A Vancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Membrane Disruption and Enhanced Inhibition of Cell-Wall Biosynthesis: A Synergistic Approach to Tackle Vancomycin-Resistant Bacteria

(2015) Venkateswarlu Yarlagadda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

(2015) Bala Kishan Gorityala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amphiphilic Tobramycins with Immunomodulatory Properties

(2015) Goutam Guchhait et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents

(2015) Yamin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death

(2015) Kasey J. Clear et al.   BIOCONJUGATE CHEMISTRY

Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria

(2015) Venkateswarlu Yarlagadda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

(2015) Steven Y. C. Tong et al.   CLINICAL MICROBIOLOGY REVIEWS

In vivo antibacterial activity and pharmacological properties of the membrane-active glycopeptide antibiotic YV11455

(2015) Venkateswarlu Yarlagadda et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vivo efficacy and pharmacological properties of a novel glycopeptide (YV4465) against vancomycin-intermediate Staphylococcus aureus

(2015) Venkateswarlu Yarlagadda et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structure Diversification of Vancomycin through Peptide-Catalyzed, Site-Selective Lipidation: A Catalysis-Based Approach To Combat Glycopeptide-Resistant Pathogens

(2015) Sabesan Yoganathan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli

(2015) Phoom Chairatana et al.   Chemical Science

Aryl-alkyl-lysines: Membrane-Active Small Molecules Active against Murine Model of Burn Infection

(2015) Chandradhish Ghosh et al.   ACS Infectious Diseases

Glycopeptide Antibiotic To Overcome the Intrinsic Resistance of Gram-Negative Bacteria

(2015) Venkateswarlu Yarlagadda et al.   ACS Infectious Diseases

Lysine-Based Small Molecules That Disrupt Biofilms and Kill both Actively Growing Planktonic and Nondividing Stationary Phase Bacteria

(2015) Mohini M. Konai et al.   ACS Infectious Diseases

Tackling vancomycin-resistant bacteria with ‘lipophilic–vancomycin–carbohydrate conjugates’

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF ANTIBIOTICS

Glycopeptide antibiotics: Back to the future

(2014) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

(2014) Mohini M. Konai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Active Vancomycin Analogues: A Strategy to Combat Bacterial Resistance

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

(2014) Chandradhish Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

(2014) Peter I. O’Daniel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern

(2014) Runhui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

(2014) M. Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

(2013) Divakara S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Increased Cell Wall Teichoic Acid Production and D-alanylation Are Common Phenotypes among Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) Clinical Isolates

(2013) Ute Bertsche et al.   PLoS One

Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

(2013) J. R. Morones-Ramirez et al.   Science Translational Medicine

Redesign of Glycopeptide Antibiotics: Back to the Future

(2012) Robert C. James et al.   ACS Chemical Biology

Cephalosporin-3′-diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms

(2012) Nicolas Barraud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anion recognition and sensing with Zn(ii)–dipicolylamine complexes

(2012) Huy Tien Ngo et al.   CHEMICAL SOCIETY REVIEWS

The emerging problem of linezolid-resistant Staphylococcus

(2012) B. Gu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development

(2012) Haifan Wu et al.   Chemical Science

Recent advances in the synthesis of new glycopeptide antibiotics

(2011) Polly-Anna Ashford et al.   CHEMICAL SOCIETY REVIEWS

A Redesigned Vancomycin Engineered for Duald-Ala-d-Ala andd-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

A Molecular Mechanism for Bacterial Susceptibility to Zinc

(2011) Christopher A. McDevitt et al.   PLoS Pathogens

Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bacteria

(2010) Yuki Nakama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization

(2009) Oscar Domenech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis

(2008) Gemma L. Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid II: A central component in bacterial cell wall synthesis and a target for antibiotics

(2008) Ben de Kruijff et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The Bacteria Fight Back

(2008) G. Taubes   SCIENCE

The bacterial envelope as a target for novel anti-MRSA antibiotics

(2008) Françoise Van Bambeke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES