Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity

Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

(2020) Ali Khalilimeybodi et al.   PLoS Computational Biology

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming

(2019) Huan Wang et al.   Cell Systems

Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells

(2018) Sara Damiano et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance

(2018) Meng-Shih Weng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Network-based predictions of in vivo cardiac hypertrophy

(2018) Deborah U. Frank et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes

(2018) Yosuke K. Kurokawa et al.   TOXICOLOGY LETTERS

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

(2017) Hanna-Riikka Teppo et al.   Oxidative Medicine and Cellular Longevity

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

(2017) Arun Sharma et al.   Science Translational Medicine

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

(2017) Philip M. Tan et al.   PLoS Computational Biology

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

(2017) Timothy J. Stuhlmiller et al.   Journal of the American Heart Association

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics

(2017) Jaehee V. Shim et al.   Frontiers in Physiology

The Role of New Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

(2016) Priyanka A. Pophali et al.   CANCER JOURNAL

The Myocyte-Damaging Effects of the BCR-ABL1-Targeted Tyrosine Kinase Inhibitors Increase with Potency and Decrease with Specificity

(2016) Brian B. Hasinoff et al.   Cardiovascular Toxicology

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

(2016) A.C. Zeigler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes

(2016) Nishant Mohan et al.   MOLECULAR CANCER THERAPEUTICS

Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress

(2016) Hesham M. Korashy et al.   TOXICOLOGY LETTERS

Cardiotoxicity in targeted therapy for breast cancer: A study of the FDA adverse event reporting system (FAERS)

(2016) Saranrat Wittayanukorn et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism

(2015) Pamela Ann Harvey et al.   CARDIOVASCULAR RESEARCH

Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment

(2015) Mike Clements et al.   TOXICOLOGICAL SCIENCES

Downregulation of Stanniocalcin 1 Is Responsible for Sorafenib-Induced Cardiotoxicity

(2014) Miko Kawabata et al.   TOXICOLOGICAL SCIENCES

A Multi-parameter In Vitro Screen in Human Stem Cell-Derived Cardiomyocytes Identifies Ponatinib-Induced Structural and Functional Cardiac Toxicity

(2014) Dominique R. Talbert et al.   TOXICOLOGICAL SCIENCES

Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice

(2013) M. Khair ElZarrad et al.   PLoS One

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes

(2012) Peter P. Rainer et al.   BJU INTERNATIONAL

Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling

(2012) Karen A. Ryall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes

(2012) Manuel Chiusa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Characterization of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

(2012) Payal Rana et al.   TOXICOLOGICAL SCIENCES

Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death

(2011) Krishna K. Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty

(2011) Anthony R. Soltis et al.   BIOINFORMATICS

A Novel Preclinical Strategy for Identifying Cardiotoxic Kinase Inhibitors and Mechanisms of Cardiotoxicity

(2011) Hui Cheng et al.   CIRCULATION RESEARCH

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

(2011) J.D. Cohen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

(2010) Matthew J Kraeutler et al.   BMC Systems Biology

Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells

(2010) Yuqin Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

(2010) Brian B. Hasinoff et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation

(2009) Baohua Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION