Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

Personalized signaling models for personalized treatments

(2020) Julio Saez‐Rodriguez et al.   Molecular Systems Biology

Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

(2020) Federica Eduati et al.   Molecular Systems Biology

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy

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Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling

(2019) Parul Maheshwari et al.   PLoS Computational Biology

Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB)

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Network-based predictions of in vivo cardiac hypertrophy

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Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

BRENDA in 2019: a European ELIXIR core data resource

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Identifying (un)controllable dynamical behavior in complex networks

(2018) Jordan C. Rozum et al.   PLoS Computational Biology

Computational discovery of dynamic cell line specific Boolean networks from multiplex time-course data

(2018) Misbah Razzaq et al.   PLoS Computational Biology

Cardiac GPCR–Mediated EGFR Transactivation

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Investigating β-adrenergic-induced cardiac hypertrophy through computational approach: classical and non-classical pathways

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Data-driven reverse engineering of signaling pathways using ensembles of dynamic models

(2017) David Henriques et al.   PLoS Computational Biology

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

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Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

(2017) Le Shu et al.   PLoS Genetics

Network-based approaches for analysis of complex biological systems

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Inferring causal molecular networks: empirical assessment through a community-based effort

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Logical Modeling and Dynamical Analysis of Cellular Networks

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Systems biological approaches to the cardiac signaling network

(2015) Jun Hyuk Kang et al.   BRIEFINGS IN BIOINFORMATICS

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

A multi-criteria trajectory-based parameter sampling strategy for the screening method of elementary effects

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An analysis of critical factors for quantitative immunoblotting

(2015) Kevin A. Janes   Science Signaling

An analysis of critical factors for quantitative immunoblotting

(2015) Kevin A. Janes   Science Signaling

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy

(2015) Ersilia Cipolletta et al.   PLoS One

Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks

(2014) Ye Tian et al.   BMC Systems Biology

Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation

(2014) Karen A. Ryall et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Boolean modeling: a logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions

(2014) Réka Albert et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes

(2014) Sung-Young Shin et al.   Nature Communications

Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

(2013) Regina Samaga et al.   Cell Communication and Signaling

Personalized Network-Based Treatments in Oncology

(2013) X Robin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Perturbation Biology: Inferring Signaling Networks in Cellular Systems

(2013) Evan J. Molinelli et al.   PLoS Computational Biology

β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway

(2012) Marie Vidal et al.   CARDIOVASCULAR RESEARCH

Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation

(2012) Marcella Salzano et al.   CELL CYCLE

Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling

(2012) Karen A. Ryall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Cardiac Transcriptional Profiles Defining Pregnancy and Exercise

(2012) Eunhee Chung et al.   PLoS One

Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes

(2011) Mingming Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line

(2011) Ana F. Branco et al.   Cardiovascular Toxicology

Computational Models Reduce Complexity and Accelerate Insight Into Cardiac Signaling Networks

(2011) Jason H. Yang et al.   CIRCULATION RESEARCH

Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy

(2011) Gregory T. Bass et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dynamical and Structural Analysis of a T Cell Survival Network Identifies Novel Candidate Therapeutic Targets for Large Granular Lymphocyte Leukemia

(2011) Assieh Saadatpour et al.   PLoS Computational Biology

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

(2010) Izhak Kehat et al.   Annals of the New York Academy of Sciences

Logic-Based Models for the Analysis of Cell Signaling Networks

(2010) Melody K. Morris et al.   BIOCHEMISTRY

Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling

(2010) Anthony R. Soltis et al.   BIOPHYSICAL JOURNAL

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

(2010) Matthew J Kraeutler et al.   BMC Systems Biology

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

(2010) Sarah J. Watkins et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling

(2010) Shikha Mishra et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network

(2010) S.-Y. Shin et al.   JOURNAL OF CELL SCIENCE

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(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes

(2009) Michael T. Cooling et al.   BIOPHYSICAL JOURNAL

DY-9760e Inhibits Endothelin-1-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities

(2009) Ying-Mei Lu et al.   Cardiovascular Therapeutics

Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index

(2009) Andrea Saltelli et al.   COMPUTER PHYSICS COMMUNICATIONS

β-Adrenergic receptor signaling in the heart: Role of CaMKII

(2009) Michael Grimm et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Constraint-based network model of pathogen-immune system interactions

(2008) J. Thakar et al.   Journal of the Royal Society Interface

Network model of survival signaling in large granular lymphocyte leukemia

(2008) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA