Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism
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Title
Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 14, Pages 10429-10444
Publisher
American Chemical Society (ACS)
Online
2021-07-08
DOI
10.1021/acs.jmedchem.1c00858
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Note: Only part of the references are listed.- Antimicrobial host defence peptides: functions and clinical potential
- (2020) Neeloffer Mookherjee et al. NATURE REVIEWS DRUG DISCOVERY
- Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
- (2020) Fabian Grein et al. Nature Communications
- A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance
- (2020) James K. Martin et al. CELL
- Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections
- (2020) Shuimu Lin et al. JOURNAL OF MEDICINAL CHEMISTRY
- A cyclic derivative of host-defence peptide IDR-1018 improves proteolytic stability, suppresses inflammation, and enhances in vivo activity
- (2020) Hashem Etayash et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity Relationships of Daptomycin Lipopeptides
- (2020) John A. Karas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mode of action of teixobactins in cellular membranes
- (2020) Rhythm Shukla et al. Nature Communications
- Mechanistic Landscape of Membrane-Permeabilizing Peptides
- (2019) Shantanu Guha et al. CHEMICAL REVIEWS
- Intracellular effect of β3-adrenoceptor agonist Carazolol on skeletal muscle, a direct interaction with SERCA
- (2019) Ibrahim Ramirez-Soto et al. CELL CALCIUM
- Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria
- (2019) Jitendriya Swain et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Chimeric peptidomimetic antibiotics against Gram-negative bacteria
- (2019) Anatol Luther et al. NATURE
- Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
- (2019) Bálint Kintses et al. Nature Communications
- Peptides having antimicrobial activity and their complexes with transition metal ions
- (2018) Małgorzata Jeżowska-Bojczuk et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity
- (2018) Mônica Samuel Avila et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
- (2018) Evelina Tacconelli et al. LANCET INFECTIOUS DISEASES
- Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity
- (2017) Shuimu Lin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance
- (2017) Shuimu Lin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)
- (2017) Shuimu Lin et al. JOURNAL OF MEDICINAL CHEMISTRY
- A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail
- (2017) Debra A Goff et al. LANCET INFECTIOUS DISEASES
- Predictive compound accumulation rules yield a broad-spectrum antibiotic
- (2017) Michelle F. Richter et al. NATURE
- The drug-resistant bacteria that pose the greatest health threats
- (2017) Cassandra Willyard NATURE
- How Membrane-Active Peptides Get into Lipid Membranes
- (2016) Marc-Antoine Sani et al. ACCOUNTS OF CHEMICAL RESEARCH
- A Vancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria
- (2016) Venkateswarlu Yarlagadda et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes
- (2016) Douglas R. Rice et al. CHEMICAL COMMUNICATIONS
- Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications
- (2016) Richard W. Scott et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Antibiotics in the clinical pipeline at the end of 2015
- (2016) Mark S Butler et al. JOURNAL OF ANTIBIOTICS
- Antimicrobial Peptides: Mechanisms of Action and Resistance
- (2016) B. Bechinger et al. JOURNAL OF DENTAL RESEARCH
- New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues
- (2016) Louis Zimmermann et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-Infective
- (2016) Regis P. Kowalski et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficientAcinetobacter baumannii
- (2016) Joseph M. Boll et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-Activity Relationship Study of Novel Peptoids That Mimic the Structure of Antimicrobial Peptides
- (2015) Biljana Mojsoska et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A novel antimicrobial peptide, scolopendin, from Scolopendra subspinipes mutilans and its microbicidal mechanism
- (2015) Wonyoung Lee et al. BIOCHIMIE
- Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death
- (2015) Kasey J. Clear et al. BIOCONJUGATE CHEMISTRY
- Antimicrobial resistance: moving from professional engagement to public action
- (2015) D. Ashiru-Oredope et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A new antibiotic kills pathogens without detectable resistance
- (2015) Losee L. Ling et al. NATURE
- Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches
- (2014) Marie Stiborová et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections
- (2014) Jun-Jie Koh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Synthesis of New Benzimidazole–Carbazole Conjugates for the Stabilization of Human Telomeric DNA, Telomerase Inhibition, and Their Selective Action on Cancer Cells
- (2014) Basudeb Maji et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cu(ii) and Co(ii) ternary complexes of quinolone antimicrobial drug enoxacin and levofloxacin: structure and biological evaluation
- (2014) Wan-Yun Huang et al. RSC Advances
- Designing Mimics of Membrane Active Proteins
- (2013) Federica Sgolastra et al. ACCOUNTS OF CHEMICAL RESEARCH
- Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
- (2013) Kieron M. G. O'Connell et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Visualization of Peroxynitrite-Induced Changes of Labile Zn2+ in the Endoplasmic Reticulum with Benzoresorufin-Based Fluorescent Probes
- (2013) Wei Lin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Lipids of mitochondria
- (2013) Susanne E. Horvath et al. PROGRESS IN LIPID RESEARCH
- Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
- (2012) Babasaheb P. Bandgar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Antimicrobial Peptide Action on Parasites
- (2012) Marc Torrent et al. CURRENT DRUG TARGETS
- Challenges of Antibacterial Discovery
- (2011) L. L. Silver CLINICAL MICROBIOLOGY REVIEWS
- A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption
- (2011) Johan Isaksson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents
- (2010) Smritilekha Bera et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid
- (2010) Wen Gu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Evolution of MRSA During Hospital Transmission and Intercontinental Spread
- (2010) S. R. Harris et al. SCIENCE
- Antimicrobial Action of Prototypic Amphipathic Cationic Decapeptides and Their Branched Dimers
- (2009) Pooja C. Dewan et al. BIOCHEMISTRY
- Antifungal Carbazoles
- (2009) Karin Thevissen et al. CURRENT MEDICINAL CHEMISTRY
- Induction of membrane permeability inEscherichia coliâmediated by lysis protein of the ColE7 operon
- (2009) Lung J.R. Lin et al. FEMS MICROBIOLOGY LETTERS
- Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens
- (2009) Sung-Hoon Lee et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity
- (2009) Ramesh Rathinakumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics
- (2008) M. Zorko et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Zinc(II) Coordination Complexes as Membrane-Active Fluorescent Probes and Antibiotics
- (2007) Kristy M. DiVittorio et al. CHEMBIOCHEM
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