TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

(2020) Jeong-Ryul Hwang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling

(2020) Shen Yang et al.   Science Signaling

Regulation of T Helper Cell Fate by TCR Signal Strength

(2020) Nayan D. Bhattacharyya et al.   Frontiers in Immunology

The membrane proximal proline-rich region and correct order of C-terminal tyrosines on the adaptor protein LAT are required for TCR-mediated signaling and downstream functions

(2020) Mikaela M. Tremblay et al.   CELLULAR SIGNALLING

TRAF family molecules in T cells: Multiple receptors and functions

(2019) Tina Arkee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential T-cell receptor signals for T helper cell programming

(2018) Penelope A. Morel   IMMUNOLOGY

TRAF3 regulation of inhibitory signaling pathways in B and T lymphocytes by kinase and phosphatase localization

(2018) Alicia M. Wallis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

(2018) Lakshmi Balagopalan et al.   Nature Communications

Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways

(2018) Jian-Hong Shi et al.   Frontiers in Immunology

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer

(2017) Darren J. Wozniak et al.   Nature Communications

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

(2017) Alicia M. Wallis et al.   Scientific Reports

TRAF3 as a powerful and multitalented regulator of lymphocyte functions

(2016) Gail A. Bishop   JOURNAL OF LEUKOCYTE BIOLOGY

Nuclear TRAF3 is a negative regulator of CREB in B cells

(2016) Nurbek Mambetsariev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

(2016) Dominique Davidson et al.   Cell Reports

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

(2015) Gaofeng Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

(2015) Omar I. Vivar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of 4-anilino α-carbolines as novel Brk inhibitors

(2014) Kazem Ahmed Mahmoud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2

(2014) Zuoan Yi et al.   NATURE IMMUNOLOGY

BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration

(2014) Sayem Miah et al.   PLoS One

TRAF3 Regulates Homeostasis of CD8+ Central Memory T Cells

(2014) Zuoan Yi et al.   PLoS One

Protein-tyrosine Phosphatase 1B Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and Kinase BRK/PTK6 in Ovarian Cancer Cells

(2013) Gaofeng Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells

(2013) Zuoan Yi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

(2012) Rebekah R. Bartelt et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

(2011) Joanne M. Hildebrand et al.   IMMUNOLOGICAL REVIEWS

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

An Enigmatic Tail of CD28 Signaling

(2010) J. S. Boomer et al.   Cold Spring Harbor Perspectives in Biology

Regulation of lymphocyte development and activation by the LAT family of adapter proteins

(2009) Deirdre M. Fuller et al.   IMMUNOLOGICAL REVIEWS

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

(2009) L. F. Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY