BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration

PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

(2013) Shin-Ae Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1

(2013) Raghuveera K. Goel et al.   FEBS Journal

Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

(2012) Yiwei Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1

(2012) M. Siouda et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo

(2012) S Miah et al.   Oncogenesis

Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)

(2011) Karen Balassiano et al.   CANCER LETTERS

Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers

(2011) Amandine Saulnier et al.   INTERNATIONAL JOURNAL OF CANCER

Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts

(2011) Aya Kawamata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oncogenic Tyrosine Kinases Target Dok-1 for Ubiquitin-Mediated Proteasomal Degradation To Promote Cell Transformation

(2011) J. A. Janas et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer

(2011) Pierre-Luc Mercier et al.   Molecular Oncology

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell

(2011) Wei Yu et al.   PLoS One

Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells

(2010) Patrick M. Brauer et al.   CELL CYCLE

PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1

(2010) Shin-Ae Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells

(2010) Osamu Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake

(2010) Marie-Pierre Lambert et al.   JOURNAL OF HEPATOLOGY

Comparative Analysis of Human Src-Family Kinase Substrate Specificity in Vitro

(2010) Hiroyuki Takeda et al.   JOURNAL OF PROTEOME RESEARCH

Mice lacking Dok-1, Dok-2 and Dok-3 succumb to aggressive histiocytic sarcoma

(2010) Ryuichi Mashima et al.   LABORATORY INVESTIGATION

Identification of DOK genes as lung tumor suppressors

(2010) Alice H Berger et al.   NATURE GENETICS

Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage

(2009) Amanda J. Harvey et al.   AMERICAN JOURNAL OF PATHOLOGY

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

(2009) Osamu Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice

(2009) C. Peng et al.   BLOOD

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

(2009) Kiven E. Lukong et al.   CELLULAR SIGNALLING

The roles of Dok family adapters in immunoreceptor signaling

(2009) Ryuichi Mashima et al.   IMMUNOLOGICAL REVIEWS

Oncogenic Functions of PTK6 are Enhanced by Its Targeting to Plasma Membrane But Abolished by Its Targeting to Nucleus

(2009) H. Ie Kim et al.   JOURNAL OF BIOCHEMISTRY

Breast Tumor Kinase Phosphorylates p190RhoGAP to Regulate Rho and Ras and Promote Breast Carcinoma Growth, Migration, and Invasion

(2008) C.-H. Shen et al.   CANCER RESEARCH

Mechanisms of ErbB receptor negative regulation and relevance in cancer

(2008) William H.D. Fry et al.   EXPERIMENTAL CELL RESEARCH

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

(2008) B. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

(2007) Kiven E. Lukong et al.   CELLULAR SIGNALLING