Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

(2020) Tommi P. Kilpeläinen et al.   BIOMEDICINE & PHARMACOTHERAPY

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

(2019) Panagiota Mavroeidi et al.   ACTA NEUROPATHOLOGICA

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

(2019) Jianqun Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors

(2019) Tommi P. Kilpeläinen et al.   ACS Medicinal Chemistry Letters

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

(2019) Reinis Svarcbahs et al.   PHARMACOLOGICAL RESEARCH

Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target

(2018) Teemu A. Natunen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The Molecular Mechanism of Alpha-Synuclein Dependent Regulation of Protein Phosphatase 2A Activity

(2018) Jing Qu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Therapeutic targeting of PP2A

(2018) Caitlin M. O’Connor et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

(2018) Reinis Svarcbahs et al.   Scientific Reports

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

(2018) Raquel Pinho et al.   HUMAN MOLECULAR GENETICS

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

(2018) Antonio Heras-Garvin et al.   MOVEMENT DISORDERS

Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy

(2018) Giacomo Monzio Compagnoni et al.   Stem Cell Reports

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture

(2017) Timo T. Myöhänen et al.   NEUROSCIENCE LETTERS

Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3)

(2016) Nobuyuki Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain

(2016) Reinis Svarcbahs et al.   JOURNAL OF NEUROSCIENCE

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

(2016) Abid Oueslati   Journal of Parkinsons Disease

Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies

(2016) Hye-Jin Park et al.   Annals of Clinical and Translational Neurology

Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1

(2016) Akter MST Yeasmin et al.   PLoS One

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

(2015) Mari H. Savolainen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System

(2015) Eduardo R. Zimmer et al.   MOLECULAR NEUROBIOLOGY

Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy

(2015) Katharina Pukaß et al.   Frontiers in Cellular Neuroscience

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

(2014) Yasmine T. Asi et al.   GLIA

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

(2014) Mari H. Savolainen et al.   NEUROBIOLOGY OF DISEASE

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

(2014) B I Pérez-Revuelta et al.   Cell Death & Disease

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases

(2013) M.J. Hannula et al.   NEUROSCIENCE

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

(2012) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes

(2012) Lisa Schwarz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo

(2012) J. Wu et al.   NEUROSCIENCE

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells

(2009) Christine L. Kragh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY