Dynein light intermediate chains as pivotal determinants of dynein multifunctionality

Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation

(2020) Amit Sharma et al.   JOURNAL OF CELL SCIENCE

Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions

(2020) Cristina Renna et al.   STRUCTURE

Coiled‐coil registry shifts in the F684I mutant of Bicaudal D result in cargo‐independent activation of dynein motility

(2020) Heying Cui et al.   TRAFFIC

DLIC1 , but not DLIC2 , is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells

(2019) Ipek Even et al.   FEBS Journal

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis

(2019) Devashish Dwivedi et al.   JOURNAL OF CELL BIOLOGY

Distinct roles for dynein light intermediate chains in neurogenesis, migration, and terminal somal translocation

(2019) João Carlos Gonçalves et al.   JOURNAL OF CELL BIOLOGY

CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic

(2019) Yuxiao Wang et al.   JOURNAL OF CELL BIOLOGY

LRRK1 phosphorylation of Rab7 at Ser-72 links trafficking of EGFR-containing endosomes to its effector RILP

(2019) Hiroshi Hanafusa et al.   JOURNAL OF CELL SCIENCE

Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding

(2019) Crystal R. Noell et al.   Journal of Physical Chemistry Letters

Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

(2019) Mohamed M. Elshenawy et al.   Nature Chemical Biology

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

(2018) Thomas E Sladewski et al.   eLife

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

(2018) Mark A McClintock et al.   eLife

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes

(2018) Julie K. Monda et al.   Open Biology

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Structure of the RZZ complex and molecular basis of its interaction with Spindly

(2017) Shyamal Mosalaganti et al.   JOURNAL OF CELL BIOLOGY

Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay between Phosphorylation Site and Disordered Spliced Linkers

(2017) Jing Jie et al.   STRUCTURE

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint

(2016) Sagar P. Mahale et al.   PLoS One

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation

(2016) Sagar Mahale et al.   Scientific Reports

Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms

(2015) K. Kevin Pfister   EXPERIMENTAL CELL RESEARCH

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells

(2015) Kaowen Yan et al.   JOURNAL OF CELL BIOLOGY

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores

(2015) Devinderjit K. Moudgil et al.   JOURNAL OF CELL BIOLOGY

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

(2015) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility

(2015) Feng J. Gao et al.   TRAFFIC

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion

(2014) Laura A. Jones et al.   JOURNAL OF CELL BIOLOGY

PKA-dependent dynein switching from lysosomes to adenovirus: A novel form of host–virus competition

(2014) Julian Scherer et al.   JOURNAL OF CELL BIOLOGY

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

(2014) Max A. Schlager et al.   Cell Reports

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

(2013) Sachin Kotak et al.   EMBO JOURNAL

Systematic dissection of dynein regulators in mitosis

(2013) Jonne A. Raaijmakers et al.   JOURNAL OF CELL BIOLOGY

Microtubule motors mediate endosomal sorting by maintaining functional domain organization

(2013) S. D. Hunt et al.   JOURNAL OF CELL SCIENCE

Native disorder mediates binding of dynein to NudE and dynactin

(2012) Elisar Barbar   BIOCHEMICAL SOCIETY TRANSACTIONS

Intrinsic Disorder in Dynein Intermediate Chain Modulates Its Interactions with NudE and Dynactin

(2012) Afua Nyarko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trk Activation of the ERK1/2 Kinase Pathway Stimulates Intermediate Chain Phosphorylation and Recruits Cytoplasmic Dynein to Signaling Endosomes for Retrograde Axonal Transport

(2012) D. J. Mitchell et al.   JOURNAL OF NEUROSCIENCE

Multiple modes of cytoplasmic dynein regulation

(2012) Richard B. Vallee et al.   NATURE CELL BIOLOGY

Polo-like Kinase1 Is Required for Recruitment of Dynein to Kinetochores during Mitosis

(2011) Jason R. Bader et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutually Exclusive Cytoplasmic Dynein Regulation by NudE-Lis1 and Dynactin

(2011) Richard J. McKenney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex

(2010) Conor P. Horgan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

(2010) Max A Schlager et al.   EMBO JOURNAL

The Crystal Structure of Dynein Intermediate Chain-Light Chain Roadblock Complex Gives New Insights into Dynein Assembly

(2010) Justin Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of dynein to late endosomes and lysosomes through light intermediate chains

(2010) Serena C. Tan et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration

(2009) Jan Schmoranzer et al.   CURRENT BIOLOGY

Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint

(2009) Mylavarapu V S Sivaram et al.   EMBO JOURNAL

Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment

(2009) C. P. Horgan et al.   JOURNAL OF CELL SCIENCE

Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

(2009) Krysten J. Palmer et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

(2008) Jacqueline Whyte et al.   JOURNAL OF CELL BIOLOGY

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA