Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection

(2014) Z. J. Kraus et al.   JOURNAL OF IMMUNOLOGY

IL-17A Inhibits the Expansion of IL-17A-Producing T Cells in Mice through "Short-Loop" Inhibition via IL-17 Receptor

(2014) E. Smith et al.   JOURNAL OF IMMUNOLOGY

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

(2011) S. Gardam et al.   BLOOD

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

(2011) Suzanne Paz et al.   CELL RESEARCH

Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1)

(2011) Kelly M. Arcipowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling

(2011) T. So et al.   JOURNAL OF IMMUNOLOGY

Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes

(2011) Ping Xie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antigen-independent signalosome of CARMA1, PKC , and TNF receptor-associated factor 2 (TRAF2) determines NF- B signaling in T cells

(2011) T. So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF5 Deficiency Accelerates Atherogenesis in Mice by Increasing Inflammatory Cell Recruitment and Foam Cell Formation

(2010) Anna Missiou et al.   CIRCULATION RESEARCH

BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-κB activation

(2010) Osamu Ikeda et al.   FEBS LETTERS

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

(2010) Rebeca Pérez de Diego et al.   IMMUNITY

Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1

(2010) John P. Graham et al.   IMMUNOLOGICAL REVIEWS

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

(2010) Ai-Ping Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

(2010) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

(2010) Hideki Sanjo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

(2010) Pradeep Bista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling

(2010) Jian Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

(2010) Shu Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling

(2010) Joanne M. Hildebrand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production

(2010) Jose M. González-Navajas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential TRAF3 Utilization by a Variant Human CD40 Receptor with Enhanced Signaling

(2010) A. L. Peters et al.   JOURNAL OF IMMUNOLOGY

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

(2010) Miwa Sasai et al.   MOLECULAR IMMUNOLOGY

TRAF5 Is a Downstream Target of MAVS in Antiviral Innate Immune Signaling

(2010) Eric D. Tang et al.   PLoS One

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

(2010) Jamel Mankouri et al.   PLoS Pathogens

Identification of Copy Number Abnormalities and Inactivating Mutations in Two Negative Regulators of Nuclear Factor- B Signaling Pathways in Waldenstrom's Macroglobulinemia

(2009) E. Braggio et al.   CANCER RESEARCH

The contribution of direct TLR signaling to T cell responses

(2009) Adeeb H. Rahman et al.   IMMUNOLOGIC RESEARCH

Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6

(2009) Shu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tyrosine Kinase c-Src Enhances RIG-I (Retinoic Acid-inducible Gene I)-elicited Antiviral Signaling

(2009) Ingvild B. Johnsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets

(2009) Michael W. Tusche et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Roles of the TRAF2/3 Binding Site in Differential B Cell Signaling by CD40 and Its Viral Oncogenic Mimic, LMP1

(2009) J. P. Graham et al.   JOURNAL OF IMMUNOLOGY

Antigen Receptor Signals Rescue B Cells from TLR Tolerance

(2009) J. S. Poovassery et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Importance of IL-6 and Cooperation between Innate and Adaptive Immune Receptors in Cellular Vaccination with B Lymphocytes

(2009) T. J. Vanden Bush et al.   JOURNAL OF IMMUNOLOGY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40

(2009) Z. J. Kraus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional roles for T cell CD40 in infection and autoimmune disease: The role of CD40 in lymphocyte homeostasis

(2009) Melissa E. Munroe   SEMINARS IN IMMUNOLOGY

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

A novel polymorphism of the human CD40 receptor with enhanced function

(2008) A. L. Peters et al.   BLOOD

Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer

(2008) Juan M. Zapata et al.   BLOOD

TLR7 and CD40 cooperate in IL-6 productionviaenhanced JNK and AP-1 activation

(2008) Tony J. Vanden Bush et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome

(2008) Tal Birnberg et al.   IMMUNITY

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

CD40 on NOD CD4 T cells contributes to their activation and pathogenicity

(2008) Rocky L. Baker et al.   JOURNAL OF AUTOIMMUNITY

FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway

(2008) Takahito Sanada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

(2008) Y. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex

(2008) A. Matsuzawa et al.   SCIENCE