PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer

(2019) Jorge Blando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus

(2019) Richard Furie et al.   JOURNAL OF CLINICAL INVESTIGATION

The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation

(2018) Wenwen Xu et al.   Cellular & Molecular Immunology

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation

(2018) Purvi Mande et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of neutrophil extracellular traps in rheumatic diseases

(2018) Falko Apel et al.   Nature Reviews Rheumatology

Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type I Interferon Loop

(2017) Jasmine N. Stannard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice

(2017) PA Sergent et al.   LUPUS

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

(2017) Jianjun Gao et al.   NATURE MEDICINE

Gene expression profiling comes closer to the clinic

(2017) Guillermo Barturen et al.   Nature Reviews Rheumatology

Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability

(2017) Qi Wang et al.   Scientific Reports

VISTA Deficiency Accelerates the Development of Fatal Murine Lupus Nephritis

(2017) Sabrina Ceeraz et al.   Arthritis & Rheumatology

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Cutaneous lupus erythematosus

(2016) Jasmine N. Stannard et al.   CURRENT OPINION IN RHEUMATOLOGY

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

(2016) Jong Hoon Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Cellular and metabolic requirements of effector T cells

(2016) George C. Tsokos   Nature Reviews Rheumatology

Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?

(2016) Michiel van der Vlist et al.   Nature Reviews Rheumatology

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

Modelling clinical systemic lupus erythematosus: similarities, differences and success stories

(2016) Teja Celhar et al.   RHEUMATOLOGY

Systemic lupus erythematosus

(2016) Arvind Kaul et al.   Nature Reviews Disease Primers

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

(2015) Clément Jacquemin et al.   IMMUNITY

Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus

(2015) Lino L. Teichmann et al.   IMMUNITY

Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus

(2015) William E. O'Gorman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanistic Assessment of PD-1H Coinhibitory Receptor–Induced T Cell Tolerance to Allogeneic Antigens

(2015) Dallas B. Flies et al.   JOURNAL OF IMMUNOLOGY

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses

(2015) Jun Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53

(2015) K. W. Yoon et al.   SCIENCE

Pathophysiology of cutaneous lupus erythematosus

(2015) Jordan C Achtman et al.   ARTHRITIS RESEARCH & THERAPY

VISTA Regulates the Development of Protective Antitumor Immunity

(2014) I. Le Mercier et al.   CANCER RESEARCH

Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity

(2014) Dallas B. Flies et al.   JOURNAL OF CLINICAL INVESTIGATION

PILRα Negatively Regulates Mouse Inflammatory Arthritis

(2014) Yonglian Sun et al.   JOURNAL OF IMMUNOLOGY

Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity

(2014) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

(2014) Ryan B. Thorpe et al.   TheScientificWorldJOURNAL

Mutation of POLB Causes Lupus in Mice

(2014) Alireza G. Senejani et al.   Cell Reports

Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene

(2014) Qingqing Jiao et al.   International Journal of Genomics

Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation

(2013) H Leiss et al.   LUPUS

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

(2011) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models

(2011) D. B. Flies et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus

(2011) Yong Xie et al.   BioScience Trends

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

(2009) Pui Y. Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus

(2009) George K. Bertsias et al.   ARTHRITIS AND RHEUMATISM

Murine models of cutaneous involvement in lupus erythematosus

(2009) Mehran Ghoreishi et al.   AUTOIMMUNITY REVIEWS

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons

(2009) Westley H. Reeves et al.   TRENDS IN IMMUNOLOGY

Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression

(2008) Ou Jin et al.   LUPUS

Plasmacytoid dendritic cells are present in cutaneous dermatomyositis lesions in a pattern distinct from lupus erythematosus

(2007) Jennifer M. McNiff et al.   JOURNAL OF CUTANEOUS PATHOLOGY