Neutrophils as Drivers of Immune Dysregulation in Autoimmune Diseases with Skin Manifestations

Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation

(2021) Sladjana Skopelja-Gardner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Neutrophils in Systemic Vasculitides

(2021) Despina Michailidou et al.   Frontiers in Immunology

Bite of the wolf: innate immune responses propagate autoimmunity in lupus

(2021) Sarthak Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Avacopan for the Treatment of ANCA-Associated Vasculitis

(2021) David R.W. Jayne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

(2020) Rishi R. Goel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

(2020) Franziska Herster et al.   Nature Communications

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs

(2020) Charlotte Owen-Woods et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease

(2020) Marta Vergnano et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases

(2020) Stefan Haskamp et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Immunity to commensal skin fungi promotes psoriasiform skin inflammation

(2020) Charlotte Hurabielle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions

(2020) Xinyu Zhou et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis

(2020) Carmelo Carmona-Rivera et al.   JCI Insight

Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus

(2020) Kathleen R Bashant et al.   ANNALS OF THE RHEUMATIC DISEASES

Cutaneous and systemic connections in lupus

(2020) Mitra P. Maz et al.   CURRENT OPINION IN RHEUMATOLOGY

Immunometabolism in the pathogenesis of systemic lupus erythematosus

(2020) Jorge Romo-Tena et al.   CURRENT OPINION IN RHEUMATOLOGY

The role of Th17 cells in psoriasis

(2020) Binbin Li et al.   IMMUNOLOGIC RESEARCH

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

(2020) Gantsetseg Tumurkhuu et al.   Frontiers in Immunology

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

(2020) Johann E. Gudjonsson et al.   JCI Insight

Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice

(2020) Soichiro Watanabe et al.   Scientific Reports

A Neutrophil-Driven Inflammatory Signature Characterizes the Blood Transcriptome Fingerprint of Psoriasis

(2020) Arun Rawat et al.   Frontiers in Immunology

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

(2019) Jing Guo et al.   Drug Design Development and Therapy

Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes

(2019) Sonja Moos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes

(2019) Shuai Shao et al.   FASEB JOURNAL

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

(2019) Alan Menter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Glucocorticoid-free induction regimen in severe ANCA-associated vasculitis using a combination of rituximab and eculizumab

(2019) David Ribes et al.   RHEUMATOLOGY

Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease

(2019) Alexandre Le Joncour et al.   ANNALS OF THE RHEUMATIC DISEASES

The Healing Power of Neutrophils

(2019) Mia Phillipson et al.   TRENDS IN IMMUNOLOGY

Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

(2019) Shuai Shao et al.   Frontiers in Immunology

Investigating the presence of neutrophil extracellular traps in cutaneous lesions of different subtypes of lupus erythematosus

(2019) Rémi Safi et al.   EXPERIMENTAL DERMATOLOGY

Oxidative stress involvement in psoriasis: a systematic review

(2019) Serafinella Patrizia Cannavò et al.   FREE RADICAL RESEARCH

Interleukin-36 promotes systemic Type-I IFN responses in severe forms of psoriasis

(2019) Marika Catapano et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa

(2019) Angel S. Byrd et al.   Science Translational Medicine

Neutrophil Extracellular Traps in Tissue and Periphery in Juvenile Dermatomyositis

(2019) Bhargavi Duvvuri et al.   Arthritis & Rheumatology

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils in Psoriasis

(2019) Chih-Chao Chiang et al.   Frontiers in Immunology

Blue and Long-Wave Ultraviolet Light Induce in vitro Neutrophil Extracellular Trap (NET) Formation

(2019) Elsa Neubert et al.   Frontiers in Immunology

Complement alternative pathway in ANCA-associated vasculitis: Two decades from bench to bedside

(2019) Benoit Brilland et al.   AUTOIMMUNITY REVIEWS

PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

(2019) Xue Han et al.   Science Translational Medicine

Neutrophil chemotaxis

(2018) Björn Petri et al.   CELL AND TISSUE RESEARCH

Cytokine production by human neutrophils: Revisiting the “dark side of the moon”

(2018) Nicola Tamassia et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Development of psoriasis by continual neutrophil infiltration into the epidermis

(2018) Hiroshi Katayama   EXPERIMENTAL DERMATOLOGY

The role of neutrophils in skin damage induced by tissue-deposited lupus IgG

(2018) Xuanxuan Guo et al.   IMMUNOLOGY

Clinical and immunological effects of adsorptive myeloid lineage leukocyte apheresis in patients with immune disorders

(2018) Takuro Kanekura   JOURNAL OF DERMATOLOGY

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor-Mediated Upregulation of CXCL16 in Psoriasis Orchestrates Neutrophil Activation

(2018) Sabine Steffen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study

(2018) You-Jung Ha et al.   PLoS One

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

(2018) Rui Lai et al.   REDOX REPORT

Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

(2018) Pragnesh Mistry et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil Elastase Inhibitors and Chronic Kidney Disease

(2018) Elsa Bronze-da-Rocha et al.   International Journal of Biological Sciences

Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in BEHÇET’S disease

(2018) Rémi Safi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Classification and management of adult inflammatory myopathies

(2018) Albert Selva-O'Callaghan et al.   LANCET NEUROLOGY

Anti-LL37 Antibodies Are Present in Psoriatic Arthritis (PsA) Patients: New Biomarkers in PsA

(2018) Loredana Frasca et al.   Frontiers in Immunology

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

(2018) Eleni Frangou et al.   ANNALS OF THE RHEUMATIC DISEASES

Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis

(2018) Panagiotis Paliogiannis et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Neutrophils instruct homeostatic and pathological states in naive tissues

(2018) Maria Casanova-Acebes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype

(2018) Sylviane Lambert et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis

(2017) Xin Lu et al.   JOURNAL OF AUTOIMMUNITY

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

(2017) Ming-Chin Lee et al.   JOURNAL OF IMMUNOLOGY

Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus

(2017) Benedikt Scholtissek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases

(2017) Tullia de Risi-Pugliese et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Effect of sivelestat sodium in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of randomized controlled trials

(2017) Shenglan Pu et al.   BMC Pulmonary Medicine

Granulocytes: New Members of the Antigen-Presenting Cell Family

(2017) Ang Lin et al.   Frontiers in Immunology

Reactive Oxygen Species and Neutrophil Function

(2016) Christine C. Winterbourn et al.   Annual Review of Biochemistry

The Alarmin Properties of DNA and DNA-associated Nuclear Proteins

(2016) Melinda Magna et al.   CLINICAL THERAPEUTICS

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

(2016) Ian K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis

(2016) Nursel Dilek et al.   Postepy Dermatologii i Alergologii

Neutrophil extracellular trap formation is increased in psoriasis and induces human β-defensin-2 production in epidermal keratinocytes

(2016) Stephen Chu-Sung Hu et al.   Scientific Reports

Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa

(2015) A.L. Lima et al.   BRITISH JOURNAL OF DERMATOLOGY

A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis

(2015) Anthony De Soyza et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil plasticity: acquisition of phenotype and functionality of antigen-presenting cell

(2015) A. Takashima et al.   JOURNAL OF LEUKOCYTE BIOLOGY

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

(2015) Peter C. Grayson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

(2014) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis

(2014) H. Sumida et al.   JOURNAL OF IMMUNOLOGY

Vesicular LL-37 Contributes to Inflammation of the Lesional Skin of Palmoplantar Pustulosis

(2014) Masamoto Murakami et al.   PLoS One

Inhibition of HumanγδT Cell Proliferation and Effector Functions by Neutrophil Serine Proteases

(2014) J. Fazio et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Psoriatic keratinocytes prime neutrophils for an overproduction of superoxide anions

(2013) Simon Guérard et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Brief Report: Attention Deficit and Hyperactivity Disorder Scores Are Elevated and Respond toN-Acetylcysteine Treatment in Patients With Systemic Lupus Erythematosus

(2013) Ricardo J. Garcia et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes

(2012) Stacy J. Park et al.   INFECTION AND IMMUNITY

Secretory Leukocyte Proteinase Inhibitor-Competent DNA Deposits Are Potent Stimulators of Plasmacytoid Dendritic Cells: Implication for Psoriasis

(2012) J. Skrzeczynska-Moncznik et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Neutrophil elastase treated dendritic cells promote the generation of CD4+FOXP3+ regulatory T cells in vitro

(2011) N.L. Tateosian et al.   CELLULAR IMMUNOLOGY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus

(2011) Alexander Kreuter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa

(2011) Christoph Schlapbach et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Granulocytapheresis in the Treatment of Patients with Rheumatoid Arthritis

(2010) Morihiro Ohara et al.   ARTIFICIAL ORGANS

A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement

(2010) M. A. Lindorfer et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE