Genetically engineered exosomes display RVG peptide and selectively enrich a neprilysin variant: a potential formulation for the treatment of Alzheimer’s disease

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

(2021) Rebekah Omarkhail Elliott et al.   Pharmaceutics

Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice

(2020) Niansheng Lai et al.   Journal of Neuroinflammation

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

(2020) Dae Hyun Ha et al.   Cells

Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer’s Disease

(2020) Yavar Jahangard et al.   Frontiers in Neuroscience

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

(2020) Rodrigo Pinheiro Araldi et al.   Cells

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

(2019) Guo-hong Cui et al.   Immunity & Ageing

The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases

(2019) Armita Mahdavi Gorabi et al.   MOLECULAR NEUROBIOLOGY

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

(2019) María Izco et al.   MOLECULAR THERAPY

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

The exosome of adipose-derived stem cells reduces β-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer’s disease

(2018) Mijung Lee et al.   BRAIN RESEARCH

Serum exosomes contain ECRG4 mRNA that suppresses tumor growth via inhibition of genes involved in inflammation, cell proliferation, and angiogenesis

(2018) Liang Mao et al.   CANCER GENE THERAPY

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Tumor-derived exosomes induce CD8+ T cell suppressors

(2017) Brian T. Maybruck et al.   Journal for ImmunoTherapy of Cancer

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

(2016) Dang Xitong et al.   GENE

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeted delivery of nano-PTX to the brain tumor-associated macrophages

(2016) Lei Zou et al.   Oncotarget

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes and exosomal miRNAs in cardiovascular protection and repair

(2015) Costanza Emanueli et al.   VASCULAR PHARMACOLOGY

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

(2014) Carl I. Webster et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

(2013) Matthew J. Haney et al.   PLoS One

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Mesenchymal stem cells in tumor development

(2012) Benjamin G. Cuiffo et al.   Cell Adhesion & Migration

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Adipose-derived stem cells: Isolation, expansion and differentiation☆

(2008) B BUNNELL et al.   METHODS

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC