, Anastasia G. Konshina, Rakesh K. Tiwari, Roman G. Efremov, Innokentiy Maslennikov, Keykavous Parang
Summary: The study reports the synthesis of amphiphilic membrane-active peptides with broad-spectrum antibacterial activity, particularly effective against drug-resistant bacteria. The cyclic peptides were found to be more stable compared to their linear counterparts, and capable of disrupting bacterial cell membranes. Nuclear magnetic resonance spectroscopy and molecular dynamics simulation revealed the interaction mechanisms between these peptides and cell membranes.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Organic
Satbir Mor, Mohini Khatri, Ravinder Punia, Savita Nagoria, Suchita Sindhu
Summary: This review provides an overview of the available methodologies for the synthesis and diverse pharmacological activities of pyrazole based molecules reported by researchers from 1994 to 2021. It highlights recent reports on various routes of synthesis and potential biological evaluation studies of pyrazole derivatives in fields such as anticancer, AT (II) inhibitory, anti-inflammatory activities, HIV-1-RT inhibitory, antihypertensive, herbicidal, antitubercular, insecticidal, antiviral, antimicrobial, and COX-2 inhibitory activity.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Parvin Kumar, Ashwani Kumar, Sohan Lal, Devender Singh, Shahram Lotfi, Shahin Ahmadi
Summary: The present research article develops robust models for 1176 flavor and fragrance compounds using the QSRR approach on the OV-101 gas chromatography column. The models created using the CII parameter show better statistical results, with the model from T F 2 S plit 1 being acknowledged as the leading model. The study also discusses the structural attributes responsible for changes in the retention index of flavors and fragrances compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Cell Biology
David Salehi, Saghar Mozaffari, Khalid Zoghebi, Sandeep Lohan, Dindyal Mandal, Rakesh K. Tiwari, Keykavous Parang
Summary: A series of cyclic and linear peptides containing arginine and either tryptophan or diphenylalanine residues were synthesized and evaluated for their molecular transporter efficiency. Among them, the [DipR](5) peptide showed significantly improved uptake of small molecules and negatively charged molecules, such as siRNA and phosphopeptide, suggesting its potential as an efficient membrane transporter.
Article
Pharmacology & Pharmacy
Muhammad Imran Sajid, Dindyal Mandal, Naglaa Salem El-Sayed, Sandeep Lohan, Jonathan Moreno, Rakesh Kumar Tiwari
Summary: Recent approvals of siRNA-based products have led to exploration of siRNA as a potential treatment option for cancer and other diseases. This study introduces a series of oleyl-conjugated histidine-arginine peptides as a promising nonviral siRNA delivery tool.
Article
Infectious Diseases
Muhammad Imran Sajid, Sandeep Lohan, Shun Kato, Rakesh Kumar Tiwari
Summary: This study demonstrates the significant antimicrobial activity of the physical mixture of cyclic [R4W4] peptide and levofloxacin against various drug-resistant bacterial strains, and it is more effective than the covalent conjugate. The cytotoxicity of the cyclic [R4W4] peptide and levofloxacin conjugates is lower in breast cancer cells and normal kidney cells. The time-kill kinetic study shows rapid bactericidal action of the combination of [R4W4] and levofloxacin against drug-resistant bacteria.
Article
Chemistry, Medicinal
S. Mor, M. Khatri, S. Sindhu, R. Punia, S. Nagoria, A. Kumar, A. Kumar
Summary: A series of new thiazole based hydrazones were synthesized and evaluated for their antimicrobial and alpha-amylase inhibitory activities. Compound 3d exhibited the strongest antimicrobial activity against all tested bacterial and fungal strains. Derivatives 3j and 3k showed the best alpha-amylase inhibitory activity.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Review
Chemistry, Physical
Meena Devi, Parvin Kumar, Rahul Singh, Laxmi Narayan, Ashwani Kumar, Jayant Sindhu, Sohan Lal, Khalid Hussain, Devender Singh
Summary: The 1,4-naphthoquinone skeleton is an important component found in many biologically active natural products and chemotherapy agents. 1,4-naphthoquinones with electron donor amino substituents on specific positions have the potential to act as anion sensors and have various biological and industrial applications. 2,3-diamino-1,4-naphthoquinone is a promising bacteriostatic agent.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Energy & Fuels
Parvin Kumar, Ashwani Kumar, Jayant Sindhu, Sohan Lal
Summary: The CO2 capture capacity of deep eutectic solvents (DESs) can be mathematically described based on hydrogen bond acceptor, hydrogen bond donor, molar ratio, temperature, and pressure. Quasi-SMILES are used to represent DESs under different conditions and construct quantitative models. Different splits and sets are prepared from the dataset to develop QSPR models with good statistical quality. Consensus modeling is also performed to predict the robustness of the developed models, and the winner consensus model shows high determination coefficient and MAE (95%) values.
Article
Oncology
Jitender Monga, Frederick Valeriote, Clara Hwang, Shirish Gadgeel, Jagadananda Ghosh
Summary: FDA-approved enzalutamide is commonly prescribed for advanced prostate cancer, but resistance to enzalutamide inevitably develops. The molecular mechanism behind this resistance is not well understood. This study found that the overexpression of TRIB2 in enzalutamide-resistant prostate cancer cells plays a critical role in their survival. Daclatasvir (DCV), an antiviral drug, effectively inhibits TRIB2 and resensitizes the cancer cells to enzalutamide treatment, suggesting that DCV could be a promising therapy for enzalutamide-resistant prostate cancer.
MOLECULAR CANCER THERAPEUTICS
(2023)
Meeting Abstract
Oncology
Jitender Monga, Indra Adrianto, Craig Rogers, Shirish Gadgeel, Dhananjay Chitale, Jagadananda Ghosh
Review
Nanoscience & Nanotechnology
Ravinder Sindhu, Suchita Sindhu, Mukhan Wati Dagar, Savita Nagoria
Summary: Gold nanoparticles have unique properties that make them promising antimicrobial agents in biomedical applications.
INTERNATIONAL JOURNAL OF NANOSCIENCE
(2022)
