Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

β-Amyloid and Neprilysin Computational Studies Identify Critical Residues Implicated in Binding Specificity

(2014) Darrick Pope et al.   Journal of Chemical Information and Modeling

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Enhanced Proteolytic Clearance of Plasma A  by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A  in Mice

(2013) J. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

(2013) Lauren A. McCord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Site Mutations Change the Cleavage Specificity of Neprilysin

(2012) Travis Sexton et al.   PLoS One

Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

(2011) Melanie S. Glossop et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

A nonhuman primate model of Alzheimer’s disease generated by intracranial injection of amyloid-beta42 and thiorphan

(2010) Wende Li et al.   METABOLIC BRAIN DISEASE

New Function for an Old Enzyme: NEP Deficient Mice Develop Late-Onset Obesity

(2010) Matthias Becker et al.   PLoS One

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alteration of substrate specificity of rat neurolysin from matrix metalloproteinase-2/9-type to -3-type specificity by comprehensive mutation

(2008) T. Kadonosono et al.   PROTEIN ENGINEERING DESIGN & SELECTION