A Multi-parameter In Vitro Screen in Human Stem Cell-Derived Cardiomyocytes Identifies Ponatinib-Induced Structural and Functional Cardiac Toxicity

Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies

(2013) Daryl Sonnichsen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

(2013) J.E. Cortes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival

(2013) E. M. Chislock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitativein vitrotoin vivoextrapolation of cell-based toxicity assay results

(2012) Miyoung Yoon et al.   CRITICAL REVIEWS IN TOXICOLOGY

Trends in chronic myeloid leukemia incidence and survival in the United States from 1975 to 2009

(2012) Yiming Chen et al.   LEUKEMIA & LYMPHOMA

Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias

(2012) Jorge E. Cortes et al.   NEW ENGLAND JOURNAL OF MEDICINE

High free fatty acids level related with cardiac dysfunction in obese rats

(2011) Xiaodong Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

(2010) Wei-Sheng Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I/II null mice

(2010) Ze Fu et al.   TOXICOLOGY IN VITRO

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

(2009) Thomas O'Hare et al.   CANCER CELL

Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue

(2009) Shigeki Miyamoto et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

c-Abl tyrosine kinase regulates cardiac growth and development

(2009) Z. Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION