MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis

A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients

(2021) Gabriella Dobrowolny et al.   Cell Death Discovery

MicroRNAs and HDAC4 protein expression in the skeletal muscle of ALS patients

(2020) Valentina Pegoraro et al.   CLINICAL NEUROPATHOLOGY

Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis

(2020) Metka Ravnik-Glavač et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

(2020) Myung Geun Kook et al.   Scientific Reports

miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro

(2020) Roza K. Przanowska et al.   FASEB JOURNAL

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice

(2020) Guillem Mòdol-Caballero et al.   NEUROBIOLOGY OF DISEASE

Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression

(2020) Agnes Badu-Mensah et al.   Scientific Reports

Molecular and Cellular Mechanisms Affected in ALS

(2020) Laura Le Gall et al.   Journal of Personalized Medicine

Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome

(2020) Lee J. Martin et al.   Frontiers in Neurology

Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation

(2019) Tristan J. M. Gonçalves et al.   Scientific Reports

Wnt/β‐catenin signaling induces the myomiRs miR‐133b and miR‐206 to suppress Pax7 and induce the myogenic differentiation program

(2019) Shuang Cui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates

(2019) Stefania Marcuzzo et al.   NEUROSCIENCE

Motor Neuron Susceptibility in ALS/FTD

(2019) Audrey M. G. Ragagnin et al.   Frontiers in Neuroscience

The role of skeletal muscle in amyotrophic lateral sclerosis: a ‘dying‐back’ or ‘dying‐forward’ phenomenon?

(2019) Stavroula Tsitkanou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer

(2018) Hongyu Liu et al.   Molecular Cancer

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals

(2018) David Jee et al.   MOLECULAR CELL

Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis

(2018) Radhika Raheja et al.   MUSCLE & NERVE

Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis

(2018) Ying Si et al.   NEUROBIOLOGY OF DISEASE

hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway

(2018) Malgorzata Halon-Golabek et al.   Journal of Cachexia Sarcopenia and Muscle

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

(2018) Matthew D. Cykowski et al.   Acta Neuropathologica Communications

Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

(2018) Maria Liguori et al.   Frontiers in Molecular Neuroscience

Exercise and the control of muscle mass in human

(2018) Marc Francaux et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients

(2018) Daniel Saucier et al.   BRAIN RESEARCH

Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis

(2017) Valentina Cappello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Micro-RNAs in ALS muscle: Differences in gender, age at onset and disease duration

(2017) Valentina Pegoraro et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

What is “Hyper” in the ALS Hypermetabolism?

(2017) Alberto Ferri et al.   MEDIATORS OF INFLAMMATION

Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)

(2017) Rachel Waller et al.   NEUROBIOLOGY OF AGING

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Potential therapeutic targets for ALS: MIR206, MIR208b and MIR499 are modulated during disease progression in the skeletal muscle of patients

(2017) Lorena Di Pietro et al.   Scientific Reports

Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis

(2017) Alessandra Gaiani et al.   JAMA Neurology

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries

(2016) Ryan M. Seals et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Circulating microRNAs as biomarkers of muscle differentiation and atrophy in ALS

(2016) Elisabetta Tasca et al.   CLINICAL NEUROPATHOLOGY

Muscle-specific microRNAs in skeletal muscle development

(2016) Martin Horak et al.   DEVELOPMENTAL BIOLOGY

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Impaired exercise tolerance, mitochondrial biogenesis, and muscle fiber maintenance in miR-133a–deficient mice

(2016) Yaohui Nie et al.   FASEB JOURNAL

Molecular networks in skeletal muscle plasticity

(2016) Hans Hoppeler   JOURNAL OF EXPERIMENTAL BIOLOGY

Length-dependent axo-terminal degeneration at the neuromuscular synapses of type II muscle in SOD1 mice

(2016) C. Tallon et al.   NEUROSCIENCE

Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis

(2016) L. Jensen et al.   Biomed Research International

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling

(2016) Qiang Kai Huang et al.   MEDICAL SCIENCE MONITOR

Integrated ordination of miRNA and mRNA expression profiles

(2015) Giacomo Diaz et al.   BMC GENOMICS

Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS

(2015) Parvathi Menon et al.   CLINICAL NEUROPHYSIOLOGY

Familial Amyotrophic Lateral Sclerosis

(2015) Kevin Boylan   NEUROLOGIC CLINICS

The Whereabouts of microRNA Actions: Cytoplasm and Beyond

(2015) Anthony K.L. Leung   TRENDS IN CELL BIOLOGY

Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

(2015) Stefania Marcuzzo et al.   Molecular Brain

Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis

(2015) Ikuko Takahashi et al.   Molecular Brain

MicroRNA-486–dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy–associated symptoms

(2014) Matthew S. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis

(2014) Janne M. Toivonen et al.   PLoS One

The Role of Muscle microRNAs in Repairing the Neuromuscular Junction

(2014) Gregorio Valdez et al.   PLoS One

Skeletal Muscle Satellite Cells in Amyotrophic Lateral Sclerosis

(2014) Annarita Scaramozza et al.   ULTRASTRUCTURAL PATHOLOGY

MicroRNA in skeletal muscle development, growth, atrophy, and disease

(2014) Anja Kovanda et al.   Wiley Interdisciplinary Reviews-RNA

NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study

(2014) Robert G. Miller et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

The miR-206/133b cluster is dispensable for development, survival and regeneration of skeletal muscle

(2014) Thomas Boettger et al.   Skeletal Muscle

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

(2013) Mariana C. Rocha et al.   PLoS One

A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation

(2013) Y Feng et al.   Cell Death & Disease

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

(2013) Amy Heidersbach et al.   eLife

Inhibition of Myogenic MicroRNAs 1, 133, and 206 by Inflammatory Cytokines Links Inflammation and Muscle Degeneration in Adult Inflammatory Myopathies

(2013) Robert W. Georgantas et al.   Arthritis & Rheumatology

Skeletal Muscle in Motor Neuron Diseases: Therapeutic Target and Delivery Route for Potential Treatments

(2012) Luc Dupuis et al.   CURRENT DRUG TARGETS

Notch3 and Mef2c Proteins Are Mutually Antagonistic via Mkp1 Protein and miR-1/206 MicroRNAs in Differentiating Myoblasts

(2012) Jeffrey Gagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice

(2012) Ning Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice

(2012) M. P. Heyer et al.   JOURNAL OF NEUROSCIENCE

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

(2012) Aaron P. Russell et al.   NEUROBIOLOGY OF DISEASE

Abnormalities of satellite cells function in amyotrophic lateral sclerosis

(2011) Pierre-François Pradat et al.   Amyotrophic Lateral Sclerosis

Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: A longitudinal MRI study

(2011) Stefania Marcuzzo et al.   EXPERIMENTAL NEUROLOGY

TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4

(2011) Catherine E. Winbanks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

(2011) Ning Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Insulin-Like Growth Factor-1 Receptor Is Regulated by microRNA-133 during Skeletal Myogenesis

(2011) Mian-Bo Huang et al.   PLoS One

MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis

(2011) K. Goljanek-Whysall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

(2010) Viviana Moresi et al.   CELL

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7

(2010) Jian-Fu Chen et al.   JOURNAL OF CELL BIOLOGY

miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7

(2010) B. K. Dey et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486

(2010) E. M. Small et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions

(2009) Leonardo Elia et al.   CIRCULATION

Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models

(2009) Luc Dupuis et al.   CURRENT OPINION IN PHARMACOLOGY

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

(2008) N. Liu et al.   GENES & DEVELOPMENT

An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology

(2008) S. Xiao et al.   JOURNAL OF NEUROSCIENCE

Preferential motor unit loss in the SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2008) J. Hegedus et al.   JOURNAL OF PHYSIOLOGY-LONDON